The Gittens Clinic October 2019




The Hardest Worker in Stem Cell Treatments EXOSOMES Harboring the power of stem cells is a fantastic scientific achievement that offers multiple benefits. Studies have shown that over one million people in 75 countries have benefited from stem cell treatments. In the U.S. alone, more than 100,000 people have utilized the procedure. Those numbers continue to grow as more people take advantage of the relatively new process. Stem cell treatments can help with a variety of ailments, including spinal cord injuries, burns, heart disease, joint pain, and more. If you’re unfamiliar with stem cells, you may find their origins fascinating. Essentially, they are cells that can develop into many different types of cells. Blood stem cells can be taken from a donor’s bone marrow, from blood in the umbilical cord, or from a person’s circulating blood. Adult stem cells can be found in many adult organs, including bone marrow, peripheral blood, blood vessels, skeletal muscle, skin, teeth, hearts, and livers, just to name a few. However, a critical factor in the conversation around stem cells is often overlooked: exosomes. Exosomes work specifically in mesenchymal stem cells (MSCs), multipotent connective tissue cells present in various adult tissues. Studies have shown that MSCs are beneficial in anticancer therapeutics once exosomes are secreted. Exosomes have various advantages in therapy compared to cells or synthetic nanoparticles that attempt to accomplish the same thing. They can be engineered, are harmless to living tissue, are highly stable, and have a high capacity for carrying various cargoes, like proteins, DNA, and RNA. “Of those benefits, a primary one is that after secretion, MSC-derived exosomes copy characteristics of cells they are exposed to and create more cells of that type.”

However, exosomes are not without controversy; it’s not entirely clear whether MSC-derived exosomes suppress or promote tumor growth, but their

benefits in other regards are undeniable. Of those benefits, a primary one is that after secretion, MSC-derived exosomes copy characteristics of cells they are exposed to and create more cells of that type.

They can be modified with specific binding molecules and proteins on their surfaces to deliver proteins, DNA, or RNA. From there, they can target specific cells and tissues. Furthermore, when these exosomes are isolated during a stem cell treatment process, they will not mirror the properties of disease-ridden or injured cells, so there is no risk of creating more unhealthy cells. This is just a quick breakdown of how exosomes benefit those who use stem cell treatments. Research continues, and more benefits are found every day. If you want more information or have any other questions, feel free to reach out

anytime. Call us at 833-448-8367 to schedule an appointment or visit our Stuart, Miami, or Palm Beach Gardens offices.

-Dr. Carl Gittens


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