Cold Therapy Clinical Research Overview

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Knobloch 2006b

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Knobloch K, Kraemer R, Lichtenberg A, Jagodzinski M, Gosling T, Richter M, Krettek C. Microcirculation of the ankle after Cryo/Cuff application in healthy volunteers. Int J Sports Med. 2006 Mar;27(3):250-5.

Design: Prospective experimental study. Subjects: 21 healthy volunteers Methods: The Aircast Cryo/Cuff ankle device was applied with continuous assessment of parameters of ankle microcirculation, Outcomes included: Tissue oxygen saturation, relative postcapillary venous filling pressures, and microcirculatory blood flow at 2- and 8-mm tissue depths Results: • Superficial tissue oxygen saturation immediately dropped with 52% within the first 2 minutes after Cryo/Cuff activation with a consecutive slow decrease of 32% after 30 minutes. • Deep tissue oxygen saturation did not change within 30 min of Cryo/Cuff application.

Key message: The Cryo/Cuff device has significant effects on ankle microcirculation in healthy volunteers with no complications - effects that are desirable in the treatment of acute soft-tissue injuries.

• Superficial postcapillary venous filling pressures showed an immediate and sustained decrease with 39% after Cryo/Cuff application within 4 minutes. • Deep postcapillary venous filling pressures dropped within the first 4 minutes of Cryo/Cuff application with 20%. • Superficial microcirculatory blood flow decreased significantly (-69%) • Deep microcirculatory blood flow at 8mm tissue depth significantly decreased (- 47%) over the 30 minutes. • Non of the patients had any skin burns or nerve palsies, such as paresthesias or paresis, caused by the Cryo/Cuff.

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