One-pot ruthenium catalyzed regioselective C-H functionalization of chromeno[4,3-c]pyrazol-4-ones and their photophysical studies Dinesh Singla, Kamaldeep Paul Thapar Institute of Engineering and Technology, India Fused π -conjugated scaffolds have broad applications in material sciences, natural products, and pharmaceuticals. 1 Hence, designing new compounds using different bioactive compounds and their late-stage modification is a fascinating topic for organic chemists. 2 Conjugates comprising coumarin and pyrazole belong to a family of structurally distinct heterocyclic compounds with significant biological properties. 3 Owing to their considerable importance, effective synthesis of these moieties and their selective functionalization have claimed ongoing attention from the organic community. 4 Herein, we show one-pot access to 1-phenyl-1 H -chromeno[4,3- c ]pyrazol-4-one and in situortho- C-H functionalization using olefins via ruthenium-catalyzed intermolecular dehydrogenative coupling reaction in the absence of base and silver additive. Later on, photophysical studies of final compounds are discussed. References 1. S. Sahoo and S. Pal, Rapid Access to Benzimidazo [1, 2- a ] quinoline-Fused Isoxazoles via Pd (II)-Catalyzed Intramolecular Cross Dehydrogenative Coupling: Synthetic Versatility and Photophysical Studies., J. Org. Chem., 2021, 86 , 4081. 2. L. Zhang and T. Ritter, A Perspective on Late-Stage Aromatic C–H Bond Functionalization, J. Am. Chem. Soc ., 2022, 144 , 2399. 3. J. Akhtar, A. A. Khan, Z. Ali, R. Haider and M. S. Yar, Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities., Eur. J. Med. Chm. 2017, 125 , 143. 4. D. Cao, Z. Liu, P. Verwilst, S. Koo, P. Jangjili, J. S. Kim and W. Lin, Coumarin-based small-molecule fluorescent chemosensors., Chem. Rev., 2019, 119 , 10403
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