Riley Children's Health is a nationally ranked pediatric health system that uses expertise, innovation and the latest advancements to deliver the highest level of patient care to children and families in Indiana and across the nation.
ANNUAL REPORT
SPECIALTIES OVERVIEW AND PROGRAM DISTINCTIONS PUBLISHED OCTOBER 2025
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WELCOME TO RILEY CHILDREN’S HEALTH
TABLE OF CONTENTS Welcome to Riley Children’s Health Proud to be a nationally ranked children’s hospital About Riley Children’s Health Nursing at Riley Children’s Health Riley Children’s Health quality and safety highlights Pediatric specialties
FEATURED CONTENT RESEARCH HIGHLIGHTS > Gastroenterology: Research aims to inform new therapies for fatty liver disease in children. > Hematology, Oncology & Stem Cell Transplant: Oncologists lead CAR-T cell clinical trials for aggressive leukemias. > Nephrology: Challenging a decades-old standard, study uncovers new findings about kidney damage. > Pulmonology: Experts use $12 million grant to develop personalized therapy for severe asthma. MEDICAL MILESTONES > Cardiothoracic Surgery: Riley heart surgeon performs 200th heart transplant. > Maternal Fetal Medicine/Neurosurgery: Specialists collaborate on in-utero repair of severe form of spina bifida. PHYSICIAN HIGHLIGHTS > Mark D. Rodefeld, MD: Riley cardiothoracic surgeon earns prestigious award for development of Fontan pump. > Myda Khalid, MD: Pediatric nephrologist is nationally recognized in research and treatment of glomerular disease in children. > Charles B. Stevenson, MD: New division chief of pediatric neurosurgery aims to expand access to Riley subspecialty care.
LEADERSHIP TEAM David Biggerstaff, MHA President Vanessa Roshell-Stacks, MHA Vice President & Chief Operating Officer Mara E. Nitu, MD Vice President & Chief Medical Officer Amanda Noth-Matchett, PhD, MHA, RN, CENP, NEA-BC Interim Vice President & Chief Nursing Officer Mark P. Cain, MD, FAAP Vice President & Surgeon-in-Chief D. Wade Clapp, MD Chair, Department of Pediatrics, IU School of Medicine Judy Hollingsworth, MSN, RN, NE-BC Associate Vice Chair of Clinical Operations & Administrator of Ambulatory Services Sarah Currier Vice President & Chief Human Resources Officer Frank Runion Vice President & Chief Financial Officer Emily Haarman Chief of Staff
Delivering leading-edge clinical care is a hallmark of Riley Children’s Health. As we embark on our second century of serving children in Indiana and beyond, we remain committed to advancing research and treatment in pediatric healthcare. That’s why we’re proud to once again be ranked among the best children’s hospitals in the nation. For 2025 – 2026, 11 out of 11 Riley specialties are ranked by U.S. News & World Report , with three programs—Nephrology, Pulmonology and Urology— named among the top 10. From the exam rooms and operating rooms of Riley Children’s to the laboratories of the Herman B Wells Center for Pediatric Research , our pediatric health system is strengthened by our partnership with Indiana University School of Medicine. Together, Riley Children’s and IU School of Medicine are national leaders in externally funded research, forging discoveries that lead to new treatments for the most challenging and complex childhood diseases and conditions. At the forefront of innovation, Riley Children’s is a leader in advancing care. Highlighting just one remarkable example, earlier this year our fetal surgeons and maternal fetal medicine specialists performed Indiana’s first successful in-utero repair of myelomeningocele, a severe form of spina bifida. Providing this kind of exceptional care depends on two things— patients and families who trust Riley Children’s and a skilled team steadfastly committed to caring for children. We’re fortunate to have both. Our team members are the reason families put their trust in Riley Children’s. Their expertise and dedication have earned elite recognition from groups such as the American College of Surgeons and the American Nurses Credentialing Center. In treatment, research and family-centered care, we’re excited about the opportunities and potential of our next century. On behalf of our team, I thank you for your interest in Riley Children’s and our continuing efforts to improve the lives of children in Indiana and around the world.
