SBMS Newsletter Issue 02

Dr. Rio Sugimura PhD (Stowers Institute for Medical Research), MD, BS (Osaka U) (will join our school as Assistant Professor on 21 Dec 2020)

“Born in Japan, I have been scientically raised in the USA. After my scientic journey through stem cell biology and hematology, I am more than elated to lead my lab at HKU. My research program focuses on fundamental questions in cancer immunotherapy and its application. Excited to serve the HKU community through collaborations on blood-generating organoids, iPS cells, and the generation of innate immune cells from patients. For anyone who wants to join my lab, feel free to contact me rios@hku.hk.”

Dr. Mu He PhD, BS (Cornell U) (will join our school as Assistant Professor on 1 Feb 2021)

“After spending almost two decades in New York and the SF Bay Area, I look forward to establishing my research group at HKU. By leveraging the power of stem cell biology and single-cell technologies, we aim to understand how the respiratory system develops, repairs, and regenerates. Through proactive collaboration between research and medicine, our ultimate goal is to translate basic biomedical discovery into eective therapies for respiratory diseases.”

9 December 2020 Sassoon Road Alumni Workshop (via Zoom)

Prof. Chenli Liu 2011 PhD Graduate

Prof. Lin-yu Lu 2007 PhD Graduate

Dr. Bo Gao 2005 PhD Graduate

Dr. Justin Leung 2007 PhD Graduate

Dr. Elaine Wong 2006 PhD Graduate

Prof. Baohua Liu 2007 PhD Graduate

Dr. Kui Ming Chan 2008 PhD Graduate

The Workshop represents an exciting initiative for our school members to reunite with our alumni from across the globe, and to learn from them their paths to pursuing biomedical research. Apart from appreciating the science it will also be an excellent opportunity for us to build and strengthen the connections with which our students will surely nd helpful as they continue to explore careers in biomedical sciences.

Publications Highlights 1.

