Intraocular application of gold nanodisks optically tuned for optical coherence tomography Jeong Hun Kim 1, 2 and Tae Geol Lee 3 1 Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Biomedical Research Institute, Seoul National University Hospital, Republic of Korea, 2 Department of Biomedical Sciences & Ophthalmology, Seoul National University Graduate School, Republic of Korea, 3 Center for Nano-Bio Measurement, World Class Laboratory, Korea Research Institute of Standards and Science, Republic of Korea Bare gold nanospheres have been shown to have anti-angiogenic effects but are optically unfavorable because their resonant wavelengthlies in the visible spectrum. Here, we design gold nanodisks with a higher scattering capability than gold nanorods and with a resonantwavelength at near-infrared region – the area where the source of light utilized by optical coherence tomography (OCT) lies. (1) With a physical synthesis system, we then fabricate 160-nm-sized gold nanodisks exhibiting resonant wavelength at 830 nm. The synthesized nanoparticleswere successfully visualized in in vivo OCT at concentrations as low as 1 pM.Finally, we demonstrate thatintravitreally injected gold nanodisks are cleared from the vitreous within 2 weeks without toxicity. References 1. Nanomedicine: NBM 2017;13:1901-1911
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