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Synthesis, characterization, and the antimicrobial effect of diiodothiocyanate (I2SCN-) on Escherichia coli and Enterococcus faecalis Nomaswazi Madonsela 1 , Tshephiso R. Papo 1 , Stefan Schmidt 2 and Bheki Xulu 1 1 School of Chemistry and Physics, University of KwaZulu-Natal, Private Bag X01, Scottsville, Pietermaritzburg, 3209, South Africa. 2 Microbiology, School of Life Sciences, University of KwaZulu-Natal, Scottsville, Pietermaritzburg 3201, South Africa E-mail: papot@ukzn.ac.za Herein, we describe the stability of interpseudohalogen diiodothiocyanate (I2SCN-) in acetonitrile. The formation of I2SCN- was confirmed by 13C NMR spectroscopy, ESI-MS spectrometry, UV-visible spectrophotometry, and the stopped-flow technique. The biological activities of I2SCN- against strains of Escherichia coli ( E coli ) and Enterococcus faecalis ( E faecalis ) bacteria were determined by zone of inhibition plate tests and traditional optical density (OD) measurements. Reaction mixtures of I2 and SCN- at various ratios showed inhibition against both Gram-positive ( E faecalis ) and Gram-negative ( E coli ) strains of bacteria. The results indicate that I2SCN- is more effective against E coli than E faecalis due to differences in the structural features of the two bacteria. Key words: antibacterial, diiodothiocyanate, E. coli, E faecalis
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