Adolescent Medicine Allergy & Immunology Anesthesia Child Protection Critical Care Medicine Dentistry Dermatology Developmental Medicine Diabetes & Endocrinology
Diagnostic Radiology Emergency Medicine Gastroenterology General Pediatrics & Pediatric Primary Care Heart Center Cardiology Cardiothoracic Surgery Cardiac Critical Care Medicine Electrophysiology Interventional Cardiology Hematology, Oncology & Stem Cell Transplant Hospital Medicine Infectious Diseases
Interventional Radiology Maternal Fetal Medicine Medical & Molecular Genetics Neonatology Nephrology Neurology Neuroradiology Neurosurgery Ophthalmology Orthopedics
Otolaryngology Palliative Care Pediatric Surgery Physical Medicine & Rehabilitation Plastic Surgery Psychiatry Pulmonology & Sleep Medicine Rheumatology Transplant Surgery Trauma Services Urology Riley Children’s Health team member directory Refer a patient
David Biggerstaff, MHA President, Riley Children’s Health
Annual Report 2024 – 2025
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PROUD TO BE A NATIONALLY RANKED CHILDREN’S HOSPITAL U.S. News & World Report has ranked Riley Children’s Health among the best children’s hospitals in the nation. In 2025–26, Riley Children’s is ranked in 11 out of 11 pediatric specialties.
Riley Children’s Health, Indiana’s largest and most skilled pediatric health system, provides care in 22 communities across the state. Accreditations and designations ABOUT RILEY CHILDREN’S HEALTH
By the numbers
25,000+ ADMISSIONS AND OBSERVATIONS 475 BEDS 65+ PEDIATRICIANS 615+ SPECIALISTS ACROSS 40+ SPECIALTIES 23,800+ SURGICAL VOLUME 69,600+ EMERGENCY DEPARTMENT VISITS
CANCER
CARDIOLOGY & HEART SURGERY
Level I Children’s Surgery Center verified by the American College of Surgeons (ACS)
DIABETES & ENDOCRINOLOGY
GASTROENTEROLOGY & GI SURGERY
NEONATOLOGY
NEPHROLOGY RANKED 9 TH IN THE NATION
Level I Pediatric Trauma Center verified by ACS
Burn program verified by the American Burn Association
NEUROLOGY & NEUROSURGERY
ORTHOPEDICS
PEDIATRIC & ADOLESCENT BEHAVIORAL HEALTH
PULMONOLOGY & LUNG SURGERY RANKED 9 TH IN THE NATION
Platinum Center of Excellence designated by the Extracorporeal Life Support Organization
Earned Magnet®status, recognizing excellence in nursing care
UROLOGY RANKED 8 TH IN THE NATION
AFFILIATED WITH
Riley Children’s: A leader in research and innovation ■ A national leader in externally funded research ■ One of the largest pediatric research hospitals in the Midwest ■ Home to the Herman B Wells Center for Pediatric Research , the Children’s Clinical
“Our ranking by U.S. News & World Report highlights the incredible dedication of our entire team at Riley Children’s Health. Above all, it reflects our commitment to putting patients and families at the heart of everything we do. We strive every day to provide not only advanced medical care but also compassionate support that helps children and their families heal and thrive.” – Mara E. Nitu, MD Vice President & Chief Medical Officer Professor of Clinical Pediatrics, IU School of Medicine > Connect with Dr. Nitu on Doximity.
■ One of the largest medical schools in the U.S. ■ One of the busiest locations for pediatric research funded by the National Institutes of Health (NIH) and other sponsors ■ For federal fiscal year 2024, the IU School of Medicine Department of Pediatrics is ranked sixth in the nation for NIH research funding, totaling more than $44.2 million to support numerous pediatric studies.
Research Center and the Center for Children’s Health Services Research
Annual Report 2024 – 2025
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NURSING AT RILEY CHILDREN’S HEALTH
RILEY CHILDREN’S HEALTH QUALITY AND SAFETY HIGHLIGHTS ■ Top 50% of hospitals in prevention of central line-associated bloodstream infections (CLABSIs); second year in a row achieving this milestone ■ 25% decrease in CLABSIs in 2025 ■ Asthma patient readmissions decreased from 4.32% in 2024 to 1.93% through the second quarter of 2025 High-acuity units at Riley Children’s reach milestones in harm prevention ■ Cardiac intensive care unit: Zero CLABSIs for more than a year (491 days) * ■ Stem cell transplant unit: 112 days without a CLABSI ■ Neonatal intensive care unit: More than 233 days without a CLABSI ■ Pediatric intensive care unit: 301 days without a pressure injury * March 9, 2024 – July 13, 2025
TOP DISTINCTIONS
■ Only 10% of U.S. hospitals have earned Magnet designation; Riley Children’s is among the 1% of hospitals to be designated five times.
CLINICAL NURSES 1,539
■ Home to an entry-to-practice nurse residency program accredited by the Commission on Collegiate Nursing Education; accreditation earned in 2022.
