Culturing Challenges and Genetic Stability
Pluripotent Stem Cells
Maintaining pluripotent cells is a delicate process:
Environmental Sensitivity: They require a very exact environment. Any small change in temperature, nutrient mix, or other conditions can cause these cells to differentiate unexpectedly or become stressed.
Mutation Risks: The longer these cells are cultured in the lab, the greater the chance for them to acquire genetic mutations. This instability not only reduces their effectiveness but also increases the risk of tumor formation.
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Multipotent Stem Cells
Multipotent cells are more forgiving:
Lower Mutation Risk: Their slower growth rate means there's less chance for errors during cell division, keeping their genetic makeup more stable over time.
Robustness: They can thrive under less stringent conditions. This reduces the chance of culture-induced stress and helps maintain their safety profile.
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