Development of eco-friendly mixtures for 3D printing to produce biocompatible products with antimicrobial properties Ana Catarina Cardoso de Sousa 1,2 , Rafaela G. Cabral 2 , Inês Amaral 1 , Ivo Manuel Bragança 3,4 , Cris H. J. Franco 2 , Tiago A. Fernandes 2 , Alexander M. Kirillov 2 1 Departamento de Engenharia Química, Instituto Superior de Engenharia de Lisboa, Instituto Politécnico de Lisboa, R. Conselheiro Emídio Navarro, 1, 1959 007 Lisboa, Portugal. 2 Centro de Química Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049 001 Lisboa, Portugal. 3 iDMEC - Instituto de Engenharia Mecânica, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049 001 Lisboa, Portugal. 4 Centro de Investigação em Modelação e Optimização de Sistemas Multifuncionais, Instituto Superior de Engenharia de Lisboa, R. Conselheiro Emídio Navarro, 1, 1959 007 Lisboa, Portugal. Three-dimensional (3D) printing represents a promising technique to fabricate various objects with functional properties [1, 2]. The development of new liquid natural-based resins as matrices for 3D printing is currently an expanding area of research. These matrices and derived materials are generally biocompatible and sourced from renewable natural feedstock, making them very appealing in terms of economic and environmental needs. The biological properties of resins and the obtained 3D printed materials can be boosted by adding components with antimicrobial properties. These components may incorporate biocidal metals with a particularly recognized antimicrobial function [3-5]. Examples of such compounds include Ag, Cu, or Zn-based coordination polymers (bioCPs) that can combine the biocidal metal center with bioactive ligands and give rise to potent antimicrobial agents [6] . The present study reports our research results on the use of soybean oil derived resin, as a candidate to produce biopolymer films and 3D printed objects, doped with new bioactive silver(I), copper(II), and zinc(II) coordination polymers (bioCPs). The purpose is to take advantage of the non-toxicity of the biopolymer matrix and introduce the antiseptic properties of bioCPs, thus developing hybrid materials with improved chemical and antimicrobial characteristics. References 1. Liu, J., Sun, L., Xu, W., Wang, Q., Yu, S. &; Sun, J. (2019). Current advances and future perspectives of 3D printing natural- derived biopolymers. Carbohydrate Polymers, 207, 297–316. 2. Elkasabgy, N. A., Mahmoud, A. A. &; Maged, A. (2020). 3D printing: An appealing route for customized drug delivery systems. International Journal of Pharmaceutics, 588, 119732 -119747. 3. Abram, S.L. &; Fromm, K.M. (2020). Handling (Nano)Silver as Antimicrobial Agent: Therapeutic Window, Dissolution Dynamics, Detection Methods and Molecular Interactions, Chemistry—A European Journal, 26, 10948. 4. Salah, I., Parkin, I.P. &; Allan, E. (2021). Copper as an antimicrobial agent: recent advances, RSC Adv., 11, 18179-18186. 5. Pasquet, J., Chevalier, Y., Pelletier, J., Couval, E., Bouvier, D. &; Bolzinger, M.-A. (2014). The contribution of zinc ions to the antimicrobial activity of zinc oxide, Colloids and Surfaces A: Physicochem. Eng. Aspects. 457, 263–274. 6. Fernandes, T.A., Costa, I.F.M., Jorge, P., Sousa, A.C., André, A., Cerca, N. &; Kirillov, A.M. (2021). Biopolymer Films Doped with Silver(I) Coordination Polymers against Bacterial Biofilms. ACS Appl. Mater. Interfaces 2021, 13, 12836–12844.
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