EDUCATION
78% 15% 7%
BACHELOR OF SCIENCE IN NURSING
RESEARCH HIGHLIGHTS
ASSOCIATE OF SCIENCE IN NURSING
Select nursing research and best practices presented at conferences in 2024: ■ Clinical prevention of severe maternal morbidity ■ Maternity and newborn health perinatal outreach team OB-GYN simulations ■ Neuroprotective bundle in preterm infants: A quality improvement initiative to reduce severe intraventricular hemorrhage ■ Surfactant administration through laryngeal or supraglottic airways ■ Amplifying voices of another language: A nurse-led intervention to address the needs of patients, families and medical interpreters
GRADUATE DEGREE
CERTIFICATIONS
16% 10% 58%
CERTIFIED RNs
CERTIFIED CLINICAL NURSES
CERTIFIED NURSE LEADERS
DESTINATION FOR NURSES
IN 2024:
512 nurses hired 190 new nurses graduated from the nurse residency program at Riley Children’s
Annual Report 2024 – 2025
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The adolescent medicine specialists at Riley Children’s Health treat a wide variety of adolescent health issues, including reproductive health, eating disorders and gender health. Our fellowship- trained physicians routinely work with specialists in cardiology, hematology/oncology, child development, psychiatry, endocrinology, and obstetrics and gynecology to provide patient- centered, comprehensive care for young people up to age 25. ADOLESCENT MEDICINE
RESEARCH HIGHLIGHTS
NOTABLE PUBLICATIONS
Adolescent medicine specialists at Riley Children’s lead research in these areas: ■ Human papillomavirus (HPV) ■ HPV vaccines ■ Sexually transmitted infections ■ Healthcare access for youth ■ Eating disorders ■ Teen pregnancy prevention ■ Gender health ■ Long-term effects of illness and recovery on youth
The Journal of Adolescent Health: October 2024 The American Academy of
Pediatrics guideline for obesity: An adolescent health perspective; Lead author: Laura Hooper, PhD Sexually Transmitted Diseases: September 2024 The next 50 years: Sex/gender and the mitigation of stigma in sexually transmitted diseases;
TOP DISTINCTIONS
Adolescent Medicine Consultation Program We offer evaluation and Specialized programs
Charis Center for Eating Disorders Indiana’s most comprehensive eating disorders treatment program, the Charis Center provides medical, psychological, group therapy, nutritional and family support. The center offers inpatient and outpatient treatment options and facilitates more than 10,000 outpatient visits annually.
■ One of the largest divisions of its kind in the nation with high- volume clinical care, prolific grant-funded research and a robust training program ■ One of only nine nationally recognized Leadership Education in Adolescent Health (LEAH) programs; provides interdisciplinary training in the needs of adolescent and marginalized populations ■ One of the few programs regionally that serves the unique needs of patients experiencing gender dysphoria
Lead author: J. Dennis Fortenberry, MD, MS The Journal of Adolescent Health: December 2024 Targeting rural adolescent pregnancy: Modifiable
treatment for any adolescent health issue requiring more specialized treatment than is typical for primary care. Common referrals include: ■ Mental health and behavioral issues, including anxiety and depression and disordered attention ■ Nutritional concerns, including eating disorders ■ Co-management of chronic illness
Our physicians lead subspecialty training through a three-year Adolescent Medicine Fellowship . Fellows provide clinical care, conduct research, direct resident education and can earn a master’s degree in public health.
protective factors and contraceptive use
45 research publications in 2024
Adolescent Gynecology and Reproductive Health
Our physicians evaluate and treat a variety of gynecological conditions, including delayed puberty, abnormal uterine bleeding, polycystic ovary syndrome, chronic pelvic pain and dysmenorrhea. We offer specialized gynecology and reproductive healthcare, including long-acting reversible contraceptive options. Our specialists have extensive experience consulting patients and families about fertility preservation in complex illness. Riley Gender Health Program Our interdisciplinary program delivers legally comprehensive support to patients (up to age 25) and their families who are experiencing gender dysphoria and seek supportive, holistic and affirmative care.
■ Evaluation for chronic symptoms that lack a diagnosis
Adolescent Nutrition Program We provide comprehensive nutrition services, including an in-office dietitian offering personalized nutrition guidance tailored to the patient’s needs. ■ Weekly appointments available. ■ Healthy eating plan developed in collaboration with family and healthcare provider. More than 60 new patients
DIVISION CHIEF Rachel A. Katzenellenbogen, MD Professor of Pediatrics, IU School of Medicine > C onnect with Dr. Katzenellenbogen on Doximity.
Riley Children’s is committed to advocating for families of adolescents and young adults in Indiana and across the nation, with the goal of improving their health and wellness.
have benefited from this program since July 2024.
