Electrochemical deconstructive functionalization of cycloalkanols via alkoxy radicals enabled by proton-coupled electron transfer Albara El Gehani 1 , Mishra Deepak Hareram 1 , James Harnedy 1 , Alex C. Seastram 1 , Andrew C. Jones 1 , Matthew Burns 2 , Thomas Wirth 1 , Duncan L. Browne 3 , Louis C. Morrill 1 1 Cardiff University, UK, 2 AstraZeneca, UK, 3 University College London, UK We report a new electrochemical method for alkoxy radical generation from alcohols using a Proton-Coupled Electron Transfer (PCET) approach, showcased via the deconstructive functionalization of cycloalkanols. 1-3 The electrochemical method is applicable across a diverse array of substituted cycloalkanols of various ring sizes, accessing a broad range of synthetically useful distally functionalized ketones. The orthogonal derivatization of the products has been demonstrated through chemoselective transformations, and the electrochemical process has been performed on gram scale in continuous single-pass flow. ᵻ References 1. L. C. Morrill et al., Org. Lett., 2019, 21, 9241–9246. 2. R. R. Knowles et al., Chem. Rev., 2022, 122, 2, 2017–2291 3. C. Z ng. et al., CCS Chem, 2021, 3, 1911–1920
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