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Clinical and Scientific Summary The Science of WaterWipes®

Sensitive

Sensitive

WaterWipes® are the world’s purest wipes for sensitive skin WaterWipes® was created by our founder, Edward McCloskey, after his newborn daughter developed a diaper rash on her sensitive skin. After an extensive search, he couldn’t find a baby wipe that didn’t contain numerous ingredients, so he decided to make his own. Many years later, after a lot of hard work, testing, and scientific research, WaterWipes® was born. Pure and gentle for the most delicate skin, but with the convenience of a baby wipe, WaterWipes® are purer than cotton wool and water. Healthcare professionals in 50 countries around the world are discovering the benefits of our gentle and effective WaterWipes® for their patients (babies, children, adults, and seniors) with sensitive skin. WaterWipes® are available in all major retailers and online. Through scientific studies, publications, and expertise, WaterWipes® have been shown to be the world's purest wipes for sensitive skin.

WaterWipes® cleans and is gentle on sensitive skin Did you know that 71% of people identify as having sensitive skin*? 96% of Dermatologists agree that WaterWipes® is the #1 wipe choice for sensitive skin**

Sensitive Skin Cycle

The Itch / Scratch Cycle

Trigger generates itching

Skin feels itchy

Scratch

Skin scratched

Allergens, Irritants, Bacteria

Moisture Loss Inflammation

Skin barrier damage Penetration of irritants and allergens Irritation causes more itching

Rash Flakiness

Inflammation

Skin surface damage

Irritants penetrate skin

Tips when choosing skin wipes for those with sensitive skin: • Fewer ingredients may be better than more ingredients. • Choose products that do not leave residue on the skin. • Choose products with 0% alcohol and 0% perfume. • Be mindful of the ingredients list.

Eczema Skin Sensitive Skin

Healthy Skin

*The State of Skin Sensitivity Report, Aveeno, 2022 **Source: 272 Dermatologists at AAD, USA, 2024

Sensitive

3-in–1

Suitable for cleaning eczema-prone and sensitive skin Effective cleaning helped reduce sensitive skin indicators, including dryness, redness, roughness, and flakiness.

Cleans, Cares and Protects

Investigator Efficacy

2.50

2.33

2.33

2.33

2.33

2.00

1.50

1.67

1.67

®

Cares • pH suitable

Cleans • low surface

WORLD’S PUREST WIPES FOR SENSITIVE SKIN* 3 1 s IN

1.12

1.26

1.26

1.26

1.12

1.00

• minimal ingredients • microbiome friendly

tension for a deeper more effective clean • removing dirt you can and can’t see

1.00

0.50

1 2 3 4 5 6 7

0.00

Tactile roughness

Visual roughness

Dryness

Flakiness

Redness

Overall

Baseline Week 2

3 IN 1

Draelos Z, Sommerville J, Gilligan E. The tolerability of a Novel Wipe on Eczematous and Eczema Prone Baby Skin. [Manuscript submitted for consideration December 2024]

Protect • 99.9% water • 0% alcohol & perfume • no residue of surfactants & emulsifiers • accreditations Helps

….world’s purest wipes for sensitive skin

Cleans

Cleans

A clean you can trust

WaterWipes® 7 Stage water purification means our wipes:

WaterWipes® cleans 100% of the dirt applied to the skin

120

100

provide a deep and more effective clean and leave no residue

100% Removal

80

60

Skin cleaned with tap water

Skin cleaned with WaterWipes®

40

20

0

Pre-wipe

Feclone TM applied to skin

Post-wipe

7 stage purification

****

200,00

WaterWipes® cleaning efficiency and removal efficiency of E.coli from the skin was 99.9%.

150,00

100,00

50,00 400 200 0

Tap water alone cannot reach dirt sitting deeper within the skin's pores and crevices, meaning some is left behind.

WaterWipes® unique 7 stage water purification technology enables our formulation to reach the dirt deep within the skin, without the need for added surfactants.

1

WATER 99 .9%

7 stage water purification

A deeper & more effective clean*

To help care for & protect sensitive skin

**** p < 0.0001

*versus cotton wool & water

Arnold M, Wisdom S, Holohan K, et al. An alternative approach to validate the cleaning efficiency of a skin cleansing wipe. Cosmetics. 2024;11(5):172.

Cares

Cares

WaterWipes® has a pH in the neutral range, similar to that of blood or water. The pH of WaterWipes® is different from the pH of many other baby wipes. WaterWipes® formulation has a pH in the neutral range whilst many other baby wipes have a pH in the acidic range. For individuals with sensitive skin it may be preferable to cleanse the skin with a wipe in the pH neutral range, that gently cleanses and soothes the skin.

Microbiome friendly accredited

WaterWipes® is the only wipe brand to date to have received the microbiome-friendly certification, indicating that a product made from ultra-pure water and minimal ingredients respects the balance of the skin microbiome. A healthy skin microbiome is key for an intact skin barrier.

Protects

Cares

Suitable for older skin Skin becomes thinner as we age and increasingly fragile. Using detergent-free wipes, such as WaterWipes® sensitive + body & intimate, to cleanse skin has been shown to be effective in older adults.

WaterWipes® are unique and superior

14 day user study in the USA with Adult Wipes

Incontinence-related irritation in aged skin can cause mechanical injury and increased susceptibility to infection. Cleansing wipes for ageing skin should be formulated to help protect the skin barrier, with mild formulations that gently cleanse and support the acid mantle, preventing an increase in trans-epidermal water loss (TEWL) and potential irritation. Excessive used of harsh surfactants

% of respondents who reported dry skin

54%

Manifests as: • Redness • Dryness, itching • Discomfort • Sensorial irritation

Surfactant Micelles

Surfactant Monomers

WATER 99 .9%

5%

Removes important skin components

Disrupts the skin structure

Before After

26%

• No residue of surfactants and emulsifiers • Non foaming • 0% alcohol & 0% perfume • Proven to soothe and calm skin by up to 26% *

Sommerville J, Gilligan E, Schols J. Detergent free wipes for geriatric care. Presented at: 20th EuGMS Congress; September 18-20, 2024; Valencia, Spain.

*Instrumental test, 10 participants, July 2023

Protects

Most widely accredited wipe brand in the world

External Affairs: April 2025

WaterWipes® are a cosmetic product and do not treat, cure or prevent any medical conditions

www.waterwipes.com

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