9 board certified physicians 9 psychologists
See full team member list >
Annual Report 2024 – 2025
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Allergy and immunology specialists at Riley Children’s Health are expertly trained in the management and treatment of pediatric allergy, asthma and immunology concerns. Our board certified physicians offer the latest diagnostic methods and treatments delivered in a safe and comfortable manner to children dealing with the challenges of allergy and immunology conditions. ALLERGY & IMMUNOLOGY
RESEARCH HIGHLIGHTS
NOTABLE PUBLICATIONS
■ Riley Children’s participates in PARK (Preventing Asthma in High Risk Kids), a multicenter clinical study led by the National Institute of Allergy and Infectious Diseases to investigate the impact of omalizumab to prevent severe asthma and new allergies in preschool-age children. ■ We are involved in multiple clinical trials and studies investigating the role of the airway microbiome in the development of allergic disease.
Annals of Allergy, Asthma and Immunology: May 2024 Decoding viral infections and risk for asthma: Biomarkers or clinical histories? Lead author: Kirsten M. Kloepfer, MD The Journal of Allergy and Clinical Immunology, In Practice: February 2025 Efficacy and safety: Safety of epicutaneous immunotherapy in peanut-allergic toddlers: Open-label extension to EPITOPE Blood: January 2025 One hundred thirty-four germ line PU.1 variants and the agammaglobulinemic patients carrying them OUR TEAM ALSO PUBLISHED IN: Science Immunology American Journal of Human Genetics
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Specialized programs
High-Risk Asthma Program This collaborative program addresses the medical and social needs of children and families with severe asthma. > Learn more. Gastrointestinal Eosinophilic Digestive Diseases Program Our multidisciplinary program allows children to see a pediatric allergist, gastroenterologist and dietitian during the same visit. Immune Dysregulation Program This program combines experts from rheumatology, immunology, hematology and infectious diseases to guide children with complex immune disorders. Immunogenetics Program Children with complex immune disorders receive the latest guidance from an immunologist, a geneticist and a genetic counselor.
■ Recognized for distinction in clinical care by Food Allergy Research and Education (FARE); performs more food challenges than any other program in Indiana ■ Indiana’s only multidisciplinary program for eosinophilic gastro- intestinal diseases ■ Member of the Jeffrey Modell Centers Network for treatment and research related to primary immunodeficiency diseases
Riley Children’s is a core member of the Severe Pediatric Asthma Consortium, a group focused on developing best practice guidelines and cultivating research initiatives.
■ Partners with the Indiana Department of Health to
Program Volume: 2023 – 2024
Allergy patient visits
Immunology patient visits 2023 745 2024 805
Oral food challenges
analyze all abnormal newborn screenings for severe combined immune deficiencies (SCIDs)
2023 5,680 2024 6,851
2023 389 2024 381
Professional organization affiliations American Academy of Pediatrics – Section on Allergy and Immunology Girish V. Vitalpur, MD, FAAP, FAAAAI American Academy of Allergy, Asthma & Immunology Jay J. Jin, MD, PhD, FAAAAI Simran K. Jutla, MD Kirsten M. Kloepfer, MD, MS, FAAAAI Nurcicek Padem, MD, MS Craig D. Sewell, DO Girish V. Vitalpur, MD, FAAP, FAAAAI
DIRECTOR Girish V. Vitalpur, MD, FAAP, FAAAAI Professor of Clinical Pediatrics, IU School of Medicine > Connect with Dr. Vitalpur on Doximity.
The inpatient penicillin allergy de-labeling protocol at Riley Children’s is used in hospitals across Indiana.
Clinical Immunology Society Jay J. Jin, MD, PhD, FAAAAI Nurcicek Padem, MD, MS
6 board certified physicians
See full team member list >
Annual Report 2024 – 2025
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The expert anesthesiologists at Riley Children’s Health deliver safe, evidence-based and compassionate care to pediatric patients in all areas of anesthesia, perioperative medicine, and acute and chronic pain management. In addition, our specialists are committed to leading innovative perioperative care research, providing high-quality clinical education and improving health outcomes. ANESTHESIA
RESEARCH HIGHLIGHTS
NOTABLE PUBLICATION
Grant-funded research related to: ■ Translating science into clinical practice to improve safety and efficacy of opioids in neonates, children and nursing mothers ■ Personalized perioperative analgesia platform for pediatric spine fusion surgery Committed to quality and safety Anesthesiology team members at Riley Children’s are actively involved in the statewide IU Health controlled substance stewardship and steering committees to enhance and guide safe opioid prescribing practices for all pediatric patients. The Riley acute pain management team implemented a grant- funded program to provide opioid lockboxes, pill cutters and other resources to acute pain management patients discharged from the hospital.
