ApconiX Ltd
ApconiX was founded by Professor Ruth Roberts, Dr Michael Morton and Dr Richard Knight – colleagues with the drive and ambition to create a world-renowned pharmaceutical drug safety company. The journey began with the idea to provide life science companies with access to high quality drug safety expertise, normally available only in large pharmaceutical companies. ApconiX has previously won a Queen’s Award for Enterprise for International Trade in 2022 and a King’s Award for Enterprise for International Trade in 2024. Celebrating ten years of trading this year, ApconiX has grown to a strong team of over 100 people, helping clients all over the world to make better decisions on drug safety. There are three key elements to the business: a consultancy group that advises clients on drug safety and DMPK, a laboratory that screens new compounds for cardiac and central nervous system safety effects, and a Safety Science Group that combines toxicology expertise and advanced data science, offering customised Acuity® target safety assessments (TSAs), modality-focused reports as well as problem-solving expertise. ApconiX was awarded a King’s Award for Enterprise for Innovation for iSLA, an innovative assay that improves drug development safety
The ApconiX team of researchers who developed iSLA
Directors and Co-founders Dr Michael Morton, Professor Ruth Roberts and Dr Richard Knight
and success rates. iSLA was developed over three years and is based on original open-source research carried out by the company’s team in its laboratory. Richard says, “Toxicity is a major challenge in drug research and development. A pharmaceutical company will invest hundreds of millions to billions of pounds in a drug, only to fail in clinical trials.” There is a pressing need to develop new drugs to treat conditions such as cancer, and neurological conditions such as Alzheimer’s, Parkinson’s disease and epilepsy. iSLA, the ApconiX in-vitro Seizure Liability Assay, predicts if a compound in drug discovery or development might cause seizures.
Ruth comments, “Receiving the King’s Award is a tremendous honour and testament to the hard work, creativity and ambition of the whole team.” Michael adds, “Our aim is to find better solutions to identifying effective medicines quicker and at lower overall cost, in a sustainable and ethical manner.”The research was published in the Journal of Toxicological Sciences in October 2023.
APCONIX LTD Mereside, Alderley Park, Alderley Edge, Cheshire, SK10 4TG hello@apconix.com • www.apconix.com apconix
BromptonTechnology Ltd
Dunphy Combustion Ltd
Brompton Technology is an award-winning developer and manufacturer of LED processing technology, trusted in the most demanding applications across virtual production and ICVFX, live events and touring, broadcast and studio, corporate and esports sectors. Where the need is for high specification, mission critical, fast setup or on- camera solutions, that’s where Brompton pushes the boundaries of what’s possible in LED processing – always with a focus on best-possible image quality, usability, functionality and reliability. Since 2011, Brompton has forged a leading position in the industry through breakthroughs such as Dynamic Calibration and TrueLight®, and by building best-in-class LED processors, including the multi-award-winning Tessera SX40. As an industry-leading innovator, Brompton has also built platforms for the future in the Tessera G1, the most powerful receiver card ever to go into an LED panel, and its next-generation processing platform, launching with the world’s most powerful 8K video processor – the Tessera SQ200 – which is redefining the capabilities of LED systems. BROMPTONTECHNOLOGY LTD 272 Gunnersbury Avenue, Chiswick, London, W4 5QB Tel: 020 7471 9444 • support@bromptontech.com • www.bromptontech.com The award-winning Tessera SX40 LED processor
Dunphy Combustion, founded in 1964 and based in Rochdale, is the UK’s only remaining family-owned industrial burner manufacturer. It specialises in designing, manufacturing and servicing advanced burners, control systems and packaged plant rooms, exporting to over 60 countries.
It has won this year’s King’s Award for Innovation for its pioneering low-NOx burner, capable of safely burning any blend of hydrogen and natural gas, from 0% to 100%, simultaneously or independently. This technology is novel, and critical for industries aiming to reduce emissions and align with the UK’s net- zero goals, providing practical flexibility during the transition to cleaner fuels. Managing Director, Sharon Kuligowski, says, “I’m so proud of what we’ve achieved. This award recognises our team’s dedication over the last decade and is a testament to the foundations my dad laid. It means a great deal to all of us at Dunphy, reflecting our commitment to innovation, quality and a greener future.”
DUNPHY COMBUSTION LTD Queensway, Rochdale, Lancashire, OL11 2SL Tel: 01706 649217 • info@dunphy.co.uk • www.dunphy.co.uk dunphy-combustion-limited
www. kingsawardsmagazine .com
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