New Equipment School Highlights
Large capacity centrifuge (Hitachi/ Himac CR7N) Refrigerated high capacity centrifuge with swinging bucket rotor for low speed centrifugation
High speed centrifuge (Hitachi/ Himac CR22N)
Bacterial shaking incubator (Labwit/ ZWYR2402)
Refrigerated high speed centrifuge with fixed angle rotors
Refrigerated bacterial shaking incubator
Location: L3-28, Lab Block Tech-in-charge: Mr. Anthony Tsang acctsang@hku.hk | 3917 9248
Location: L3-28, Lab Block Tech-in-charge: Mr. Anthony Tsang acctsang@hku.hk | 3917 9248
Location: L3-30, Lab Block Tech-in-charge: Ms. Sheila Tsang sltsang@hku.hk | 3917 9481
4D-Nucleofector (Lonza / Core +X+Yunits)
Whole cell patch-clamp system (Axon/ Multiclamp 700B, Digidata 1440A; Nikon/ Eclipse Ti)
For cell transfection
For measurement of electrical properties of whole-cell
Location: L4-18, Lab Block Tech-in-charge: Ms. Kary Xu karyxu@hku.hk | 3917 9268
Location: L4-03, Lab Block Tech-in-charge: Dr. Trista Kwan pykwanaa@hku.hk | 3917 9274
*Corresponding Authors | # Co-first Authors | School Members in Bold and Orange Font Publications Highlights
1. Fung SY, Siu KL, Lin H, Chan CP , Yeung ML, Jin DY* . SARS-CoV-2 NSP13 helicase suppresses interferon signaling by perturbing JAK1 phosphorylation of STAT1. Cell Biosci. 2022 Mar 22;12(1):36. 2. Cheng WY , Ho YS*, Chang RC* . Linking circadian rhythms to microbiome-gut-brain axis in aging-associated neurodegenerative diseases. Ageing Res Rev. 2022 Apr 8;78:101620. 3. Hu YF# , Hu JC#, Gong HR#, Danchin A, Sun R , Chu H, Hung IF, Yuen KY, To KK, Zhang BZ*, Yau T*, Huang JD* . Computation of antigenicity predicts SARS-CoV-2 vaccine breakthrough variants. Front Immunol. 2022 Mar 24;13:861050. 4. Ye ZW#, Ong CP# , Tang K#, Fan Y# , Luo C, Zhou R, Luo P, Cheng Y, Gray VS , Wang P, Chu H, Chan JF, To KK, Chen H, Chen Z, Yuen KY, Ling GS* , Yuan S*, Jin DY* . Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals. Cell Mol Immunol. 2022 Mar 29:1–14. 5. Chan KY, Kinghorn AB , Hollenstein M, Tanner JA* . Chemical modifications for a next generation of nucleic acid aptamers. Chembiochem. 2022 Apr 13. doi: 10.1002/cbic.202200006. 6. Swiatlowska P#, Sit B#, Feng Z# , Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu CH* , Iskratsch T*. Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. Sci Adv. 2022 Apr 15;8(15):eabm3471. 7. Jin W, He Y, Li T, Long F, Qin X, Yuan Y, Gao G, Shakhawat HM , Liu X, Jin G*, Zhou Z* . Rapid and robust derivation of mesenchymal stem cells from human pluripotent stem cells via temporal induction of neuralized ectoderm. Cell Biosci. 2022 Mar 15;12(1):31. 8. Thean DG#, Chu HY#, Fong JH, Chan BK, Zhou P, Kwok CC , Chan YM, Mak SY, Choi GC, Ho JW , Zheng Z, Wong AS* . Machine learning-coupled combinatorial mutagenesis enables resource-efficient engineering of CRISPR-Cas9 genome editor activities. Nat Commun. 2022 Apr 25;13(1):2219. 9. Du Z*, Tian L*, Jin DY* . Understanding the impact of rapid antigen tests on SARS-CoV-2 transmission in the fifth wave of COVID-19 in Hong Kong in early 2022. Emerg Microbes Infect. 2022 May 10:1-19. 10. Wang H#, Zheng C#, Lu W, He T, Fan J, Wang C , Jie Q, Chan D, Cheah KS*, Yang L* . Hedgehog signaling orchestrates cartilage-to-bone transition independently of Smoothened. Matrix Biol. 2022 Apr 23:S0945-053X(22)00058-0. 11. Ti SC* . Reconstituting microtubules: A decades-long effort from building block identification to the generation of recombinant α / β -tubulin. Front Cell Dev Biol. 2022 Apr 28;10:861648. 12. Zhang BZ#, Shuai H#, Gong HR# , Hu JC#, Yan B#, Yuen TT, Hu YF , Yoon C, Wang XL , Hou Y, Lin X , Huang X, Li R, Au-Yeung YM , Li W, Hu B, Chai Y, Yue M , Cai JP, Ling GS , Hung IF, Yuen KY, Chan JF*, Huang JD* , Chu H*. Bacillus Calmette-Guérin-induced trained immunity protects against SARS-CoV-2 challenge in K18-hACE2 mice. JCI Insight. 2022 Apr 21:e157393. 13. Hou R, Huang Y* . Genomic sequences and RNA binding proteins predict RNA splicing efficiency in various single-cell contexts. Bioinformatics. 2022 May 13:btac321. 14. Li H, Barbour JA, Zhu X, Wong JW* . Gene expression is a poor predictor of steady-state metabolite abundance in cancer cells. FASEB J. 2022 May;36(5):e22296. 15. Cao H, Sugimura R* . Off-the-shelf chimeric antigen receptor immune cells from human pluripotent stem cells. Cancer Treat Res. 2022;183:255-274. 16. Gao S, Sugimura R* . The single-cell level perspective of the tumor microenvironment and its remodeling by CAR-T Cells. Cancer Treat Res. 2022;183:275-285. 17. Sugimura R*, Chao Y . Deciphering innate immune cell-tumor microenvironment crosstalk at a single-cell level. Front Cell Dev Biol. 2022 May 13;10: 803947. 18. Sugimura R*, Wang CY . The role of innate lymphoid cells in cancer development and immunotherapy. Front Cell Dev Biol. 2022 Apr 26;10:803563. 19. Hou Y#, Jing J#, Luo Y, Xu F, Xie W, Ma L, Xia X, Wei Q, Lin Y*, Li KH*, Chu Z* . A versatile, incubator-compatible, monolithic GaN photonic chipscope for label-free monitoring of live cell activities. Adv Sci. 2022 Jun;9(17):e2200910. doi: 10.1002/advs.202200910. 20. Yu WS, Tse AC, Guan L, Chiu JL, Tan SZ, Khairuddin S , Agadagba SK, Lo ACY, Fung ML, Chan YS , Chan LLH*, Lim LW* . Antidepressant-like effects of transcorneal electrical stimulation in rat models. Brain Stimul. 2022 May 28;15(3):843-856. 21. Huang C#, Chu JM#, Liu Y, Kwong VS, Chang RC* , Wong GT*. Sevoflurane induces neurotoxicity in the animal model with Alzheimer's disease neuropathology via modulating glutamate transporter and neuronal apoptosis. Int J Mol Sci. 2022 Jun 2;23(11):6250. 22. Yu J#, Kuwentrai C#, Gong HR, Li R, Zhang BZ, Lin X, Wang X, Huang JD* , Xu C*. Intradermal delivery of mRNA using cryomicroneedles. Acta Biomater. 2022 Jun 10:S1742-7061(22)00353-1.
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