Scientific Evidence
Angiogenic Action An in vivo study showed that blue®m Oral Gel has an angiogenic action (stimulates the formation of new blood vessels) and stimulates the formation of collagen fibers, favoring better and faster healing (Deliberador TM, Macalossi JMS, Tenorio C, Dall´Agnol GS, Boia MF, Zielak JC. Oxygen-releasing agent promotes healing of skin wounds in rats. Accepted for publication in the Journal of Wound Care.) Bactericidal Action An in vitro study showed that the blue®m Oral Gel has an effect similar to that of chlorhexidine on the microbial effect on the formation of the biofilm of anaerobic bacteria in periodontal and peri-implant diseases (Shibli JA, Rocha TF, Coelho F, de Oliveira Capote TS, Saska S, Melo MA, Pingueiro JMS, de Faveri M, Bueno-Silva B. Metabolic activity of hydro- carbon-oxo-borate on a multispecies subgingival periodontal biofilm: a short communication. Clin Oral Investig. 2021 Oct;25(10):5945- 5953. doi: 10.1007/s00784-021-03900-0.)
Toxicity Test
Oral Lesions Professor Anna Turkina (Russia) demonstrated the significant improvement and healing in many cases with ulcerative form of Lichen planus after treating them with the use of topical corticosteroids in adjunction with blue®m oxygen therapy [11]. In addition, postoperative pain and the presence of inflammation are common symptoms after oral surgeries. The results of Professor Tatiana Deliberador (Brazil) and co-workers prove the promising effect of blue®m oxygen therapy to reduce any harmful effect on oral tissues, especially during the postsurgical healing phase [12,13]. In cases of large cystic lesions in mandible, blue®m oxygen therapy favors the healing and improving the success of the cases [14]. All products in the blue®m range (Toothpaste, Mouthwash, Aligner Foam, Oxygen Fluid and Oral Gel) were evaluated for toxicity using in vitro assays with spheroids and Epskin® equivalent reconstituted skin (3D). The results showed that the tested products are not toxic in the experimental model used (FIGURE 1) (Source: Research of the in vitro toxicity evaluation of blue®m oral hygiene products, carried out by professors Marceli Leano da Silva/ PPGBiotec Inmetro and Jose Mauro Granjeiro.
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