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Two new polyacetylenes from the leaves of Cussonia Paniculata
Mohale B. Mabaleha* 1 & Susan Bonnet 2 1 Department of Chemistry & Chemical Technology, Faculty of Science & Technology, National University of Lesotho 2 Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, Republic of South Africa Polyacetylenes are biologically active compounds, which are characterised by one or more carbo-to- carbon triple bond. Although they are widely distributed in the plant kingdom (particularly in families of higher plants such as Araliaceae, Compositae, Santalaceae, Olacaceae, and Umbelliferae), they have also been reported in animals, bacteria, fungi, marine organisms and insects. The broad spectrum of biological activities exhibited by these compounds make them of great importance to both plant pathologists and pharmacologists 1 . In this study, two new polyacetylenes, 16-hydroxy- 9Z ,17-octadecadiene-12,14-diyne-1-oyl formate (1) and 9( Z )-octadecene-4,6-diyne-1,3,18-triol (2) were isolated from methanolic extract of the leaves of a Lesotho medicinal plant, Cussonia paniculata , using column chromatography (CC). Structure elucidation was achieved using spectroscopic techniques such as ultra-violet (UV), one-dimensional ( 1 H, 13 C) and two- dimensional (COSY, HSQC, HMBC, NOESY) nuclear magnetic resonance spectroscopy. Structure identity was confirmed using high-resolution mass spectrometry (HRMS) and by comparison of the experimental data with that obtained from the literature. The study presents a detailed account of structural elucidation of compound 1 . The study reports the structures of two new polyacetylenes. Biological assays shall be carried out to assess the biological activities of the isolated compounds, hence evaluating their possible applications in medicine.
Key words: Cussonia paniculata, polyacetylenes, medicinal plants, Lesotho, chromatography References 1. Hansen, L., Boll, P.M. (1986). Phytochemistry 25 (2): 285-293
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