Biotechnology, 131 Princess Street, Manchester, M1 3DN, UK; e-mail: nicholas.turner@manchester.ac.uk
Discovery and engineering of new multi-functional biocatalysts for organic synthesis Nicholas J. Turner University of Manchester, UK This lecture will chart the discovery and synthetic application of three closely related types of oxidoreductase enzymes, namely imine reductases (IREDs), reductive aminases (RedAms) and ene-imine reductases (EneIREDs). These remarkable enzymes are able to catalyse synthetically useful transformations, across a broad range of substrates, including imine reduction, reductive amination and conjugate reduction. This lecture will discuss aspects of enzyme discovery, enzyme engineering and application to target molecule synthesis.[1-4] This lecture will chart the discovery and synthetic application of three closely related types of oxidoreductase enzymes, namely imine reductases (IREDs), reductive aminases (RedAms) and ene-imine reductases (EneIREDs). These remarkable enzymes are able to catalyse synthetically useful transformations, across a broad range of substrates, including imine reduction, reductive amination and conjugate reduction. This lecture will discuss aspects of enzyme discovery, enzyme engineering and application to target molecule synthesis. [1-4]
References 1. K. Mitsukura et al., Org. Biomol. Chem. 2010, 8, 4533-4535. 2. G.A. Aleku et al., Nature Chemistry 2017, 9, 961-969. 3. J.R. Marshall et al., Nature Chemistry 2021, 13, 140-148. 4. T.W. Thorpe et al., Nature 2022, 604, 86-91. References: 1) K. Mitsukura et al ., Org. Biomol. Chem. 2010 , 8 , 4533-4535. 2) G.A. Aleku et al ., Nature Chemistry 2017 , 9 , 961-969. 3) J.R. Marshall et al ., Nature Chemistry 2021 , 13 , 140-148. 4) T.W. Thorpe et al ., Nature 2022 , 604 , 86-91.
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