HudsonAlpha Research Report 2023-2024

SCIENTIFIC ADVISORY BOARD The HudsonAlpha Scientific Advisory Board is vested with the authority to maintain the Institute’s founding purpose and determine all other scientific matters. A world-class research institute must have a world-class Scientific Advisory Board. Nineuniquely skilled and interna- tionally known investigators have agreed to serve in this capacity. SIOBHAN BRADY, PHD Professor in the Department of Plant Biology and the Genome Center at the University of California, Davis and a Howard Hughes Medical Institute Faculty Research Scholar SCOTT JACKSON, PHD Georgia Research Alliance (GRA) Eminent Scholar in Syn- thetic Biology in the College of Agricultural and Environ- mental Sciences at the University of Georgia TODD JONES, PHD Distinguished Laureate and Pillar Leader for Ag Equity Initiatives at Corteva Agriscience™, located in Johnston, Iowa, USA SHARON PLON, MD, PHD A board-certified medical geneticist and a longstanding researcher in the areas of cancer genetics and Director of the Texas Children’s Cancer Genetics and Genomics Program VAL SHEFFIELD, MD, PHD Director of medical genetics for the University of Iowa and a faculty investigator at the Howard Hughes Medical Institute RICHARD SPRITZ, MD Founder and Director of the Human Medical Genetics and Genomics Program at the University of Colorado School of Medicine LOUISA STARK, PHD Professor of Human Genetics and director of the Genetic Science Learning Center JASON WILLIAMS Assistant Director, External Collaborations at Cold Spring Harbor Laboratory’s DNA Learning Center and Founder of LifeSciTrainers.org BARBARA WOLD, PHD Bren Professor of Molecular Biology and Director of the Beckman Institute at Caltech

TOM MAY, PHD , is a professor of bioethics at the Elson S. Boyd College of Medicine at Washington State University. May earned his PhD in philosophy from Bowling Green State University in 1994, followed by fellowships at the University of Minnesota Center for Biomedical Ethics and in the department of bioethics at the Cleveland Clinic Foundation. He is an expert in bioethics, especially issues

at the intersection of medicine, public health, and moral/social/ political philosophy. May’s primary areas of expertise include ethical, legal, and social implications of genetics, pandemic preparedness and response, and using genomic testing to help adoptees fill gaps in family health history. Another area that May is heavily involved in is how access to the information contained in an individual’s genome could address adoptees’ lack of health history.

XU WANG, PHD , is an associate professor in the Department of Pathobiology at Auburn University. He received a B.S. in Biological Science from the School of Life Science at Fudan University in 2004 and earned a Ph.D. in Genetics and Genomics from Cornell Uni- versity in 2011. His research investigates the genetic and epigenetic regulation of

gene expression in vertebrates and insects with a focus on allelic imbalance, a phenomenon associated with human and animal diseas- es, including cancer, imprinting syndromes, aging, and hypertensive disorders during pregnancy, such as pre-eclampsia. The Wang Lab is working to understand the origin, evolution, and mechanism of allelic imbalance and predict how aberrant patterns of allelic imbalance are associated with disorders in humans and other animals.

RESEARCH REPORT 2023-2024

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