Kinetic investigation of RAFT photopolymerization in continuous flow using inline NMR analysis Magdalena A. Bereś 1 , Sébastien Perrier 1,2,3 , Tanja Junkers 4 1 Department of Chemistry, University of Warwick, UK, 2 Warwick Medical School, University of Warwick, UK, 3 Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Australia, 4 School of Chemistry, Monash University, Australia Photo Reversible Deactivation Radical Polymerization (photoRDRP) methods are widely applied in the synthesis of well-defined materials. Simple and more sustainable protocols as well as spatiotemporal control contributed to the popularity of photoRDRPs which was further aided by development of scalable protocols using flow polymerization platforms. Despite this popularity, we are still lacking many fundamental investigations concerning mechanism and kinetics of such reactions. Lack of accurate descriptions and inconsistencies of photoreaction set ups such as, but not limited to, light intensity and maxima of light wavelength used, lead to conflicting and irreproducible data. Herein, we apply an automated continuous flow platform featuring inline NMR analysis which allows for rapid kinetic screening via transient timesweep experiments for detailed investigation of photoRAFT (Reversible Addition-Fragmentation chain Transfer) of common acrylic monomers. Automation of experiments, data acquisition and analysis are achieved using a combination of Python and LabView scripts, allowing for rapid data acquisition under reproducible conditions. 1 Variable direct current power supply is used to control light intensity of light sources of different wavelengths to establish a relationship between light wavelength and intensity on control and rate of polymerization. References 1. J. Van Herck and T. Junkers, Chemistry–Methods , 2022, 2 , e202100090
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