World Journal for Pediatric and Congenital Heart Surgery: July 2025 Liposomal bupivacaine versus plain bupivacaine for pain control following congenital cardiac surgery
TOP DISTINCTIONS
Specialized programs
Chronic Pain Management Program Harnessing the expertise of pain physicians, psychologists, and physical and occupational therapists, this multidisciplinary program provides psychological and procedural support for pediatric patients with chronic pain. The Chronic Pain Management Program treated approximately 900 patients in 2024 and performed more than 50 chronic pain procedures—a record number for our program. Acute Pain Management Program Skilled anesthesiologists provide leading-edge pain management for inpatient and outpatient procedures; use regional anesthesia and pain management protocols to enhance recovery and mitigate unwanted side effects.
■ Subspecialty anesthesia care for complex cardiac, neurosurgical and transplant surgeries, as well as acute and chronic pain management services ■ Nationally recognized in pediatric anesthesia and pain medicine research ■ Leader in the use of infant spinal anesthesia to minimize the need for general anesthesia Joined PALNET in 2024 Riley Children’s is one of 12 pediatric hospitals in the Pediatric Anesthesia Learning Network (PALNET), which promotes expertise in EEG-guided monitoring of anesthetic depth. This technique allows for more accurate and personalized dosing of anesthetic drugs, resulting in less emergence delirium, more stability and faster wake-ups. With the goal of improving patient outcomes, several members of our team have become experts in this technique and are training other anesthesiology professionals at Riley Children’s.
Anesthesia Encounters: 2022 – 2024
2022
2023
2024
Riley Hospital for Children Main OR
17,000 *
17,000 *
17,000 *
Cardiac Anesthesia Program The congenital cardiac anesthesia team delivers specialized care to children and adults with congenital and acquired cardiac disease who are undergoing diagnostic, interventional and surgical procedures. Transplant Anesthesia Program Providing 24/7 coverage for complex transplant cases, our physicians specialize in anesthesia care for children undergoing intra-abdominal and multivisceral transplants.
5,473
5,573
5,746
Riley Outpatient Center
Leading-edge technologies in
Riley Children’s Health at IU Health North
2,327
3,448
3,256
cardiac anesthesia TEG 6S, a new point- of-care diagnostic
Total
24,800
26,021
26,002
modality, allows real-time assessment and treatment
* Estimated total for Main OR
of bleeding disorders during cardiac surgery.
DIVISION CHIEF Rania K. Abbasi, MD, FASA Associate Professor of Clinical Anesthesia, IU School of Medicine > Connect with Dr. Abbasi on Doximity.
35 board certified physicians
See full team member list >
Annual Report 2024 – 2025
CHILD PROTECTION
RESEARCH HIGHLIGHTS
Child protection specialists at Riley Children’s are active in national and local organizations, including: ■ American Academy of Pediatrics Council on Child Abuse and Neglect ■ American Academy of Pediatrics Trauma Informed Care Champion ■ American Academy of Pediatrics Council on Foster Care Adoption and Kinship Care ■ U.S. Department of Health and Human Services Children’s Justice Act Task Force ■ USA Gymnastics Safe Sport Committee ■ Ray E. Helfer Society, including the executive committee (treasurer) ■ Local and state child fatality review teams and child advocacy centers
Child Protection at Riley Children’s Health offers multidisciplinary clinical services and education to improve the evaluation and care of maltreated children. Our team of board certified physicians provides evidence-based consultation in cases of suspected child maltreatment. These consultations are objective assessments to help determine the extent of injury and whether a medical cause or an accidental mechanism accounts for the injury pattern.
Our physicians are currently engaged in research related to: ■ Evaluation of physical abuse when domestic violence occurs ■ Disparities in evaluation and reporting of drug ingestions by children ■ Radiography use in assessing possible child maltreatment – Use of postmortem body CT scans to evaluate occult injuries – Spinal fractures in children evaluated for nonaccidental trauma ■ Statewide placement and health outcomes for Black children in foster care ■ Costochondral junction variations in children younger than 2 years ■ Diagnosis of metaphyseal variations and classic metaphyseal lesions in the knees
Specialized programs
TOP DISTINCTIONS
Child Abuse Consultation Service Child protection specialists facilitate comprehensive medical evaluations for children alleged to have been physically abused or neglected.
