Synthesis, characterisation and evaluation of polymer modified iron oxide nanoparticle matrix for biological and bio-medical applications Rakesh Kumar 1,2,4 , Abdo Amir 3 , Atif Shahzad 2,4 , William Wyns 2,3,4 , Pau Farras 1,3 1 School of Chemistry, University of Galway. Galway, Ireland, 2 School of Medicine, University of Galway. Galway, Ireland, 3. CÚRAM, SFI Research Centre for Medical Devices, University of Galway, Ireland, 4. Smart sensor lab, University of Galway, Galway Recently, Magnetic materials have been explored for their potent flexible properties that can be easily engineered for various biological application. For example, iron oxide nanoparticles (IONPs) materials are the excellent emerging candidate due to their magnetic properties and super-magnetism that led to high biocompatibility, ease of synthesis and modification or functionalisation of their surface with biomolecules or other chemical molecules. Several methods have been used to form organic or inorganic layer that encapsulated in a polymer matrix on iron oxide core of IONPs [1-4] . Herein we described the potential of one pot synthesis of polymer coated iron oxide nanoparticles for the controlled drug delivery and biological application. The polymer coated iron oxide nanoparticle has been successfully synthesised and characterised by Fourier transform infrared spectroscopy (FTIR), Transmission electron microscopy (TEM), zeta potential, Thermogravimetric analysis (TGA) which demonstrated the polymer layer on the nanoparticle surface. Significant change in the nanoparticle size and morphology were observed for bare and polymer coated magnetic nanoparticles. Furthermore, polymer modified nanoparticle were investigated as a potential drug carrier matrix. The cancer drug was grafted to the polymer modified nanoparticle matrix via physical adsorption and covalent attachment. In vitro release profile showed the controlled release of drug up to 140 h. Moreover, the drug loaded polymer nanoparticles were tested on MDA-MB-231 cells which revealed the further decrease in the cell viability and metabolic activities of the cells. Overall, covalently attached drug polymer nanoparticle matrix exhibited more cytotoxicity profile with better cellular uptake. References 1. H. V. Tran et al., "Multifunctional Iron Oxide Magnetic Nanoparticles for Biomedical Applications: A Review," (in eng), Materials (Basel), vol. 15, no. 2, Jan 10 2022, doi: 10.3390/ma15020503. 2. S. Liu, B. Yu, S. Wang, Y. Shen, and H. Cong, "Preparation, surface functionalization and application of Fe(3)O(4) magnetic nanoparticles," (in eng), Adv Colloid Interface Sci, vol. 281, p. 102165, Jul 2020, doi: 10.1016/j.cis.2020.102165. 3. W. Wu, Z. Wu, T. Yu, C. Jiang, and W. S. Kim, "Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications," (in eng), Sci Technol Adv Mater, vol. 16, no. 2, p. 023501, Apr 2015, doi: 10.1088/1468-6996/16/2/023501. 4. Z. Hou, Y. Liu, J. Xu, and J. Zhu, "Surface engineering of magnetic iron oxide nanoparticles by polymer grafting: synthesis progress and biomedical applications," (in eng), Nanoscale, vol. 12, no. 28, pp. 14957-14975, Jul 23 2020, doi: 10.1039/ d0nr03346d.
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