Congratulations External Grant
Project Title: Project Coordinator: Amount Awarded: Award Date: Mechanism of inflammasome activation by SARS-CoV-2 Prof. Dong-Yan Jin HK$8,431,247 Jan 5, 2021 Donation from “Chi Lin Kok Ng Buddhist Hall Limited” Cell replacement therapy against neurodegenerative disease Prof. Ying Shing Chan Collaborative Research Fund COVID-19 and Novel Infectious Disease 2020/21
Innovation and Technology Fund – Innovation and Technology Support Program (ITSP)
Project Title:
Development and pre-clinical evaluation of a humanized ANXA3 neutralizing monoclonal antibody for hepatocellular carcinoma treatment Dr. Stephanie Ma
Project Coordinator: Award Amount: Award Date:
HK$1,221,875 Mar 15, 2021
Contract Research Project Title: Project Coordinator: Amount Awarded: Award Date: Project Title: Project Coordinator: Award Amount: Award Date:
Research Impact Fund 2020/21 Project Title:
HK$500,000 Feb 15, 2021
Development and applications of a driver-dependent tumor organoid biobank for translational liver cancer research Dr. Stephanie Ma HK$4,100,000 (plus partner universities matching an additional $30%) Jan 13, 2021
Project Coordinator: Amount Awarded: Award Date:
Guangdong-Hong Kong-Macau RNA laboratory ( 粤港 RNA医学联合实验室 ) Prof. Jiandong Huang RMB1,000,000 Jan 8, 2021
Publications Highlights
1. Yuan S, Yin X, Meng X, Chan JF, Ye ZW, Riva L, Pache L, Chan CC, Lai PM, Chan CC, Poon VK, Lee AC, Matsunaga N, Pu Y, Yuen CK, Cao J, Liang R, Tang K, Sheng L, Du Y, Xu W , Lau CY , Sit KY, Au WK, Wang R, Zhang YY, Tang YD, Clausen TM, Pihl J, Oh J, Sze KH, Zhang AJ, Chu H, Kok KH, Wang D, Cai XH, Esko JD, Hung IF, Li RA, Chen H, Sun H, Jin DY , Sun R# , Chanda SK#, Yuen KY#. Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature 2021. doi: 10.1038/s41586-021-03431-4. Published 16 Mar 2021. #co-corresponding authors 2. Tan DS , Chen Y, Gao Y , Bednarz A , Wei Y, Malik V, Ho DH , Weng M , Ho SY , Srivastava Y, Velychko S, Yang X, Fan L, Kim J, Graumann J, Stormo GD, Braun T, Yan J, Schöler HR, Jauch R . Directed evolution of an enhanced POU reprogramming factor for cell fate engineering. Molecular Biology and Evolution 2021, msab075. doi: 10.1093/molbev/msab075. Published 15 Mar 2021. 3. Hossain MF, Wang N, Chen R , Li S , Roy J , Uddin MG, Li Z, Lim LW# , Song YQ# . Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer's disease neuropathology. Ageing Research Reviews 2021, 67:101304. doi: 10.1016/j.arr.2021.101304. Published 18 Feb 2021. #co-corresponding authors 4. Du Y , Yan Y , Xie S , Huang H, Wang X, Ng RK, Zhou MM, Qian C . Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation. Nature Communications 2021, 12(1):949. doi: 10.1038/s41467-021-21236-x. Published 11 Feb 2021. 5. Ye ZW, Yuan S, Chan JF, Zhang AJ, Yu CY , Ong CP , Yang D, Chan CC, Tang K, Cao J, Poon VK, Chan CC, Cai JP, Chu H, Yuen KY, Jin DY . Beneficial effect of combinational methylprednisolone and remdesivir in hamster model of SARS-CoV-2 infection. Emerging Microbes & Infections 2021, 1-38. doi: 10.1080/22221751.2021.1885998. Published 4 Feb 2021. 6. Huang Y , Jiang H, Zheng Q , Fok AH , Li X , Lau CG, Lai CS . Environmental enrichment or selective activation of parvalbumin-expressing interneurons ameliorates synaptic and behavioral deficits in animal models with schizophrenia-like behaviors during adolescence. Molecular Psychiatry 2021. doi: 10.1038/s41380-020-01005-w. Published 20 Jan 2021. 7. Dong C , An L , Yu CH# , Huen MS# . A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage. Nucleic Acids Research 2021, gkaa1290. doi: 10.1093/nar/gkaa1290. Published 19 Jan 2021. #co-corresponding authors 8. Ng KY , Shea QT, Wong TL , Luk ST , Tong M , Lo CM, Man K, Yun JP, Guan XY, Lee TK, Zheng YP, Ma S . Chemotherapy ‐ enriched THBS2 ‐ deficient cancer stem cells drive hepatocarcinogenesis through matrix softness induced histone H3 modifications. Advanced Science 2021. https://doi.org/10.1002/advs.202002483. Published 4 Jan 2021. 9. Zhu Y , Lam AKY, Shum DK , Cui D , Zhang J , Yan DD , Li B, Xu WW, Lee NP, Chan KT, Law S, Tsao SW , Cheung AL . Significance of serglycin and its binding partners in autocrine promotion of metastasis in esophageal cancer. Theranostics 2021, 2722-2741. doi: 10.7150/thno.49547. Published 1 Jan 2021. 10. Chen XK , Yi ZN, Wong GT, Hasan KM, Kwan JS#, Ma AC#, Chang RC# . Is exercise a senolytic medicine? A systematic review. Aging Cell 2021, e13294. doi: 10.1111/acel.13294. Published Jan 2021. #co-corresponding authors 11. Gao X#, Ruan D , Liu P# . Reprogramming porcine fibroblast to EPSCs. Methods in Molecular Biology 2021, 2239:199-211. doi: 10.1007/978-1-0716-1084-8_13. Published 2021. #co-corresponding authors 12. Wan YK , Choi GC , Wong AS . High-throughput protein engineering by massively parallel combinatorial mutagenesis. Methods in Molecular Biology 2021, 2199:3-12. doi: 10.1007/978-1-0716-0892-0_1. Published 2021. 13. Shiu SC , Sakai Y, Tanner JA# , Heddle JG#. FRET-mediated observation of protein-triggered conformational changes in DNA nanostructures. Methods in Molecular Biology 2021, 2208:69-80. doi: 10.1007/978-1-0716-0928-6_5. Published 2021. #co-corresponding authors
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