Wearable sensor for the non-invasive detection of D-glucose with electroactive molecularly imprinted polymers (eMIPs) Saweta Garg, Shayan Seyedin and Marloes Peeters School of Engineering, Merz Court, Claremont Road, Newcastle University, Newcastle Upon Tyne-NE1 7RU, UK Continuous monitoring of glucose levels is crucial to managing diabetes, especially in pregnant and geriatric patients. The conventional method is to measure glucose levels with a finger prick test, which is invasive and can be uncomfortable [1-3] . In this work, electroactive molecularly imprinted polymers (eMIPs) based wearable devices was proposed for the continuous monitoring of glucose. This sensor offers an alternative means to existing methods with superior chemical stability, specificity, economic, and easy fabrication. eMIPs selective for glucose was fabricated using Pyrrole as monomer [4] . eMIPs have been characterized by UV-visible, Dynamic Light Scattering (DLS), electrophoretic and Transmission Electron Microscopy (TEM). Further, Cyclic Voltammetry was employed for detection of glucose using screen printed electrode drop casted with eMIPs and showed linear response within the concentration range of 1mM to 10mM. Moreover, eMIPs have not shown binding with structurally similar interferents such as fructose, galactose indicating towards the selectivity. Additionally, no observed changes in the current/potential in CV to non-imprinted MIPs (NIPs) with glucose further proved the specificity. In the next steps, these MIPs will be embedded with electroactive fibres such as PEDOT:PSS and MXenes to tune the sensitivity and stability of the prepared sensor and will be used in wearable sensor
technology. References
1. Azhar et al ., Journal of Pharmacy & Bioallied Sciences, 2020, 12, 102. 2. Ricci et al., Biosensors and Bioelectronics, 2005, 20, 1993-2000. 3. Heinemann et al., Journal of diabetes science and technology, 2008, 2, 919-21. 4. Crapnell et al., Analytical Chemistry, 2021, 93, 13235-41.
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