HPMA-based polymers with different structures and their solution behavior Lenka Kotrchová, Libor Kostka, Michaela Hrochová, Tomáš Etrych Institute of Macromolecular Chemistry CAS, Czech Republic Water-soluble polymer materials are attractive for use in biomedical field research. N -(2-hydroxypropyl) methacrylamide (HPMA) based copolymers are known as versatile carrier systems for active pharmaceutical ingredients (API) delivery in cancer or inflammation treatment. 1, 2 Next to, these polymers are also studied as materials for tumor diagnostics or navigated surgery. Recently, the commercial application of HPMA-based carriers in the field of clinical in vitro diagnostics (IVD) was successfully launched. Many research groups study and develop HPMA-based polymeric systems, but the role of polymer structure on solution behavior has never been deeply studied. This study focused on the synthesis of polymers with various 3D architectures, from linear through diblocks to star-like systems. In the first part of the study, linear polymers and diblock polymers were synthesized. Suitable semitelechelic linear polymers were used to create star-like structures using the grafting to approach reaching the systems with polymer arms in the range 2–18. 3 Finally, the solution behavior was studied for all the polymer structures. Importantly, already three arms with a molecular weight of 20000 g/mol influence the solution behavior and shape of the star polymer chain in solution. Based on the results of the study we can conclude that the molecular weight of a water-soluble polymer chain is not the only critical parameter for proper characterization. The shape of molecules could easily change the solution behavior of the polymer molecules. Acknowledgment: This work was supported by the Czech Science Foundation (project no. GA23-05642S). References 1. K. Ulbrich, K. Holá, V. Šubr, A. Bakandritsos, J. Tuček and R. Zbořil, Chemical Reviews , 2016, 116 , 5338-5431. 2. A. Libanska, E. Randarova, S. Skoroplyas, M. Bartos, J. Lunackova, F. Lager, G. Renault, D. Scherman and T. Etrych, Journal of Controlled Release , 2023, 353 , 30-41. 3. L. Kostka, L. Kotrchová, V. Šubr, A. Libánská, C. Ferreira, I. Malátová, H. J. Lee, T. E. Barnhart, J. W. Engle, W. Cai, M. Šírová and T. Etrych, Biomaterials , 2020, 235 , 119728.
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