Lok-Yin Roy Wong , Zi-Wei Ye, Pak-Yin Lui , Xuyang Zheng , Shuofeng Yuan, Lin Zhu, Sin-Yee Fung , Kit-San Yuen , Kam-Leung Siu , Man-Lung Yeung, Zongwei Cai, Patrick Chiu-Yat Woo, Kwok-Yung Yuen, Chi-Ping Chan , Dong-Yan Jin (2020) Middle East Respiratory Syndrome Coronavirus ORF8b Accessory Protein Suppresses Type I IFN Expression by Impeding HSP70-Dependent Activation of IRF3 Kinase IKKε. Journal of immunology 2020, ji1901489. doi:10.4049/jimmunol. 1901489. Published 3 Aug 2020. 2. Bao-Zhong Zhang , Hin Chu, Shuo Han , Huiping Shuai, Jian Deng , Ye-Fan Hu , Hua-Rui Gong , Andrew Chak-Yiu Lee, Zijiao Zou, Thomas Yau, Wutian Wu , Ivan Fan-Ngai Hung, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Jian-Dong Huang (2020) SARS-CoV-2 infects human neural progenitor cells and brain organoids. Cell research 2020, 1-4. doi: 10.1038/s41422-020-0390-x. Published 4 Aug 2020. 3. Sharafuddin Khairuddin , Luca Aquili, Boon Chin Heng, Tze Lok Cecil Hoo, Kah Hui Wong, Lee Wei Lim (2020) Dysregulation of the orexinergic system: A potential neuropeptide target in depression. Neuroscience and biobehavioral reviews 2020, 118:384-396. doi: 10.1016/j.neubiorev.2020.07.040. Published 5 Aug 2020. 4. Sai-Kam Li , Hoi-Ching Tang , Manton Man-Hon Leung , Wenjun Zou , Wing-Lim Chan , Yuan Zhou , Irene Oi-Lin Ng, Yick Pang Ching (2020) Centrosomal protein TAX1BP2 inhibits centrosome-microtubules aberrations induced by hepatitis B virus X oncoprotein. Cancer letters 2020, S0304-3835(20)30417-1. doi: 10.1016/j.canlet.2020.08.005. Published 19 Aug 2020. 5. Simon Chi-Chin Shiu , Yusuke Sakai, Julian A Tanner # , Jonathan G Heddle # (2020) FRET-Mediated Observation of Protein-Triggered Conformational Changes in DNA Nanostructures. Methods in molecular biology (Clifton, N.J.) 2020. doi: 10.1007/978-1-0716-0928-6_5. Published on 28 Aug 2020. # co-corresponding authors 6. Lei Han , Kenneth Lap-Kei Wu , Pui-Yi Kwan , Oscar Wing-Ho Chua , Daisy Kwok-Yan Shum , Ying-Shing Chan (2020) 5-HT 1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function. The Journal of Physiology 2020. doi: 10.1113/JP280610. Published 2 Oct 2020. 7. Shiny Shengzhen Guo , Tiany YK Au , Sarah Wynn , Attila Aszodi, Danny Chan , Reinhard Fässler, Kathryn SE Cheah (2020) β1 integrin regulates convergent extension in mouse notogenesis, ensures notochord integrity and the morphogenesis of vertebrae and intervertebral discs. Development (Cambridge, England) 2020. doi: 10.1242/dev.192724. Published 13 Oct 2020. 8. Sze P Tsui , Ho W Ip, Nicole Y Saw , Chunxiao Zhang, Arthur K Cheung, Nelson K Ng, Cheuk H Man, Stephen S Lam, Wing F Tang, Chi H Lin, Grace H Cheng, Chun H Au, Edmond S Ma, Tsun L Chan, Jason C So, Margaret H Ng, Kelvin C Cheng, Kit F Wong, Lai P Siu, Sze F Yip, Shek Y Lin, June S Lau, Tsan H Luk, Harold K Lee, Chi K Lau, Bonnie Kho, Joycelyn P Sim, Yok L Kwong, Suet Y Leung, Asif Javed # , Anskar Y Leung # (2020) Redening prognostication of de novo cytogenetically normal acute myeloid leukemia in young adults. Blood Cancer Journal 2020. doi: 10.1038/s41408-020-00373-4. Published 19 Oct 2020. # co-corresponding authors 9. Tiany YK Au , To-Kam Lam, Yan Peng, Sarah L Wynn , Kenneth M C Cheung, Kathryn SE Cheah # , Victor Y L Leung # . (2020) Transformation of resident notochord-descendent nucleus pulposus cells in mouse injury-induced brotic intervertebral discs. Aging Cell, e13254. doi: 10.1111/acel.13254. Published 21 Oct 2020. # co-corresponding authors 10. Krit Lee , Hei Ming Lai , Maja Hoejvang Soerensen , Edward Sai-Kam Hui, Victor Wan-San Ma, William Chi-Shing Cho, Yuen-Shan Ho, Raymond Chuen-Chung Chang (2020) Optimized tissue clearing minimizes distortion and destruction during tissue delipidation. Neuropathol Appl Neurobiol. doi: 10.1111/nan.12673. Published 26 Oct 2020. 11. S Chul Kwon , Harim Jang, Siyuan Shen, S Chan Baek, Kijun Kim, Jihye Yang, Jeesoo Kim, Jong-Seo Kim, Suman Wang, Yunyu Shi, Fudong Li, V Narry Kim (2020) ERH facilitates microRNA maturation through the interaction with the N-terminus of DGCR8. Nucleic Acids Res. doi: 10.1093/nar/gkaa827. Published 4 Nov 2020. 12. Noélia Che , Kai-Yu Ng , Tin-Lok Wong , Man Tong , Phillis WF Kau , Lok-Hei Chan , Terence K Lee, Michael SY Huen , Jing-Ping Yun, Stephanie Ma (2020) PRMT6 deciency induces autophagy in hostile microenvironments of hepatocellular carcinoma tumors by regulating BAG5-associated HSC70 stability. Cancer Lett. doi: 10.1016/j.canlet.2020.11.002. Published 11 Nov 2020.

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