Impact Report_2020

IMPACT REPORT

The mission of the HudsonAlpha Foundation is to develop relationships and financial resources to support the work of the nonprofit HudsonAlpha Institute for Biotechnology.

HudsonAlpha Institute for Biotechnology is a nonprofit institute dedicated to developing and applying scientific advances to health, agriculture, learning and commercialization.

a letter from our president

What an incredibly challenging but inspiring year 2020 has been for us all. Science is more important than ever to the health and healing of our world. We are immensely grateful for the resources and support you, our donors, have provided us throughout this year. Recognizing the need for a response to the COVID-19 pandemic, in early 2020 HudsonAlpha pivoted to help find a solution. Both the non-profit research Institute and more than 10 associate companies on the HudsonAlpha campus are working toward solutions to the COVID-19 outbreak with new technology and tools for testing, sequencing, treatment and environmental monitoring. Generosity from businesses, foundations and individuals like you have enabled HudsonAlpha to stay at the forefront of science. Through the stories and statistics in this 2020 Impact Report, we hope to give you a glimpse into how your support is helping people in our community and around the world. These stories also show the support you provide HudsonAlpha is making a real impact on people’s lives. Of course, Alzheimer disease, cancer and environmental challenges don’t stop for a pandemic, so HudsonAlpha’s other operations have continued to move forward in 2020. Despite the economic uncertainty in so many sectors, because of your support, we have been able to maintain our staffing levels this year. A large portion of our workforce spent the last nine months of 2020 working remotely, which created a safer environment for the mission-critical tasks happening in our labs. I have been so inspired by the resiliency of our country and our world. It gives me hope and continues to give me energy to strive toward HudsonAlpha’s vision of creating a healthier, more sustainable world. Thank you for all that you have done to support HudsonAlpha in the past year and thank you for your continued partnership.

Gratefully,

Richard M. Myers, PhD President and Science Director and M. A. Loya Chair in Genomics

Thank you for your generous sup- port of HudsonAlpha’s COVID-19 re- sponse. Because of your efforts, the Institute leveraged more than $800,000 to help find answers and potential treatments for COVID-19, funded critical equipment demands and provided relief to the Institute’s areas of greatest need.

While the world continues the fight against COVID-19, researchers and private industry have banded together in order to slow the spread of the virus and develop new tests and treatments. Now, more than ever, it is evident that collaboration is essential to overcome current challenges. No place is as uniquely qualified to help foster these collaborations than is HudsonAlpha Institute for Biotechnology. At the outset of the COVID-19 pandemic, both the nonprofit re- search Institute and the companies residing onHudsonAlpha’s biotech campus increased laboratory testing capacity, launched point-of-care testing diagnostics, advanced early stage antibody treatments for immune response, provided researchers with critical reagents for COVID-19 projects and sought out new, innovative ideas and research to address the pandemic.

Research Highlights

In 2020, HudsonAlphamade important discoveries inneurological diseases, cancer, childhood genetics, agriculture, basic research and other areas, reflecting the Institute’s commitment to breakthroughs in these fields.

Neurological Diseases HudsonAlpha’s scientific team continues working on neurological diseases by identifying new genetic causes, early detection tools and novel therapies to improve how we diagnose, treat and ultimately prevent diseases like ALS, Alzheimer disease, dementia and Huntington disease. In early 2020, researchers frommultiple international organiza- tions gathered for a symposium to initiate a newmultination- al consortium to expand dementia research in Latin America called Research Dementia Latin America, or ReDLat. The number of people living with dementia worldwide is currently estimated at 50 million and will almost triple by 2050. It is predicted that the increase in cases will be in developing countries where only three percent of demen- tia research currently takes place. More research to develop effective treatments for dementia is needed, particularly

in understudied and diverse populations. Discoveries made through ReDLat will impact patients and families here in the United States and around the world. COVID-19 impacted many projects in 2020, but the ReDLat consortium was able to pivot and modify the project steps by utilizing previously acquired samples to continue making progress in understanding and treating dementia.

Your philanthropy to HudsonAlpha’s Memory and Mobility Program (M&M) made it possible for HudsonAlpha to

memory andmobility program

participate, providing our expertise and leadership in dementia research, sequencing and analysis for this project. It also enabled other projects to move forward focused on solutions for those facing neurodegenerative diseases.

TWO new faculty chair

positions named named cha i rs

To recruit and retain top talent, HudsonAlpha offers the ability to name faculty positions and student fellowships throughout the Institute. Supporting HudsonAlpha through a named position or fund helps strengthen research programs and enables faculty to pursue big ideas. When donors choose to support a naming opportunity, they are making an impactful investment in HudsonAlpha and the future of scientific research or education.

Rick Myers, PhD President and Science Director and M. A. Loya Chair in Genomics

Greg Barsh, MD, PhD Faculty Investigator and Faculty Chair and Smith Family Chair in Genomics

Cancer New strides in local cancer research collaboration

HudsonAlpha is kicking off a collaborative project with Clearview Cancer Institute to study the genes of cancer patients. The project will look at family influences in cancer to learn more about patterns and risk factors. Thank you to Clearview Cancer Institute and the Russel Hill Cancer Foundation for their support of this project.

Your gifts provide hope for new therapies and treatments

Information is Power achieves milestone

Ovarian cancer is both difficult to detect and challenging to treat. HudsonAlpha scientists are targeting chemotherapy cells to signal a response, investigating a treatment that targets a known pathway important in ovarian cancer development and testing new therapies to treat ovarian cancer. In mid-2020, Dr. Sara Cooper’s Lab required a new piece of equipment, a centrifuge to help break down tumor cells. A quick response from donors allowed the lab to purchase this new instrument to continue their work. Your support of HudsonAlpha’s cancer program is vital to helpHudsonAlpha continue to find answers that make a difference. Each day HudsonAlpha scientists strive to find new breakthroughs that will bring health, healing, and hope.

