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organ weights, blood and biochemical parameters, histopathological changes in tissues, and other relevant endpoints. By examining these parameters, toxicologists can determine the potential toxic effects of the substance and establish dose-response relationships. Oral toxicology studies provide crucial data for regulatory agencies, such as the U.S. Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA), to assess the safety of substances intended for human consumption. The results of these studies help inform the establishment of safe exposure limits, the determination of appropriate warning labels or contraindications, and the identification of potential health hazards associated with oral exposure to substances.
It's worth noting that in recent years, there has been a growing interest in alternative methods to reduce reliance on animal testing in toxicology, including the development and application of in vitro models and computational toxicology approaches. These alternatives aim to improve the efficiency, predictability, and ethical considerations of oral toxicity testing while still ensuring human safety.
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