In vitro Tolerance & Toxicology Establishing the safety and toxicological profile of a cosmetic and its ingredients is the most critical aspect for obtaining regulatory approval. Toxicology testing aims to identify if the cosmetic product or an individual ingredient has the potential to cause harm to an organism.
TOLERANCE & TOXICOLOGY IN VITRO
SKIN SENSITIZATION • DPRA OECD 442C • KeratinoSens OECD 442D • h-CLAT OECD 442E • SENS-IS test on Reconstructed Human Epidermis TOLERANCE TESTS ON MUCOUS MEMBRANES • Oral, gingival, vaginal BIOCOMPATILITY FOR MEDICAL DEVICE • Cytotoxicity ISO 10993-05 • Skin irritation ISO 10993-23 • Skin sensitization ISO 10993-10 • Genotoxicity ISO 10993-03
With more than 20 years experiences on cosmetics, SGS IDEA and SGS IEC assesses the tolerance of cosmetic formulations and toxicity evaluation of cosmetic ingredients, but also of chemical and medical devices. With protocols that follow OECD international guidelines, SGS IDEA and SGS IEC can offer different strategies to assess different toxicological parameters: • Ocular and skin irritation potential
OCULAR IRRITATION POTENTIAL • Agarose gel diffusion test • Neutral Red Release test • Het-Cam
PHOTOTOXICITY • Phototoxicity on fibroblasts (3T3 NRU) OECD 432 • Phototoxicity on Reconstructed Human Epidermis OECD 498 TOXICITY • Acute toxicity test (3T3 model), OECD 129 GENETIC TOXICOLOGY • Ames test (OECD 471) • Micronucleus test (OECD 487)
• Human Corneal epithelium test • (HCE EpiOcular test) OECD 492 • Isolated Chicken Eye Test (ICE) • OECD 438 • Bovine Corneal Opacity and Permeability (BCOP) OECD 437 SKIN IRRITATION & CORROSION POTENTIAL • Skin irritation test on Reconstructed Human Epidermis OECD 439 • Skin corrosion test on Reconstructed Human Epidermis OECD 431
• Phototoxicity • Genotoxicity • Sensitization potential Our capabilities
Made with FlippingBook - professional solution for displaying marketing and sales documents online