Sequence-controlled peptoid polymers Helen Tran Department of Chemistry, University of Toronto
The presentation of bioactive moieties in terms of multivalency, ligand density, and architecture plays a central role in biological recognition processes, including cellular adhesion and pathogen binding. Polypeptoids that self-assemble into two-dimensional (2D) nanosheets have potential to recapitulate these precise molecular recognition motifs onto a flexible platform for biosensing. The traditional solid-phase method for the synthesis of peptoids allows for precise control over the placement of potential recognition sites in the sequence, yet generates molecules on a small scale (~100 mg). Recent solution-phase synthetic methods have enabled gram- scale synthesis but lack sequence-specificity needed for self-assembly and precise incorporation of molecular recognition motifs. Herein, we present our motivations and efforts in bridging this divide. Moreover, we share our progress in replacing solvents traditionally used in the synthesis of peptoids with greener alternatives.
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© The Author(s), 2023
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