What Does the Scientific Research Conclude About Pluripotent Stem Cells?
Ben-David & Benvenisty (2011) Study:
This review discusses how both embryonic and induced pluripotent stem cells harbor the potential to form teratomas if residual undifferentiated cells remain after transplantation. The authors highlight that even minimal contamination with undifferentiated cells can lead to tumor formation, underlining the need for rigorous differentiation and quality control protocols.
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This study examines the hurdles in clinical application of induced pluripotent stem cells, with a focus on their tumorigenic potential. The researchers discuss how prolonged culture and the inherent instability of pluripotent cells can contribute to mutation accumulation, which may further increase the risk of tumorigenicity. Their findings stress the importance of developing methods to completely eliminate undifferentiated cells before clinical use. Lee et al. (2013) Study: View Study
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