Docs InCASE Program Our team, collaborating with 15 pediatric practices in Indiana, facilitates pediatric care and coordination in advancing the medical role in child protection. Foster Care Bridge Program Riley Children’s offers a trauma- informed, multidisciplinary clinic to serve as a bridge—providing comprehensive healthcare and acquiring appropriate resources for children entering and making transitions within the foster care system until a permanent medical home is identified. The child protection team led 62 community education programs in 2024.
■ Extensive history of collaboration and care coordination with healthcare providers, child protection case managers, law enforcement and the judicial system ■ Consults with the Indiana Department of Child Services (DCS) on more than 7,000 cases of suspected child maltreatment each year ■ Home to one of only 31 ACGME-accredited child abuse pediatrics fellowship programs in the nation
Pediatric Center of Hope Riley specialists in child abuse pediatrics provide comprehensive medical
evaluation for children alleged to have been sexually abused. Crisis Counseling Services These services bridge the gap from the time a child is identified as a possible child sexual abuse victim to when formal ongoing counseling may become available.
Foster Care Bridge Program Encounters: 2021 – 2024
234
222 214
2021–22
2022–23
2023–24
Physical and Sexual Abuse Consultations by Year: 2020 – 2024
7,178
Children Served: 2024
6,272
Child abuse consults 6,485 Pediatric Center of Hope consults 693
5,373 5,495
DIVISION CHIEF Shannon L. Thompson, MD, FAAP Associate Professor of Clinical Pediatrics, IU School of Medicine > Connect with Dr. Thompson on Doximity.
Crisis counseling 632 DCS consults 7,178
5 board certified physicians
See full team member list >
2020–21
2021–22
2022–23
2023–24
Annual Report 2024 – 2025
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CRITICAL CARE MEDICINE The 37-bed PICU at Riley Children’s Health provides skilled care to critically ill infants, children and adolescents. According to the Children’s Hospital Association, the PICU located at Riley Hospital for Children in downtown Indianapolis is one of the highest acuity centers in the United States. With all pediatric medical and surgical subspecialties represented, the PICU delivers a collaborative model for the care of a large volume of high-acuity diseases and injuries.
RESEARCH HIGHLIGHTS
NOTABLE PUBLICATIONS
■ 17 clinical trials and observational studies underway in critical care at Riley Children’s, including 11 funded by the National Institutes of Health, one funded by the U.S. Department of Defense and one funded by the Centers for Disease Control and Prevention Active in national and international studies focused on: ■ Hemodynamics changes in patients with severe malaria (Uganda) ■ Use of bubble CPAP in a pediatric teaching hospital (Liberia) ■ Biomarkers for respiratory failure in hematopoietic transplant patients ■ Use of respiratory support practices in PICUs across the U.S. (study conducted through the PICU Data Collaborative)
Nature: August 2024 Molecular mimicry in multisystem inflammatory syndrome in children Nature Medicine: July 2024 Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation Lancet (London, England): October 2024 RSV vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA Chest: November 2024 Framework for research gaps in pediatric ventilator liberation
Specialized programs Procedural Sedation Team ■ Facilitated 1,697 procedural sedations in 2024 ■ Only program in Indiana to offer nitrous oxide for moderate procedural sedation (112 completed in 2024) Advanced technologies ■ Etiometry ■ High-frequency oscillatory ventilation ■ Inhaled nitric oxide ■ Kinetic therapy rotational bed ■ Continuous renal replacement therapy (CRRT) ■ Aquapheresis
Committed to quality and safety
TOP DISTINCTIONS
■ Platinum Level ECMO Center of Excellence designated by the Extracorporeal Life Support Organization ■ Serves the critical care needs of Indiana’s largest pediatric trauma program
■ Reduced hospital-acquired harm The Riley PICU has significantly reduced the number of central line infections, pressure injuries and catheter-associated urinary tract infections. In 2024, our central line infection rate was 1.24 per 1,000 line days—lower than the national benchmark of 1.52. ■ CRRT support 60 patients were supported with CRRT in 2024. Additionally, the Riley PICU provided postoperative care for 20 children undergoing solid organ transplants. ■ Improved communication Nursing-integrated rounds and a standardized approach to communicating with families are being used to improve team collaboration and family experience during critical illness.
