Dermatology The dermatology service includes research in inflammatory skin disease, including atopic dermatitis, psoriasis, lichen sclerosus, lichen planus, and hidradenitis suppurativa . Through active participation in research, the dermatology team is able to offer patients immediate access to the latest and most advanced medicines providing relief for conditions including adult and paediatric psoriaris, adult and paediatric atopic dermatitis and hidradenitis suppurativa. Selected current studies include: › M16-047 – a phase III clinical trial investigating efficacy of upadacitinib in combination with topical corticosteroids in adolescent and adult subjects with moderate to severe atopic dermatitis › PROTOSTAR – a phase III clinical trial evaluating the efficacy and safety of guselkumab for chronic plaque psoriasis in paediatric patients › HS0004 – a phase III clinical trials testing the efficacy of bimekizumab in adult subjects with moderate to severe hidradenitis suppurativa › B7451050 – a phase III clinical trial evaluating the efficacy and safety of abrocitinib and dupilumab in adult subjects with moderate to severe atopic dermatitis › LAAVA-2 – a phase I investigator-led clinical trial investigating the efficacy of fractional ablative CO2 laser for genitourinary symptoms of menopause
Hand Surgery The department of hand surgery and peripheral nerve surgery, based at RNSH, is involved in numerous research projects, including surgical outcome reviews, surgical technique developments (animal models), multi-centre international trials and publishing of case reports. The department receives Australian and international fellows each year and each actively pursues a research project during their term. In addition, hand surgery registrars from the Australian orthopaedic and plastic surgery training schemes join the department each year and are encouraged to undertake research, as are resident medical officers and medical students. Anatomical, mechanical and clinical studies completed within the department offer guidance on the best surgical options and outcomes for patients and regularly influence the practices of surgeons and hand therapists at NSLHD, but also at state, national and international levels. For example, a recent study on the care of spasticity patients after comprehensive one-stage upper limb surgery demonstrated a significant improvement through multidisciplinary care, which is now delivered in our multidisciplinary spasticity clinic. Our research is often run in collaboration with important partners, including the Children’s Hospital Westmead, RNSH’s department of orthopaedics, tetraplegia unit, multidisciplinary spasticity clinic, and the department of physiotherapy; The Kolling Institute’s Maxwell Murray Biomechanics Research Laboratory and Sutton Laboratories; The University of Sydney; international hospitals and universities (e.g. ERASMUS Medical Centre in Rotterdam, Netherlands; Loma Linda University, California, USA); and pharmaceutical companies and external groups with a hand surgery interest.
Publication highlights include: › Haines M, Baba M, Stewart DA. Iatrogenic femur fracture following medial femoral condyle flap harvest. J Hand Surg Am. 2020;S0363-5023(19)31532-1 › Ledgard JP, Gschwind CR. New developments in reconstructive upper limb surgery for tetraplegia: evidence for their efficacy. J Hand Surg Eur Vol. 2020;45(1):43‐50 › Mende K, Watson A, Stewart DA. Surgical treatment and outcomes of syndactyly: A systematic review. J Hand Surg Asian Pac Vol. 2020;25(1):1‐12 › Vanhees M, Cardillo ND, Hile MS. The effect of knot position in Adelaide flexor tendon repair. J Hand Surg Eur Vol. J Hand Surg Eur Vol. 2020;45(3):303‐304
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RESEARCH ANNUAL REPORT 2020
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