Photoredox catalysis for the highly selective deuteration Nian Li, Chengjian Zhu, Jin Xie Nanjing University, China
Deuterated chemicals are becoming irreplaceable in pharmaceutical engineering, material science and synthetic chemistry. In 2021, our group reported a practical and precise deuteration of readily available complex carboxylic acids by synergistic photoredox and HAT catalysis. The use of a recirculation reactor with a peristaltic pump supports a scalable preparative ability (up to 50 mmol) under very mild reaction conditions. Then in 2022, we developed a highly selective H/D exchange protocol of remote unactivated C(sp3)-H bonds via the PCET/1,5-HAT process. A wide range of remote tertiary, secondary and primary C(sp3)-H bonds can be smoothly converted to the corresponding C-D bonds. This protocol can also achieve tunable multideuteration of substrates containing more than one remote C(sp3)-H sites, which represents an significant step-forward in 1,5-HAT-induced multi- functionaztion.
P133
© The Author(s), 2022
Made with FlippingBook Learn more on our blog