COVID-19 has stopped many things, but it hasn’t stopped cancer. The Information is Power initia- tive Genetics, that screens for the well-known BRCA1 and BRCA2 genes, as well as several dozen other genes linked to breast, ovarian, colon, prostate, pancreatic, andothercancers. In2020, the initiative celebrated a milestone of 5,000 completed tests, giving women and men access to information about their genetic cancer risk to inform health decisions and future planning.

Plant Science and Sustainable Agriculture Philanthropy funds research in agriculture to feed and fuel a growing world

This year brought the expansion of HudsonAlpha’s agriculture program and the establishment of the Center for Plant Science and Sustainable Agriculture.

“The importance of this study is that it helps us understand more about cotton fiber development,” said Jane Grimwood, PhD, faculty investigator. “But perhaps more importantly, it reinforces the surprising concept that wild and domesticated cotton is remarkably similar, leading us to the conclusion that we will need to work on other approaches to generate diversity for cotton species.” Because of your generosity, HudsonAlpha’s Center for Plant Science and Sustainable Agriculture continues to grow and thrive finding new opportunities across the supply chain from farmers and growers to manufacturers and retailers. Expertise that has benefitted researchers around the globe is now supporting projects focused on our local agricultural economy so that Alabama’s farming community can continue to succeed.

Since its beginning 13 years ago, HudsonAlpha has been a leader in de novo genome sequencing, the process of obtaining an entire genetic makeup of a species. Four years ago, the group expanded with the addition of a faculty member experienced in biofuels. Now with two new faculty investi- gators added to the team, the program is adding botany and crop improvement capabilities. Cotton is the most valuable crop in Alabama with more than 500,000 acres planted each year. To improve the cotton crop, HudsonAlpha was part of a recent project to sequence and assemble five different cotton genomes to identify differences among wild and domesticated cot- ton that could be used to bring back traits like disease or drought resistance. The newly assembled genomes will lead to advances in cotton sustainability.

N E W F A C E S

We are growing because of you!

Growing scientific expertise - Meet our newest faculty

Josh Clevenger, PhD, is a faculty investigator at HudsonAlpha Institute for Biotechnology. His research focuses on using genomics for crop improvement for sustainable agriculture, especially crops in the southeast and Alabama. Clevenger earned his PhD in Plant Breeding, Genetics, & Genomics from the University of Georgia. He came to HudsonAlpha fromMars-Wrigley’s nut science team where he developed and deployed genetic improvement projects for key peanut supply origins. “Our hope is to bridge the gap between science and nature by more rapidly deploying beneficial traits into cultivated crops farmers can plant on their land. To do this, we will develop better computational tools to help identify selection markers for beneficial traits, and new, rapid breeding practices to introduce these markers into existing crop lines.”

Alex Harkess, PhD, holds a joint position as faculty investigator at the HudsonAlpha Institute for Biotechnology and assistant professor in the Department of Crop, Soil, and Environmental Science at Auburn University. His research focuses on plant reproductive, evolutionary and comparative genomics. Harkess earned his PhD in plant biology from the University of Georgia. He

was a National Science Foundation Postdoctoral Fellow at the Donald Danforth Plant Science Center in St. Louis, conducting research focused on the evolution and function of small RNA pathways, the evolution of sex chromosomes in plants, and broad-scale comparative genomics. “We’re a basic biology lab and we study the ways across the tree of life that plants have evolved to reproduce differently. And once you do that, once you map out all of the ways a plant can differently reproduce sexually or asexually, then you can start to engineer those kinds of changes into crop plants.”

This past academic year, thanks to your support, Educational Outreach reached an astonishing 1.96 million students, teachers, members of the public, and healthcare professionals. Your generous donations provided educational tools to teachers and students to train the next generation of STEM leaders. Childhood GENETiC disorders Hope in a name - Violet’s story In the beginning, Violet could only say a few words like momma, dadda and bubba. Around eight months of age, she started to show signs of regr ssion in her development. Her pare ts began asking questions of her doctor and going to therapy sessions. Violet remained a quiet little mystery. After two and a half years of searching, along withmultiplemedical appointments, Violet was diagnosed with Rett Syndrome through HudsonAlpha Institute for Biotechnology’s childhood genomics program. Viol t’s family still faces challenges every day. While her diagnosis has led to support group connections and visits with top Rett Syndrome specialists to find the best treatment path for Violet, they still have a journey ahead.

THANKS TO YOU...

Helping children and their families nd answers

enrolled families

1424

sequenced genomes of children

But Violet’s hope for a better future is stronger thanks to the diagnosis and answers she received fromHudsonAlpha.

submitted genes to GeneMatcher

seeking answers through worldwide connections

Numbers reect totals since the beginning of the program. 18 collaborative publications (since 2016)

Impact through education

Educating through COVID-19 To help make sense of the science related to the coronavirus COVID-19 and to address much of the misinformation associated with the pandemic, Dr. Neil Lamb developed a new series of videos, called Shareable Science: Beyond the Blog, that have become a trusted source of accurate and timely information about COVID-19 for more than 100,000 individuals in our community and beyond. In April, the Educational Outreach team launched Learning Together Apart 2020, an online portal to help parents and teachers educate students during the COVID-19 pandemic. The resource includes digital copies of activities, videos, and educational support materials with new content being added. Beacon: Biology at a Distance is another tool that was designed to help teachers adjust to the new educational landscape brought on by the COVID-19 pandemic. Beacon helps educators find life science content from a distance and offers technology integration and best practices for virtual delivery of lessons. This past academic year, thanks to your support, Educational Outreach reached an astonishing 1.96 million students, teachers, members of the public, and healthcare professionals. Your generous donations provided educational tools to teachers and students to train the next generation of STEM leaders.

