Plenary, Zero hunger (SDG 2), Good Health and Well-being (SDG 3)
Downsizing proteins and peptides
Norelle Daly Centre for Molecular Therapeutics, AITHM, James Cook University, Cairns.
Identification of small bioactive regions in proteins and peptides can be useful in drug design studies. One of the unique approaches to producing bioactive peptides is a process referred to as protein “downsizing”, where small, bioactive regions of proteins are produced in isolation. The approach generally involves detailed structural analysis of proteins and peptides to identify discrete elements of secondary structure which can be used in the design of small bioactive peptides. The designed peptides are likely to have lower immunogenicity and improved production yields relative to the parent proteins/ peptides. We have used this approach to design novel wound healing agents based on the granulin scaffold, and to develop anti-inflammatory peptides. These peptides have potential in the treatment of several diseases including diabetes, asthma and inflammatory bowel disease.
© The Author(s), 2023
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