Sustainable ortho-selective alkenylation of 6-arylpurines in Mn(I) catalysis Jang Dongkyu, Jihye An, Hyeonwoong Bae, Juhyun Lee Dong-A University, South Korea Functionalized 6-arylpurine derivatives, widely studied for their potential anti-HCV, cytostatic, and antibacterial activities, have been explored using palladium, rhodium, and cobalt catalysts. In this poster presentation, we introduce ortho -selective C–H alkenylation of 6-arylpurines using terminal alkynes in manganese(I) catalysis. This reaction protocol introduces a sustainable synthetic strategy for ortho -alkenylated 6-arylpurine analogues. Experimental evidences suggest the involvement of five-membered manganacycle intermediate instead of the formation of six-membered complex. References 1. Zhou,; Chen, H.; Wang, C . J. Am. Chem. Soc . 2013 , 135 , 1264−1267.
2. Duan, C.; Liu, X.; Tan, Y.; Ding, R.; Yang, S.; Tian, P.; Lin, G. Synlett, 2019 , 30 , A–G . 3. Wang, S.; Hou, J.; Feng, M.; Zhang, X.; Chen, S.; Yu, X. Commun., 2016 , 52 , 2709—2712.
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