Dr. Neil Lamb appointed to lead Governor Ivey’s STEM council Science, technology, engineering and mathematics workers play a key role in the sustained growth and stability of Alabama’s economy. As companies continue to relocate or expand in Alabama, the state must develop an adept workforce that is prepared to adequately meet growing labor demands. The Governor’s Advisory Council on STEM was established to advise state leadership on ways to improve STEM-related educa- tion, career awareness and workforce development opportunities across the state. Dr. Neil Lamb, vice president for Educational Outreach at HudsonAlpha, will be chairman of the new council. “Our great state is home to several quality STEM-focused education and workforce initiatives. However, we lack a common system to weave these initiatives together into a network that reaches all learners across the state and expands the workforce pipeline,” Dr. Neil Lamb said. “Establishing a statewide Council was a key recommendation from the Governor’s Advisory Council on Excellence on STEM, and I am thrilled to see that recommendation become reality through the Alabama STEM Council.”

When the world changed due to the COVID-19 pandemic, HudsonAlpha’s Educational Outreach team pivoted to provide instructional support, digital learning tools, and on-demand lessons for both teachers and parents struggling to continue STEM learning in a virtual environment. YOUR GIFTMADE IT POSSIBLE.

Genomic health Collaborative pilot projects kickoff

“Physicians know that establishing a diagnosis is essential to choosing or developing a treatment,” said Bick. “Our purpose is to bring genomics into the practice of medicine so physicians have more effective tools to identify and understand the underlying causes of disorders.”

The HudsonAlpha Health Alliance, under the direc- tion of Dr. Devin Absher, faculty investigator and di- rector of genomic health, has begun work with East Alabama Medical Center, Auburn University and the Muscogee Creek Nation. EAMC and Auburn University are offering pharmaco- genetic testing to their employees as a wellness benefit. The Muscogee Creek Nation project will provide pharmacogenomics, heritable genetic disease screening and educational programs to thousands of their citizens. Smith Family Clinic celebrates five years When the Smith Family Clinic for Genomic Medicine opened in 2015 on the HudsonAlpha Institute for Biotechnology campus, it was the one of the first clinics in the world to use genomic sequencing technology to findanswers for rareundiagnosedandmisdiagnoseddiseases. Ledbymedical directorDavidBick,MD, the clinic seesmore than300patients eachyear andcontinues to findanswers for patients with rare undiagnosed and misdiagnosed diseases. Patients are seen by the clinic staff who evaluate symptoms, orpatient phenotype, anddeterminewhetherwhole genome sequencing is anappropriate test.Thedata fromthegenomic sequence is then interpreted clinically to identify variants, or changes in theDNA, linked to disease.

To support thework of the Smith Family Clinic, the HudsonAlpha Foundation established a patient assistance fund, named the Hero Fund, thanks to an anonymous donation. The Hero Fund helps patients at the Smith Family Clinic who need, but cannot afford, access to genomic medicine. your gifts gave 32 patients hero fund assistance.

HudsonAlpha Founders Lonnie S. McMillian • Jim Hudson Institute Board of Directors

Alumni Association Pamand Joe Alexander Jenny andTimBachmann Annie and Pete Brasseale Stacey Brewer Elsie andCharlie Brown Burnett-NickelsonFamily Fund Sue andRandyCampbell Kathy andCH 'Tony' Chan Cindie and JohnChapman VoncilleCleary Sara andCharlieCrocker PaulaCushman Edna and JeroldDeener DianDerrick BobDoehrman

Mary andDavidLamb Terry andHerbLewis Nancy andRandyMartin Christel andGeorgeMcCanless Jean andMacMcCrady Shirley andGeorgeMcCrary Ginney and FosterMcDonald HelenMcMillian CarolMeekins Tara, Jeff, and JazmineMello Catherine andKenMontgomery Elizabeth andMichaelMorard Carolyn andClarkOwen Mary Lee andLee Prout Jennifer Riggs-Sauthier and Marc Sauthier Emily and Steve Robertson Nancy Rohr Becky andLarry Ruhlman

Dick Fountain Nancy and Phil Grubbs PatriciaHair

Becky and JimSchaaf Nancy Sheppard Leslie and Patrick Shields Sangeeta andAshok Singhal Linda Smith Susan andBill Sommers Loretta Spencer Brenda Tapp JeanWessel Templeton Susy andBobThurber Brenda andDickTitus Irma and JackTuder SallyUpchurch GusWeisler Judy and SidneyWhite JenniferWu andChris Sanders Allen andTomYoung

Debra andDeanHallmark Ona and JohnHamilton JaneHays Peg andBuzzHeeschen Barbara Paul andTomHickerson Chris andBobHinson RoslynHonan Lynn and JimHudson Jennie and JimmyHudson Cindy andRichard Jackson Norma Jensen Chris andBill Johnson Ruth Jurenko SarahLauren andAndyKattos Pennie andTomKeene HopeKinch

Barbara Fisk Paul Gierow Milton Harris Jim Hudson Sam McManus Brian Pollock

Bob Riley Gene Sapp Linda J. Smith

Irma Tuder John Wynn

foundationBoardofDirectors Marc Bendickson

Bob Riley Emily Robertson

Bobby Bradley Sue Campbell Barbara Fisk Cindy Gray Peter Lowe David Lucas Foster McDonald

