Zero Hunger (SDG 2), Good Health & Well-being (SDG 3)
Synthesis, charcertisation and insilico investigtion of curcumin analogues as potential anti cancer drugs Padminee Ramsaroop*, Arvind Kumar Department of Chemistry, Faculty of Science and Technology, The University of the West Indies, St. Augustine Campus, St. Augustine, Trinidad and Tobago, West Indies Cancer is a deadly disease and is affecting the whole world. According to The World Health Organization, cancer is the second leading cause of death worldwide and is responsible for an estimated 9.6 million deaths in 2018. Cancer can be defined as a disease in which abnormal cells divide without control and invade nearby tissues. These cells then spread to other parts of the body via the blood and lymph systems. While there are many drugs currently on the market, many pose significant adverse side effects. One approach to combat to this issue is the use of Curcumin. Curcumin is a widely used polyphenol by people in many cultures. It can be extracted from the roots of the plant Curcuma longa or can be synthetically made. This plant extract has been shown to exhibit many pharmacological activities including anticancer, antiviral, antianxiety, antioxidant, antifungal, anti-inflammatory, neuroprotective, and cardioprotective properties. While there are many promising aspects of this compound, there are many hurdles that must first be overcome if this compound is to be used as an anti-cancer agent. Among these factors include improving solubility, stability, and bioavailability that is usually faced by free curcumin. This research looks at improving these factors by enhancing the curcumin molecule to build derivatives as well as complexing these derivatives with specific metals to create compounds that can be used as anti-cancer agents. For these analogues of curcumin AMDET profiles will be looked at for every compound to determine physiological properties and parameters such as medicinal chemistry, absorption, distribution, metabolism, excretion, toxicity, drug likeness and drug score. The promising derivatives will be selected for laboratory synthesis and would be characterized using techniques such as NMR ( 1 H, 13 C, HSQC, COSY), spectrometry (IR, UV-VIS, Mass, and Fluorescence) and thermogram (melting point and TGA). A comparative study on these analogues will then be tested on various cancer cell lines against known agents and free curcumin to determine their efficacy.
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