New Equipment School Highlights Multiplexing System (Luminex/ MAGPIX) Perform up to 50 different tests in a single reaction in 96-well plate format Location L1-05, Lab Block
Automated Western Blot System (biotechne ProteinSimple Wes) Fully automated western blotting workflow including separation by capillary electrophoresis, immunodetection and data analysis
Benchtop Vacuum Concentrator (LABCONCO/ CentriVap)
Rapid concentration of aqeuous sample in 1.5ml tube using centrifugal force, vacuum and heat
Tech-in-charge Mr. Owen Chan
Location L3-26, Lab Block Tech-in-charge Ms. Wan Ying Wong wywong@hku.hk +852-3917-9475
Location L1-41, Lab Block Tech-in-charge Ms. Carman Leung kmleung@hku.hk +852-3917-9425
owenchan@hku.hk +852-3917-9196
Real-Time PCR Instrument (Biorad/ CFX Opus 96) 96-well qPCR with WiFi for direct data transfer Location L3-30, Lab Block Tech-in-charge
Real-Time PCR Instrument (Biorad/ CFX Opus 384) 384-well qPCR with WiFi for direct data transfer
Location L4-06, Lab Block Tech-in-charge Ms. Molly Wong pfwong@hku.hk +852-3917-2832
Ms. Maggie Cheung maggiesh@hku.hk +852-3917-6811
Karyotyping microscope (Zeiss/ Axioscope) Fluorescent inverted microscope with AI-based karyotyping software Ikaros Location L4-06, Lab Block Tech-in-charge
FPLC (Cytiva/ AKTA pure) Chromatography system for customized protein purification Location L4-25, Lab Block Tech-in-charge Miss Samantha Wong
Ms. Connie Wong wmwonga@hku.hk +852-3917-9181
wongwwt@hku.hk +852-3917-9230
*Corresponding Authors | # Co-first Authors | ^Current RPG Students Publications Highlights
1. Poon CH^ , Tan SZ^* , Sheng V, Wang S, Aquili L, Lim LW* . A brief comparative look at experimental memory editing techniques for cognitive dysfunction. Curr Alzheimer Res. 2021 Dec 8. 2. Chong PS^# , Poon CH^# , Roy J^ , Tsui KC^ , Lew SY, Phang MW, Tan RJ, Cheng PG, Fung ML , Wong KH* , Lim LW* . Neurogenesis-dependent antidepressant-like activity of hericium erinaceus in an animal model of depression. Chin Med. 2021 Dec 7;16(1):132. 3. Qiao C , Huang Y* . Representation learning of RNA velocity reveals robust cell transitions. Proc Natl Acad Sci USA. 2021 Dec 7;118(49):e2105859118. 4. Lo Y^ , Cheung YW , Wang L^ , Lee M , Figueroa-Miranda G, Liang S, Mayer D, Tanner JA* . An electrochemical aptamer-based biosensor targeting plasmodium falciparum histidine-rich protein II for malaria diagnosis. Biosens Bioelectron. 2021 Nov 15;192:113472. 5. Wu MY#, Wong AY#, Leung JK, Kam C, Wu KL , Chan YS , Liu K, Ip NY, Chen S*. A near-infrared AIE fluorescent probe for myelin imaging: From sciatic nerve to the optically cleared brain tissue in 3D. Proc Natl Acad Sci USA. 2021 Nov 9;118(45):e2106143118. 6. Fang H^ , Zhu X^ , Yang H^ , Oh J , Barbour JA , Wong JW* . Deficiency of replication-independent DNA mismatch repair drives a 5-methylcytosine deamination mutational signature in cancer. Sci Adv. 2021 Nov 5;7(45):eabg4398. 7. Pan Y# , Shea YF*#, Ismail Z, Mak HK, Chiu PK, Chu LW, Song YQ . Prevalence of mild behavioural impairment domains: A meta-analysis. Psychogeriatrics. 2021 Nov 2. 8. Loh JJ^ , Ma S* . The role of cancer-associated fibroblast as a dynamic player in mediating cancer stemness in the tumor microenvironment. Front Cell Dev Biol. 2021 Oct 25;9:727640. 9. Vinel C, Rosser G#, Guglielmi L#, Constantinou M#, Pomella N, Zhang X, Boot JR, Jones TA, Millner TO, Dumas AA, Rakyan V, Rees J, Thompson JL, Vuononvirta J, Nadkarni S, El Assan T, Aley N, Lin YY, Liu P , Nelander S, Sheer D, Merry CL, Marelli-Berg F, Brandner S, Marino S*. Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma. Nat Commun. 2021 Oct 21;12(1):6130. 10. Thoms JA, Truong P, Subramanian S, Knezevic K, Harvey G, Huang Y, Seneviratne JA, Carter DR, Joshi S, Skhinas J, Chacon D, Shah A, de Jong I, Beck D, Göttgens B, Larsson J, Wong JW , Zanini F, Pimanda JE. Disruption of a GATA2-TAL1-ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells. Blood. 2021 Oct 21;138(16):1441-1455. 11. Xu F^# , Tong M# , Tong CS , Chan BK^ , Chu HY , Wong TL , Fong JH^ , Cheung MS , Mak KH , Pardeshi L, Huang Y , Wong KH, Choi GC , Ma S* , Wong AS* . A combinatorial CRISPR-Cas9 screen identifies ifenprodil as an adjunct to sorafenib for liver cancer treatment. Cancer Res. 2021 Oct 19:canres.1017.2021. 12. Lin J, Bao X* , Li XD*. Chemoproteomic approach for mapping binding sites of post-translational-modification-mediated protein-protein interactions. Trends Biochem Sci. 2021 Oct 9:S0968-0004(21)00207-3. 13. Yeung SF^ , Zhou Y , Zou W , Chan WL , Ching YP* . TEC kinase stabilizes PLK4 to promote liver cancer metastasis. Cancer Lett. 2021 Oct 9:S0304-3835(21)00435-3.
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