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Guillot 2014
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Guillot X, Tordi N, Mourot L, Demougeot C, Dugué B, Prati C, Wendling D. Cryotherapy in inflammatory rheumatic diseases: a systematic review. Expert Rev Clin Immunol. 2014 Feb;10(2):281-94.
Design: Systematic Review
Methods: Studies including non-operated and non-infected arthritic patients treated with local cryotherapy or whole-body cryotherapy we selected. 6 studies including 257 rheumatoid arthritis (RA) patients were included for pooling the data. Outcomes included: Pain (VAS), DAS-28 score (disease activity), molecular pathways.
Key message: Cryotherapy reduces pain, disease activity and inflammation in Rheumatoid Arthritis and should be included in treatment protocols as adjunct therapy.
Results:
• Significant decreases in pain visual analogic scale (mm) and 28-joint disease activity score after chronic cryotherapy in RA patients. • For molecular pathways, local cryotherapy induces an intrajoint temperature decrease, which might downregulate several mediators involved in joint inflammation and destruction (cytokines, cartilage- degrading enzymes, proangiogenic factors), but studies in RA are rare.
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