Zero Hunger (SDG 2), Good Health & Well-being (SDG 3)
The synthesis, characterization, antibacterial, and anticancer activity of new quinolone phenylhydrazone hybrids Palisha Aboo, Hogantharanni Govender * School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X54001, Durban, 4000, South Africa, * E-mail: govenderh@ukzn.ac.za Growing resistance of bacteria to available methods of treatment is a matter of great concern. In addition, the rapid growth in global cancer statistics1 has created a more vital need for research related to the identification of potent pharmacophores and their synthesis. One method of synthesis with great potential is hybridization. By ensuring the progress of medicinal research, the wellbeing and health of all individuals can be maintained. This is directly aligned with goal 3 of the United Nations Sustainable Development Goals. The quinolone and phenylhydrazone scaffolds have been identified as having antibacterial2, anticancer3 and antifungal activities. In this study, quinolone phenylhydrazone hybrids were synthesized as shown in Scheme 1. The compounds were structurally elucidated using NMR, IR, UV- Vis, and HRMS spectroscopy. Compound (E)-6-bromo-3-((2-phenylhydrazono)methyl)quinoline-2(1H)-one exhibited the best antibacterial activity against Methicillin-resistant Staphylococcus aureus (MIC = 22.82 µM). Compound, (E)-6-bromo-3-((2-(2-bromophenyl)hydrazono)methyl)quinoline-2(1H)-one was identified as a potential anticancer agent as it exhibited good activity against liver cancer (HepG2) cells (36.31 µg/100 µL). Key words: quinolone, phenylhydrazone, hybridization, antibacterial, anticancer
Scheme 1: Synthesis of phenylhydrazone hybrid compounds
References 1. H. Sung, J. Ferlay, R. L. Siegel, M. Laversanne, I.Soerjomataram, A. Jemal and F. Bray, CA: A Cancer Journal for Clinicians, 2021 , 71, 209-249. 2. A. Mirzaie, N. Peirovi, I. Akbarzadeh, M. Moghtaderi, F. Heidari, F. E. Yeganeh, H. Noorbazargan, S. Mirzazadeh and R. Bakhtiari, Bioorganic Chemistry, 2020 , 103, 104-231. 3. A. A. Aly, A. H. Mohamed and M. Ramadan, Journal of Molecular Structure, 2020 , 1207.
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