Chris Russell R. Gary Saliba John Shields JeanWessel Templeton Karen Thomas

Lucia and SamEidt Lue andBill English Mack Ennis Barbara andTimFisk

ambassadors Pam Alexander Rose Allen Cynthia Almodóvar Rob Baron

Connections Mae Adams Josh Adams Katelyn Baker Laura Best Will Best Ray Brown Jennifer Buckner Caitlin Campbell Dana Cave

Eleanor Loring John Malone D.D. Martin Ben Matthews Bob McCaleb Shirley McCrary Hal Mooty Elizabeth Morard Joe Newberry Mary Lee Prout Paige Prozan Jim Rogers Chris Russell Nancy Sheppard

Nicholas Rockhill Emily Rogers Michelle Rudd Joe Salls Zach Sullivan George Twitty

Justin Johnson Caroline Kennedy Jason Landers Nick Lasater Ryan Letson James Lomax Emily Mason Markeeva Morgan Charles Nelson

Robyn Comer Vincent Cooper Lauren Dauro Drew Davenport BJ Davis Kevin Fernandez Brad Garland Tiffany Gayman Stephen Gunter

Chad Odell Matthew Parker Taylor Propst Will Pylant Nicholas Ranta April Reed Matt Reed Amy Roark Kaitlynn Roark

Bobby Bradley Julie Broadway Wes Clayton Lynn Collyar Xan Curran

Victor Vega Rob Warren

Kerry Fehrenbach Margaret Gleason Gene Goldman Jeff Gronberg Liz Hurley Hargrove Jane Hays

Pat Shields AJ Singhal Beth Sippel Lisa Stone Norm Tew

Hank Isenberg Debra Jenkins Andrea Jones Carole Jones Tracy Jones Michelle Jordan Andy Kattos Pennie Keene

Professional Advisors Council Liz Abel

Alex Pols Paula Renfroe Chris Russell Mike Segars Tim Sieja Brandy Smith Chris Smith Cindy Smith Jessica Smith

Grant Thomson John Watts Amanda Weaver Ray White Greg Whitehead Mike Wisner Lori Womack

Kevin Fernandez Dick Fountain Paul Frederick Ginger Harper Stephanie Hendon Brian Hinson Chris Hinson Lee Hoekenschnieder Joy Howard

Brittany Irons Mike Johnston Brian Jones Charles Jones James Lancaster David Little Scott Ludwig Doug Martinson, II Todd McBride

Judy Thomas Bob Thurber Lynn Troy Karockas Watkins Peri Widener Daniel Wilson

Heather Adair Tom Albright Gary Anglin Alan Bibb Jack Burwell Joe Campbell Moss Crosby Daryl Davis

Robert Key David King Sherry Kolodziejczak Karl Leo Kim Lewis

Wendy Yang Tom Young

lifetime giving We would like to extend our deepest thanks to the following individuals, corporations and foundations for their extraordinary generosity. These members have cumulative lifetime giving of $10,000+ in contributions and planned gifts. Chairman’s Council $500,000+ Alpha Foundation, Inc. Anonymous Sue and Randy Campbell

Sangeeta and Ashok Singhal Janice Smith Loretta Spencer St. Baldrick's Foundation Teledyne Brown Engineering, Inc. Jean Wessel Templeton Irma and Jack Tuder Wayne, Luanne, and Peri Widener Fund for the Study of Neurodegenerative Diseases Innovator $25,000+ Alfa Foundation Cynthia and Rey Almodóvar ALS Association American Association for Cancer Research American Cancer Society, Inc.- Huntsville AnglinReichmannArmstrong, PC Aviagen North America, Inc. BBVA Compass Foundation Ben May Charitable Trust Sheryl and Marc Bendickson Brasfield & Gorrie Traci and Steve Breland Laura Crandall Brown Ovarian Cancer Foundation Burnett-Nickelson Family Fund The Caring Foundation of Blue Cross and Blue Shield of Alabama Century Automotive CFD Research Corporation City of Huntsville, Alabama Clearview Cancer Institute Marie and P. Michael Cole

Breast Cancer Research Foundation of Alabama BrightFocus Foundation Chris Brown Kathy and CH 'Tony' Chan James R. and Voncille J. Cleary Fund for Neurological Research Cotton Inc. Fred Craves The Daniel Foundation of Alabama Estate of Tony DiCerbo Dynetics, Inc. EBSCO Industries, Inc. Estate of Nola and Frank J. Eiser GATR Technologies iRepertoire Cindy and Richard Jackson Ruth Jurenko Jane K. Lowe Charitable Foundation Mei Lu and Jian Han Madison County Commission Shirley and George McCrary Ginney and Foster McDonald Estate of Ruth and Foster Oliver The Peanut Foundation Beth and Hank Pearce Quarterbacking Children's Health Foundation Redstone Federal Credit Union Russel Hill Cancer Foundation ServisFirst Bank Nancy and Ray Sheppard Patsy and John Shields

Anonymous Pam and Joe Alexander Nancy andDanny Archuleta Likewise, the Double Helix Society is the foundation of HudsonAlpha’s future, ensuring a steady stream of charitable revenue for years to come. These planned gifts perpetuate donors’ commitments to HudsonAlpha’s mission well into the future. Thank you to these special members: Terry and Herb Lewis Helen and LonnieMcMillian Sandy Moore Sue and Roy Nichols Estate of Ruth and Foster Oliver Pat and Gene Sapp Elizabeth and Clarence Schrader Nancy and Ray Sheppard Johanna Cleary Voncille Cleary Harvey Cotten Paula Cushman The Double Helix Society refers to the DNA double helix, the twisted double-stranded molecular structure that codes all of life. DNA is the foundation of the dynamic research underway at HudsonAlpha as scientists strive to improve human health and quality of life through genomic research, economic development and educational outreach.

