Multi-million dollar grant for lung cancer study
Leading Royal North Shore Hospital (RNSH) clinician researcher Professor Nick Pavlakis and Professor Ben Solomon secured a $14.7 million grant for a clinical trial exploring the use of a liquid biopsy to inform treatment for lung cancer.
Professor Nick Pavlakis
The condition is the leading cause of cancer death in Australia and worldwide, claiming an estimated 9,000 lives in Australia each year. The pioneering study will place Australia at the forefront of global precision medicine by using liquid biopsies to revolutionise personalised lung cancer treatment. The trial involves some of the country’s most respected lung cancer clinicians and researchers, and will be available to patients across Australia. Professor Pavlakis said the large-scale clinical trial will involve more than 500 people with advanced non-small cell lung cancer, offering them access to the exciting new treatment. “Over the last decade, treatment for non-small cell lung cancer has been transformed by the discovery of several genomic mutations that drive tumour growth.”
“This has led to effective new therapies which specifically target the mutation, moving away from general chemotherapy to daily tablets at home with tolerable side effects. “Many patients have survived up to 10 years living with their lung cancer, but in most cases, the cancer inevitably develops resistance to the targeted therapies.”
in response to treatment,” said Professor Pavlakis. “This will inform what treatments will be the best for a given patient. “The approach represents a unique opportunity to refine personalised medicine for lung cancer, not just at the time of diagnosis, but throughout treatment. “It is a major step forward and a testament to the many people involved in progressing our work to this point. “We anticipate it will lead to improved survival and quality of life, and may provide supporting evidence for broader liquid biopsy application to transform the treatment for other cancers as well.” The NORTH STAR VNP will be participating in the transformative study, utilising
To date, clinicians have relied on invasive tissue
biopsies to inform treatment options, but this clinical trial is investigating the use of a liquid biopsy (circulating
tumour DNA) to guide a personalised approach
throughout a patient’s journey. It could change the way lung cancer is treated and provide a model for other cancers as well. “A simple blood test will be less invasive, provide quicker results and will enable more frequent feedback on what genomic changes have occurred
the telehealth platform to provide access to patients across its network.
31 NSLHD 2025 Year in Review
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