80 research publications in 2024
Professional organization affiliations CO-CHAIR, INTERNATIONAL COMMITTEE Pediatric Cardiac Intensive Society Adnan Bhutta, MD, FAAP, FCCM
■ The state’s only pediatric hospital with a dedicated burn ICU
MEMBER, AMERICAN HEART ASSOCIATION YOUNG HEARTS PEDIATRIC AND CONGENITAL CRITICAL CARE CARDIOLOGY COMMITTEE Council on Lifelong Congenital Heart Disease and Heart Health in the Young Adnan Bhutta, MD, FAAP, FCCM CHAIR, SPECIAL INTEREST GROUP ON GUIDELINES Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Samer M. Abu-Sultaneh, MD, FAAP, FCCM MEMBER, PREVENT SUBGROUP PALISI Samer M. Abu-Sultaneh, MD, FAAP, FCCM CHAIR, SCIENTIFIC OVERSIGHT COMMITTEE Extracorporeal Life Support Organization Matthew L. Friedman, MD CHAIR, HEMATOPOIETIC CELL TRANSPLANT, CANCER AND IMMUNOTHERAPY SUBGROUP PALISI Courtney M. Rowan, MD, MS MEMBER, SCIENTIFIC STEERING COMMITTEE PALISI Courtney M. Rowan, MD, MS CORE MEMBER PODIUM-Onc Initiative Courtney M. Rowan, MD, MS
OUR TEAM ALSO PUBLISHED IN: The Lancet Global Health The Journal of Pediatrics
■ Center of Excellence in Pediatric Sedation; designated by the Society for Pediatric Sedation ■ Serves as the medical control for the state’s largest pediatric critical care transport team
■ Indiana’s only pediatric critical care fellowship
3,168
2,872
2,752
DIVISION CHIEF Adnan Bhutta, MD, FAAP, FCCM Professor of Pediatrics, IU School of Medicine > Connect with Dr. Bhutta on Doximity.
2,425
Average daily census of 34.3
PICU Annual Admissions: 2021 – 2024
30 board certified physicians
See full team member list >
2021
2022
2023
2024
Annual Report 2024 – 2025
877.247.1177 IU Health 24/7 Transfer Center
The pediatric dentists at Riley Children’s Health—faculty members of Indiana University School of Dentistry—are skilled in providing comprehensive dental care to children of all ages. Riley dentists have extensive experience in treating children with complex medical issues. These conditions include physical disabilities, craniofacial anomalies, genetic disorders, liver and kidney disease, bleeding disorders, and congenital and acquired heart problems. Our team works closely with Riley specialists to optimize health outcomes for these medically compromised patients. DENTISTRY
RESEARCH HIGHLIGHT
NOTABLE PUBLICATIONS
Pediatric dentistry at Riley Children’s is in the third year of a five-year grant from the Health Resources & Services Administration. The grant funds efforts to improve children’s access to dental care and provide preventive and restorative services, while working with the medical community to educate future primary care providers. Professional organization affiliations COMMITTEE ON SPECIAL NEEDS American Academy of Pediatric Dentistry LaQuia A. Vinson, DDS, MPH COUNCIL ON SCIENTIFIC AFFAIRS American Academy of Pediatric Dentistry Allison C. Scully, DDS, MS DIRECTOR American Board of Oral Medicine Juan F. Yepes, DDS, MD, MPH, MS, DrPH COMMITTEE ON PEDIATRIC DENTAL SEDATION American Academy of Pediatric Dentistry Brian J. Sanders, DDS, MS COMMITTEE ON DIVERSITY, EQUITY AND INCLUSION American Cleft Palate and Craniofacial Association LaQuia A. Vinson, DDS, MPH EXAMINATION COMMITTEE American Board of Pediatric Dentistry LaQuia A. Vinson, DDS, MPH ASSOCIATE EDITOR Journal of the American Dental Association Juan F. Yepes, DDS, MD, MPH, MS, DrPH SITE VISITOR Commission on Dental Accreditation LaQuia A. Vinson, DDS, MPH Juan F. Yepes, DDS, MD, MPH, MS, DrPH
Pediatric Dentistry: May 2024 Effect of different isolation methods on bioaerosol distribution: An in vitro study Pediatric Dentistry: January 2024 Supplemental oxygen concentrations and the use of suction to mitigate risk of oral surgical fires using a laboratory model Pediatric Dentistry: May 2024 Longitudinal follow-up comparing future care of primary teeth treated with silver diammine fluoride: A private dental claims review Pediatric Dentistry: March 2024 Occupational noise exposure in the pediatric dental setting
Advanced technologies
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■ Riley Children’s is one of the few craniofacial centers in the Midwest to provide presurgical orthopedics using DynaCleft® tape to help align soft tissues and bones. ■ With iTero,®the newest digital scanner, we are able to expand the diagnostic and orthodontic services available to patients.