CHDI Foundation Inc Barbara and Tim Fisk Lynn and Jim Hudson Susan G. Komen Breast Cancer Foundation Inc

The Leo Fund The Lilly Fund Mike Loya Helen and Lonnie McMillian Sue and Roy Nichols Peter Pratt Family Fund Pritzker Philanthropic Fund Eloise and Bill Propst Emily and Steve Robertson Mark C. Smith Family Foundation Clay Smith Linda J. Smith Visionary $100,000+ ADTRAN, Inc. Alabama Power Foundation Pam and Joe Alexander The American Chestnut Foundation Anonymous Anonymous James Cecil and Margaret G. Ashburn Foundation The Boeing Company Bradley Arant Boult Cummings, LLP - Huntsville

Edna and Jerry Deener Estate of Tony DiCerbo Sharon Doviet and Chris Russell Estate of Nola and Frank J. Eiser Jency Eldridge Kathy and Steve Gilder Ona and John Hamilton Dorcas Harris Lynn and JimHudson Carole and George Jones

Patsy and John Shields Susan and Bill Sommers Lynne Berry Vallely Charles Vaughn Jane and Frank Vaughn Gus Weisler Pamela Barratt White Leslie and Danny Windham Wendy Yang and Rick Myers

3M Linda and Rob Akenhead Alabama Media Group Alliance Cancer Care Alpha Tau Omega Fraternity-UAH Sustainer $10,000+

Pearce Construction Company, Inc. Jean and Jerre Penney Progress Bank and Trust Radiance Technologies, Inc.

Margaret and Hugh Mackie Maynard Cooper & Gale, PC Jean and Mac McCrady Merrill LynchWealthManagement Mike&GillianGoodrichFoundation Elizabeth and Michael Morard / Qualis Corporation Nancy Moss Family National Defense Industrial Association Nektar Therapeutics NorthropGrummanCorporation The Partesotti-Siniard Memorial Fund Brian and Kelly Pollock The Prevent Cancer Foundation Mary Lee and Lee Prout Heather and Dale Qualls Regions Bank Nancy Rohr Rosie's Mexican Cantina Nancy and Gary Saliba Richard Saperstein / Treasury Partners Pat and Gene Sapp Amanda and Rob Seitz Serina Therapeutics, Inc. Leslie and Patrick Shields Betty and Bill Sims Solve ME/CFS Initiative Synovus Bank Susy and Bob Thurber Toyota Motor Manufacturing Alabama, Inc. Sally Upchurch Van Valkenburgh & Wilkinson Realtors Vulcan Materials Company Foundation Wells Fargo Wells Fargo Foundation Christine and Mike Wicks Willbrook Solutions, INC. Leslie and Danny Windham Wendy Yang and Rick Myers Allen and Tom Young

COLSA Corporation Lyn and John Cook, Jr. Bud Cramer

Mary Alice and Emerson Fann Nancy and Jerry Fishman Ellen and Vincent Forlenza Fraternal Order of Eagles Aerie 3263 - Ladies Auxiliary Margaret and Jack Gleason Glen Research Corporation Goldman Sachs Google Fiber Sarah Green and Lynn Collyar Dorcas Harris and Dick Reeves Linda and Norm Harris IronMountain Solutions, Inc. ISSAC Corp J. Smith Lanier & Co. Coy Jackson Jerry Damson Honda Acura Chris and Bill Johnson Kailos Genetics The Keene Group at UBS Financial Liz and Jim Kennedy Cynthia and Neil Lamb Alice and Frederick Lanier

Margaret and David D'Amico Leta and Mike DeMaioribus DESE Research, Inc. Dimesol Discovery Life Sciences Lue and Bill English Yulia and Mark Faist Dick Fountain Fraternal Order of Eagles Aerie 3263 Fuqua and Partners Architects, PC Sarah and Carl Gessler Cindy and Ron Gray Susan and Tom Griffith Ona and John Hamilton Kathy Hart Jane Hays Peg and George Heeschen Hexagon Intergraph HighTower Twickenham Andi and Steve Hill h2O4Christ Foundation Fund Jennie and Jimmy Hudson Cynthia and Jim Hughes Huntsville Hospital Illumina, Inc. Intrepid Carole and George Jones Libby and Ray Jones Sarah Lauren and Andy Kattos Keel Point, LLC Pennie and Tom Keene / The Keene Group at UBS Financial Hope Kinch The Olin B. King Foundation Wallace Kirkpatrick Kord Technologies, Inc. Lanier Family Foundation Lanier Ford Terry and Herb Lewis Lockheed Martin Corporation

Renasant Bank Paula Renfroe

Catherine and Arthur Rollins Carolyn Russo and Greg Barsh Jean and Bill Salter Samples Properties, Inc. Schoel Engineering Lucinda and Marshall Schreeder Donna and Bill Shergy Mrs. William Sims Allison and Josh Solomon Connie and Rusty Stephenson Sharon and Rick Suever SystemDynamics International, Inc. System, Studies & Simulation, Inc. Sherry Taylor Donna and Howard Thrailkill Torch Technologies, Inc. Treasury Partners Troy 7, Inc. TSA Mike Turner UAH College of Science Valent Group Nancy and Richard Van Valkenburgh Venturi, Inc. Warren Averett, LLC Wayne's Acoustical and Drywall, Inc. Gus Weisler

Anonymous Anonymous Nancy and Danny Archuleta Available Plastics, Inc. Bahwan CyberTek Phylis and Bob Baron BBVA Compass Bank Sylvia and Charles Betts Alka Bhargav and Raj Khanijow Bill Penney Toyota Blue Cross and Blue Shield of Alabama Janet and David Brown Bryant Bank C&A Printing Donna and Van Cancel Glynda Cavalcanti Celsion-EGEN, Inc.

