Ketamine and depression
integrity of these indispensable connections. ‘ Some animal studies have found that infusing BDNF into the brain reverses depression-like symptoms in three days ’ , 5 Dr. Krystal states. As a catalyst, ketamine works to promote BDNF production. By amplifying BDNF production and promoting the formation of new connections, ketamine takes on the role of revitalizing these neural pathways. When these pathways are strengthened, the brain’s capacity to govern mood undergoes a renewal, offering a way to escape from the grip of depression.
Ketamine vs traditional antidepressants
Ketamine and traditional antidepressants present divergent methods of depression therapy. Traditional antidepressants, such as SSRIs and SNRIs, primarily aim to modulate the accessibility of neurotransmitters like serotonin and norepinephrine in the brain. However, these interventions exhibit a gradual impact, often demanding extended periods of weeks or even months for noticeable results; their mechanism revolves around the recalibration of the chemical equilibrium of these neurotransmitters. Furthermore, according to a review of 17 previous studies, Joanna Moncrieff and her colleagues at UCL found out that there is no supporting evidence that a low serotonin level directly leads to depression. ‘ The implication of our paper is that we do not know what [SSRI] antidepressants are doing, ’ 6 Moncrieff states. Conversely, for ketamine, what sets it apart is its quick-acting quality. Within a matter of hours or days, a noticeable improvement in depressive symptoms might be experienced. The secret hinges on ketamine’s unique interaction with the glutamate system and NMDA receptors, triggering swift changes in neural interactions. In Dr. Krystal’s experiment of testing ketamine as an antidepressant, the results were as follows: ‘T rials in people showed that an infusion of ketamine acts quickly to reduce depression symptoms. Most people then need repeat treatments every one or two weeks .’ 7 In addition, unlike traditional antidepressants, which always demand a process of trial and error to identify the right medication and dosage, ketamine demonstrates potential effectiveness across a broader range of individuals.
Traditional antidepressants serve as progressive regulators of neurotransmitter levels, while ketamine’s exceptional interaction with neural pathways provides rapid relief. Ongoing investigation of both methods offers tailored solutions based on individuals’ specific needs and res ponses.
5 Szalavitz, M. Tackling Depression with Ketamine . https://www.newscientist.com/article/mg19325876-600- tackling-depression-with-ketamine/ Consulted: 16/8/23 6 Wild, S. No link between depression and serotonin, finds major analysis. https://www.newscientist.com/article/2328700-no-link-between-depression-and-serotonin-finds-major- analysis/ Consulted: 18/8/23 7 Wilson, C. Fresh ideas about the causes of depression are bringing new treatments. https://www.newscientist.com/article/mg25734220-100-fresh-ideas-about-the-causes-of-depression-are- bringing-new-treatments/ Consulted: 18/8/23
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