Total synthesis of oligosaccharides derived from acinetobacter baumannii ATCC 17961 Qingju Zhang, Yongxin Hu, Liangshen Duan, Liming Wang Jiangxi Normal University, China A cinetobacter baumannii , which is a Gram-negative bacterium listed by The World Health Organization as a critical target in urgent need of new antimicrobials, is a common cause of soft tissue and urinary tract infections, septiceamia, pneumonia and meningitis. [1] Glycoconjugate vaccines are a general weapon to prevent infectious diseases. [2] Lipid polysaccharide (LPS) is a key target for bacteriophage and vaccine therapies currently being developed for treatment of infections caused by the extensively antibiotic resistant bacterial species. [3] The O-chain of A. baumannii ATCC 17961 LPS was determined to be a polymer of a highly branched pentasaccharide repeating unit composed of 2,3-diacetamido-2,3-dideoxy-D-glucuronic acid, 2-acetamido-2-deoxy-D-glucose, 2-acetamido-2-deoxy-D-galactose, D-glucose, and D-galactose. [4] Herein, we described the synthesis of oligosaccharides derived from A. baumannii ATCC 17961 for develop ing synthetic carbohydrate-based vaccine against A. baumannii infection.
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