Leo Law Firm, LLC Judy and James Link Ann Livingston Longview Financial Advisors, Inc.

CenterState Bank Alice Chenault and Milton Harris

City of Decatur, Alabama City of Madison, Alabama Frances and Wes Clayton Corporate Dining Concepts Crestwood Medical Center Philip Crosby Cummings Aerospace Paula Cushman Vella Dailey Edna and Jerry Deener Deloitte Consulting, LLP Diatherix Laboratories, LLC

Cindi and Bob Ludwig Kathy and Scott Ludwig The Thomas Main Family Fund Scarlett and Brian Mathews Christel and George McCanless Ann and Wayne McDonald Lynn and Sam McManus McWane Foundation The Mevatec Foundation Connie and Jerry Moore Randall Moreadith Morgan Stanley: The Shields Group Nucor Steel Decatur, LLC Susan Ozment Parker Griffith Family Parkinson's Support Group of Huntsville, Inc.

Juliet and Carter Wells Judy and Sydney White Pamela Barratt White Andy Whitehead

Digium, Inc. Martha Dolan Kathleen Dotts ERC Helping Hands Nell Evers

Betsy and Peter Lowe Lyndhurst Foundation

annual giving Gifts of all levels enabled us to continue building momentum, making incredible progress in our mission. Donors who make annual gifts of $1,000 and above are included in the Genome Circle, HudsonAlpha’s major giving program. All Genome Circle members are also recognized for their generosity on the Giving Wall in the atrium of HudsonAlpha’s main building. This list reflects gifts received as of January 8, 2021. In 2020, more than 1,700 individuals, corporations and foundations supported HudsonAlpha with their generosity.

Alpha Foundation, Inc. Anonymous CHDI Foundation, Inc. The Leo Fund The Lilly Fund Mike Loya Peter Pratt Family Fund Pritzker Philanthropic Fund Chairman’s Council $500,000+ Beth and Hank Pearce Visionary $100,000+ Innovator $25,000+ Bud Cramer Fred Craves Madison County Commission Quarterbacking Children’s Health Foundation Russel Hill Cancer Foundation Nancy and Ray Sheppard Teledyne Brown Engineering, Inc. Jean Wessel Templeton Sally Upchurch Wayne, Luanne, and Peri Widener Fund for the Study of Neurodegenerative Diseases Willbrook Solutions, INC. Allen and Tom Young ADTRAN, Inc. Alfa Foundation Anonymous BrightFocus Foundation

Century Automotive Kathy and CH ‘Tony’ Chan City of Huntsville, Alabama Frances and Wes Clayton Voncille Cleary Lyn and John Cook, Jr. Cindy and Ron Gray

Elsie and Charlie Brown Janet and David Brown Bryant Bank Carole and Tom Bryant Doris Burwell Foundation BWX Technologies, Inc. Rick Byrn Joe Campbell Donna and Van Cancel Canvas, Inc. CenterState Bank Cepeda Systems & Software Analysis, Inc. CFD Research Corporation Cindie and John Chapman Alice Chenault andMiltonHarris Johanna Cleary Elizabeth and Francis Cline Clinic for Women, P.A. Meagan and Nick Cochran Marie and P. Michael Cole Elaine and Mitch Coley Corporate Dining Concepts Corporate Office Properties Trust Cotton Inc. Crestwood Medical Center Cubic Corporation Jim Cunningham Paula Cushman Margaret and David D’Amico Vella Dailey RicheleJordamDavisandDarylDavis Edna and Jerry Deener Kari and Dan DeGrandpre Helen and Lynn Deibler Leta and Mike DeMaioribus DESE Research, Inc. Discovery Life Sciences EBSCO Industries, Inc. Melissa and Mike Edwards Jency Eldridge and John McCoy Nell Evers Nancy and Jerry Fishman Barbara and Tim Fisk Five Stones Research Corporation FraternalOrderofEaglesAerie3263 Fraternal Order of Eagles Aerie 3263 - Ladies Auxiliary COLSA Corporation Sara and Greg Cooper Fay and John Copeland Kathleen Dotts Naomi DuBois Dynetics, Inc.

Wilma Frazier Frogg Toggs Eve Garriott Sarah and Carl Gessler GFWC du Midi Woman’s Club Kathy and Steve Gilder Margaret and Jack Gleason Goldman Sachs Paul and Patsy Gray Jane Grimwood and Jeremy Schmutz Clare and Mike Grisham Patricia Hair Laura Jo and George Hamilton Ona and John Hamilton Lori and Paul Handley Dorcas Harris and Dick Reeves Natalie and Darrin Hasley Patsy and Larry Havard Samuel Havely Elizabeth Haynes Elizabeth and Blake Herrin Bonnie and Steve Hettinger Hexagon Intergraph Hiley Huntsville Jane Hill Hinson & Hinson, PC h2O4Christ Foundation Fund Christy and Lee Hoekenschnieder Betsy and Ed Holland Roz Honan Joanne and Lou Horn Sandy and Bob Hovde Jennie and Jimmy Hudson Frances Huffman Huntsville Hospital Huntsville Hospital Clinic for Breast Care Huntsville Hospital Corporate Wellness Huntsville Tractor & Equipment i3 Cares iCubate, Inc. Imagehawk, Inc. Inspire and Achieve Foundation InterFuze iRepertoire IronMountain Solutions, Inc. Karen and Paul Israel J. Smith Lanier & Co. Jackson Center Cindy and Richard Jackson Jerry Jennings Jerry Damson Honda Acura

