IMPROVING PATIENT CARE WITH EQUINE SERUM AMYLOID A TESTING SIDDRA HINES, DVM, PHD, DACVIM (continued) Any acute inflammatory stimulus can drive SAA production, including intramuscular administration of vaccines or antimicrobials. Maximum levels are reached at 2-4 days post-vaccination and gradually return to normal by 7-10 days. Concentrations typically stay below 500-1000 µg/mL, however some horses (generally young or vaccine-naïve individuals) can reach over 3000 µg/mL while still appearing completely healthy. Significant increases in SAA are not expected strictly due to stress, and physical exertion will cause minimal increase at most. If no confounding inflammatory stimulus can be identified, elevated SAA warrants high suspicion for subclinical disease and further investigation. If reevaluated 24 hours later, SAA should be even higher with an active inflammatory process. 6 HORSE-SIDE RESULTS ALLOW IMMEDIATE TREATMENT DECISIONS Serum amyloid A testing has become more accessible to equine practitioners in recent years with the availability of point- of-care assays. Horse-side quantification of inflammation allows immediate treatment decisions and recommendations for further diagnostics and management, without the delays of lab submission. SAA does not replace a good physical exam, standard bloodwork, or clinical judgment, but adds valuable, objective information to these fundamental tools.
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VMRD SAA test for SerumAmyloidA
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