adult female and male Wistar rats. Using Western blotting, phosphorylation levels of AMPA glutamate receptor type 1 (GluR1) and intracellular signaling molecule ERK were quantified. There was a significant interaction between CFA exposure and acute ethanol to alter ERK phosphorylation in the CeA of male, but not female, rats. Conversely, there was a significant interaction between CFA and acute alcohol to alter GluR1 and ERK phosphorylation status in the female, but not male, insula.
the CeA and insula may contribute to the anti- nociceptive effects of acute alcohol in animals in chronic pain and there may be sex differences in the changes in the brain’s nociceptive systems. Future preclinical investigations in our lab will build on our clinical findings by examining how acute and chronic alcohol regulates HIV-specific pain. This research will help elucidate the mechanism of analgesic action of alcohol in the context of chronic inflammatory pain across sexes with the goal of identifying the corticolimbic system as a novel target for treating pain in AUD patients.
Discussion: These findings suggest that both
UNDERSTANDING PATIENT PERSPECTIVE ON INSTITUTIONAL SPEECH AND SWALLOWING REHABILITATION OUTCOMES IN TOTAL LARYNGECTOMY WITH TRACHEOSTOMY Leigh Hickham, Palak Patel, Jimmy Saravia, Melda Kunduk, Ashley C. Mays; LSUHSC School of Medicine, New Orleans, LA.
Introduction: We seek to understand the relationship between treatment variables and post- operative speech and swallowing rehabilitation after total laryngectomy with tracheoesophageal puncture (TEP) from patient perspective using validated surveys: University of Washington Quality of Life (UW-QOL), Sydney Swallow Questionnaire (SSQ), and Voice Handicap Index-10 (VHI-10). Methods/Results: This is a two-part study approved by LSU IRB. Medical records from January 2013 to January 2022 of patients undergoing total laryngectomy with TEP were reviewed from our two affiliate hospitals: Our Lady of the Lake Regional Medical Center and University Medical Center. First, a retrospective chart review was performed to collect data regarding patient demographics, diagnosis, treatment details, rehabilitation therapy and comorbidities. Second, UW-QOL, SSQ, and VHI- 10 surveys were mailed to patients. Responses were collected via mail and telephone. We identified a total of 138 alive laryngectomy patients, all of whom were mailed the survey. We received 34 responses which were included in the analysis. Each survey response
was converted to a Likert-type item score. UW-QOL identified speech, pain, and swallowing as the three most important issues to patients. The average score for each one of these items was 1.52, 1.21, and 0.78 respectively, from a presumed baseline of 0 i.e., no issues and high scores of 3, 4 and 4 respectively. The overall mean scores were 13.45 for the item-based portion and 4.68 for the general health-related QOL questions. The mean scores for SSQ and VHI-10 were 1.42 and 20.87 with a standard deviation of 1.12 and 20.87 respectively. On cross-analysis with treatment variables, UW-QOL and VHI-10 showed significantly worse outcomes with patient residence >50 miles from treatment facility (p =0.001). No statistical difference was found secondary to need for salvage treatment, adjuvant radiation therapy, method of closure, timing of TEP, and follow-up period. Discussion: Patients living more than 50 miles from the care facility have worse quality of life and voice outcomes. Inclusion of more survey responses will improve the expected effect size, hence, making for higher powered and more conclusive results.
SUCCESSFUL TREATMENT OF CUTANEOUS LEISHMANIASIS WITH CRYOTHERAPY: CASE REPORT Lauren Linquest, Patricia Hickham MD, Leigh Hickham BS, Bayley Richardson BS; LSU Health – Shreveport School of Medicine, Shreveport, LA.
Introduction: Leishmaniasis, a protozoal infection, is a growing health concern with 1.5 million new cases reported annually. There is no consensus on a definitive treatment plan, and current therapies
are high-risk, expensive, and unavailable to most patients. This report supports the efficacy of cryotherapy as a safe, cost-effective, and accessible treatment for cutaneous leishmaniasis. 53
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