Johnson Partners, Inc. - McDonald’s Chris and Bill Johnson Andrea and Charles Jones Keel Point, LLC Pennie and Tom Keene - The Keene Group at UBS Financial Hope Kinch Shelbie King Michael Kirkpatrick Claudia Klus Kord Technologies, Inc. Rodney Kreps Vicki and Rich Kretzschmar Leslie and Tim Kelley Liz and Jim Kennedy Cynthia and Neil Lamb Mary and David Lamb Lanier Family Foundation Ann and James Ledbetter Leo Law Firm, LLC Karl and Fay Leo Lewis Properties, LLC Kim and Larry Lewis Nita and Jim Lewis Lexus of Huntsville Judy and James Link Ann Livingston Lockheed Martin Corporation Madelene Loftin LogiCore Corporation Longview Financial Advisors, Inc. Jean and Peter Loux Cindi and Bob Ludwig Elaine Lyon MadisonCounty Medical Alliance Nancy and Randy Martin Suzanne and Ben Matthews Christel and George McCanless Genie and Bill McCoy Ann and Wayne McDonald Lynn and Sam McManus McWane Foundation Merrill LynchWealthManagement D.D. Martin Jan and Les Miller Ila Mitchum ModernTechnology Solutions, Inc. Catherine and Ken Montgomery Katie and Hal Mooty Elizabeth and Michael Morard- Qualis Corporation Michele and Lance Morris MVW Nutritionals

Benefactor $1,000+ Advanced Life Clinic Air, Space and Missile Defense Association (ASMDA) AlabamaPsychological ServicesCenter, LLC Alliance Cancer Care Cynthia and Rey Almodóvar AnglinReichmannArmstrong, PC Anonymous Raechel Armstrong Jenny and Tim Bachmann Balentine Wealth Management Amity and Robert Baron Sheryl and Marc Bendickson Sylvia and Charles Betts Bill Penney Toyota Penny and Jay Billings Tammi and Jim Bolte Bonaero, Boneal Aerospace, Inc. Amber Brookman and Devin Absher Kakki and J. R. Brooks Kay Brotherton Susan and Tom Griffith Peg and George Heeschen HighTower Twickenham ISSAC Corp Carole and George Jones Wallace Kirkpatrick Terry and Herb Lewis Margaret and Hugh Mackie Morgan Stanley: The Shields Group Burnett-NickelsonFamilyFund Northrop Grumman Corporation The Partesotti-Siniard Memorial Fund Rosie’s Mexican Cantina Pat and Gene Sapp Patsy and John Shields Loretta Spencer Synovus Bank Sherry Taylor The Thomas Main Family Fund Susy and Bob Thurber Christine and Mike Wicks

Sustainer $10,000+

ALS Association Anonymous

James Cecil and Margaret G. Ashburn Foundation Aviagen North America, Inc. Bahwan CyberTek Bradley Arant Boult Cummings, LLP - Huntsville Brasfield & Gorrie Sue and Randy Campbell The Caring Foundation of Blue Cross and Blue Shield of Alabama

Nikki Mertz Brooks Moore Sandy Moore Tom Morris

Debra and Dean Hallmark Liz Hurley Hargrove and David Hargrove Kim and John Hartley Liz and William Herrin Chris and Bob Hinson Katherine and Ed Hinson Rita and Charlie Horton Hospice of North Alabama Mary and Cutter Hughes Marilyn and Richard Hull Huntsville Pediatric Associates Huntsville STEAM Works Jennifer Hutchison Paul Icolano Intuitive Research and Technology Corporation Coy Jackson Norma Jensen Kailos Genetics Kiwanis Club of Huntsville - Golden K LuAnn Lusk Chris Manley Patti and Don Marsh Matthew’s Mission Tara and Jeff Mello The Merck Foundation Julia Michaux-Watkins Elizabeth and Bert Moore Kim and Scott Newberry Melissa Kronk Ginger Loder Newcomers Club of Greater Huntsville John Ofenloch Carolyn and Clark Owen Chris Partridge Barbara Paul and Tom Hickerson

Candace Allen Courtney and John Allen

Townhouse Galleries Treasury Partners Trideum Corporation Jay Trowbridge Troy 7, Inc.

National Defense Industrial Association

Linda Allen Anonymous Shirley Azbell

National Space Club Nektar Therapeutics

Caroline and Jay Myers Linda and Jay Newkirk Darrell Newman Christy Odom Marylin Passino

Nesin Therapy Services North Alabama Chemical Cathy and Greg Oelberg Outpatient Diagnostic Center Susan Ozment Pacific Biosciences Caroline Page Lisa and Kapil Pant Parker Griffith Family Parkinson’s Support Group of Huntsville, Inc. Pearce ConstructionCompany, Inc. Katie and Louis Perkins Norma Perry Smitha and Tarek Persaud Lois and Bill Pope Progress Bank and Trust Mary Lee and Lee Prout Radiance Technologies, Inc. Radiology of Huntsville Redstone Federal Credit Union Paula Renfroe Lindsay and Bradley Rice Nina and Terry Roberts Emily and Steve Robertson Reba and Jim Rogers Nancy Rohr Sherri and David Romanoff Carolyn Russo and Greg Barsh Nancy and Gary Saliba Jean and Bill Salter Timo Sandritter Richard Saperstein - Treasury Partners Rebecca and Thomas Satterfield Marie and Bill Schneider Schoel Engineering Lucinda and Marshall Schreeder Tammi and Wayne Scruggs Serina Therapeutics, Inc. ServisFirst Bank Kathy and Andrew Shea Donna and Bill Shergy Leslie and Patrick Shields Simtech, Inc. Anne and Roger Smalligan Karen and James Smelser Susan and Bill Sommers Tara and Michael Speigle SystemDynamics International, Inc. Carol and Jim Tevepaugh Kathi and Norm Tew Karen Thomas Amy Thornton Donna and Howard Thrailkill Brenda and Dick Titus Torch Technologies, Inc. Linda J. Smith Rosalie Smith

