Screening and reaction monitoring with a high-throughput potentiostat
Lane Baker 1 , Benjamin H. R. Gerroll 2 , Krista Kulesa 2 1 Texas A&M University, USA, 2 Indiana University, USA
Discovery and analysis with array-based measurements is an important approach in modern measurement science. For instance, arrays of biomolecules, such as nucleic acids or peptides, have proven key tools in genomics, proteomics, molecular biology and bioinformatics. Likewise, arrays of materials, such as ligands, nanoparticles, and metallic compositions, have found utility in the discovery of new catalysts.Signal detection/ transduction in array-based measurements has been dominated by optical methods, where fluorescence is especially adept. Array analysis by mass spectrometry has also contributed significant discoveries. Electrochemical arrays have also found application, however, to a lesser extent Electrochemical arrays often consist of a single type of electrode arrayed in series to take advantage of mass transport effects to the array. Parallel approaches where each electrode in an array can be operated at the same time with independent control of potential and signal collection have been much less common, owing largely to difficulties in instrumentation. To truly enable high-throughput electrochemistry, we believe full control over each electrode in an array should be enabled. Applications of a parallel high-throughput electrochemical array could have broad impact in diverse areas of science, including electroorganic synthesis,electrocatalyst discovery, fundamental nanoscience, and bioelectrochemical assays. Here, we describe an electrochemical platform, colloquially referred to as “Legion” toward the goal of developing high-throughput routes to parallel electrochemical arrays. General instrumental construction, performance benchmarks, and preliminary application in the areas of electrosynthesis are described.
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© The Author(s), 2023
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