Aaron Bankhead Winifred Beason Emily Berlin Pat and Jim Blair Lori Boston Peggy Boynton and Adam Hott Allison Brown Diane Brown Candy and John Burnett Sharon Butler Christen Cantrell Jennifer and Ashley Carden Ashley and John Clark Grace Clark Michael Cosgrove Terence Cunningham Karen and Manh Dang Linda Davis Amelia Denslow Dian Derrick Peggy and David Deutch Bob Doehrman Kelly and Andrew East Mack Ennis Alison Fields James Fisher Mike Frizzell Asa Gilliland Mary and Charlie Grainger Nancy and Phil Grubbs Tish and Morris Hammer Jane Hays Katie Herr Susan and Josh Hiatt Matt Holt Melea and Charles Horton Richard Johnson Teresa and Norman Johnson Katherine and Jeff Karlinger Sarah Lauren and Andy Kattos Tara and Jacob Kelly Caroline and Logan Kennedy Mike Johnston Karol Kapustka Ruth and Robert Key Frances and Jeff Kyser Andrea and Jason Landers Patricia Ann Layky Renata Limmer Virginia and Bill Love Rebecca Loya Linda and Don Maccubbin Debbie Malone Laura and Darren Malone Robyn and David Mann Aaron Margulies Rebekah McMackin Jessica Merritt

Ann and Larry Tubbs Irma and Jack Tuder UAH College of Business Administration UAH College of Science Brooke and David Uptagrafft Valent Group Van Valkenburgh & Wilkinson Realtors Nancy and Richard Van Valkenburgh Warren Averett, LLC Watermark at Bridge Street Town Centre Wayne’s Acoustical andDrywall, Inc. Patty and Glenn Webb Gus Weisler Wells Fargo Foundation Juliet and Carter Wells Debbie and Larry West Judy and Sydney White Lia and Ray White Diane Wick Rachel Philip Wiles Leslie and Danny Windham Quatina M. Wolaver Foundation of Hope Women4Women Wendy Yang and Rick Myers patron $500+ Aerojet Rocketdyne Frances and Scott Akridge Alabama Colon and Gastro, P.C. Pam and Joe Alexander Anonymous Mark Bass Jackie and Tom Berg Mike Berkholtz Martha and Charles Betts Ilsa and David Bick BMSS Advisors & CPAs, LLC Lara and Ben Burhenn Marianne and Carl Case Crystal and Scott Couch Decatur Morgan Women’s Healthcare Julie Detrick Margaret and Ricky Dockins Draper Theresa and Mike Durboraw Lucia and Sam Eidt Janet and Derrel Emmerson ERC, Inc. Mary and Gene Ezell Four Seasons Garden Club Mary and John Bowman Annie and Pete Brasseale Stacey Brewer Mike Bryan Cindy and Steve Burcham

Martha and Doug Patz Dale and Richard Peters Lillie Pike Paige and Jeff Prozan Helen Purcell Melba and Everette Ramage Regina and Jon Randel Allyson Rawlinson Tamara and Reginald Robinson Becky and Larry Ruhlman Mark Saliba Becky and Jim Schaaf Peg and Norman Skrenes Jun Song Lana Jo and Richard Spera Liz and Bob Stagg Aida Starling Sharon and Ray Steelman Ada Stewart Amanda Stokes Amy and Charles Sturdivant Brett Sundlof Liz Switzer Brenda Tapp Lynn and Paul Wagner Nancy Westfall Stephanie and Phillip Whitlow

Jackalyn Wilcox Knox Williams Amy Wills

Robert Wooldridge Liz and Steve Wright

Bonnie Pearson PeopleTec, Inc.

Jennifer Wu and Chris Sanders Cindy and Roderick Zalamea Beth Zinn

Karen and David Petersen Redstone Harley Davidson Jennifer Riggs-Sauthier and Marc Sauthier

Ann Rivard Salon Allure

Stephanie Sherman Betty and Bill Sims Jody and Chris Singer Siniard, Timberlake & League, P.C. Beth and Dave Sippel

Cathy Sloss Jones Bobbye Thompson Janet and Buck Watson Dana Watts Jeanetta Wilson Irene and Mike Wisner Mary Ruth Yates friend $250+ Debbie and Paul Agarwal

Employees of HudsonAlpha have the power to give through the Foundation’s employee giving program: One HudsonAlpha. Employees who donate to HudsonAlpha support research, education, and other areas of interest. We are proud to share that more than 75 percent of HudsonAlpha’s workforce made personal contributions to support the Institute’s mission of creating a healthier, more sustainable world.

Because of donors like you

The HudsonAlpha Foundation, a 501(c)(3) nonprofit organization, is the supporting entity for the HudsonAlpha Institute for Biotechnology. Tax-deductible contributions to the Foundation are for the sole purpose of advancing the mission of the HudsonAlpha Institute for Biotechnology. Tax identification #27-2320591

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