■ Nationally recognized faculty with diverse expertise in dental care of children with special medical, emotional and psychological needs ■ Team includes dentists board certified in oral radiology, oral medicine, pediatric dentistry and orthodontics
A high-volume practice, the Riley Dental Center has 5 full-time faculty, 9 part-time faculty and 14 residents on staff.
■ Indiana’s only pediatric dental residency program
Our team sees as many as 130 patients a day.
Dentistry for the Child and Adolescent , the longest-running international textbook in pediatric dentistry, was written by dentistry faculty at Riley Children’s and medical colleagues at IU School of Medicine. Originally published in 1963, the textbook has been translated into eight languages. The 11th edition was released in 2021.
DIVISION CHIEF Brian J. Sanders, DDS, MS Chair of Pediatric Dentistry, IU School of Dentistry > Connect with Dr. Sanders on Doximity.
Riley Dentistry Volume: 2024
Patient visits 14,053
New patients 2,189
Dental OR surgeries 814
4 board certified pediatric dentists
See full team member list >
Annual Report 2024 – 2025
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Board certified pediatric dermatologists at Riley Children’s Health provide high-quality care and the latest treatments for common dermatological conditions, such as eczema and acne, and more complex disorders of the skin. Through expert diagnosis and interventions, our goal is to improve quality of life for children with skin disease. DERMATOLOGY
RESEARCH HIGHLIGHTS
NOTABLE PUBLICATIONS
■ National study to define diagnostic criteria for hemangiomas associated with LUMBAR syndrome ■ Study investigating the clinical features and genetic mutations associated with vascular overgrowth syndromes ■ Comprehensive review article describing dental anomalies in congenital ichthyoses ■ National study focused on the long-term sequelae of PHACE syndrome ■ Research aimed at understanding hemangiomas that experience aggressive ulceration
The Journal of Pediatrics: September 2024
Dephi consensus on diagnostic criteria for LUMBAR syndrome Pediatric Dermatology: March-April 2025 Case report and literature review of dental abnormalities in congenital ichthyoses
Specialized programs
Advanced technologies and procedures Pulsed-dye and Nd:YAG laser treatments Specialized surgical procedures targeting birthmarks, port wine stains and other vascular tumors and malformations.
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Hemangioma Program Specialized experts at Riley Children’s evaluate and treat children with infantile hemangiomas; offer the latest therapeutic options and participate in international clinical studies. Vascular Lesions Program We provide skilled multidisciplinary care for children with complex vascular tumors and malformations, including: ■ Congenital hemangiomas ■ Infantile hemangiomas ■ Kaposiform
■ Nationally recognized experts in vascular anomalies with a dedicated multidisciplinary program that provides leading- edge care for children with vascular birthmarks ■ Only pediatric dermatologists in Indiana who are current or past leaders of the Birthmarks Research Group of the Pediatric Dermatology Research Alliance and the Hemangioma Investigator Group ■ Expertise using newly approved biologic medicines for eczema, psoriasis and other inflammatory skin diseases
Professional organization affiliations PRESIDENT Society of Pediatric Dermatology Anita N. Haggstrom, MD, FAAD MEMBER Pediatric Dermatology Research Alliance Anita N. Haggstrom, MD, FAAD
Approximate number of children served by our dermatology program each year:
Anshika Kaushik, MD Jenna Streicher, MD Elham Zayed, MD MEMBER
400 with vascular anomalies
Hemangioma Investigator Group Anita N. Haggstrom, MD, FAAD
hemangioendothelioma ■ Venous malformation ■ Lymphatic malformation ■ Other complex vascular syndromes ■ Sturge-Weber syndrome
150 inpatient consults
We offer unique access to a coordinated care model with specialists from dermatology, hematology/oncology, interventional radiology, otolaryngology, plastic surgery and physical therapy.
12,000+ outpatient visits
DIVISION CHIEF Anita N. Haggstrom, MD, FAAD Professor of Dermatology and Pediatrics, IU School of Medicine > Connect with Dr. Haggstrom on Doximity.
4 board certified physicians
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Our Vascular Lesions Program is a referral destination for patients in Indiana and the Midwest.
Annual Report 2024 – 2025
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Highly trained clinicians at Riley Children’s Health care for infants and children with neurodevelopmental disabilities, including those who may have co-occurring emotional or behavioral concerns. Our specialists develop personalized treatment plans to ensure each child receives the care they need. We work in teams comprised of board certified physicians, psychologists, pediatric nurse practitioners, speech pathologists, dietitians, genetic counselors, social workers and other professionals. DEVELOPMENTAL MEDICINE
The latest Down syndrome healthcare guidelines were written by Riley developmental medicine physicians in collaboration with the American Academy of Pediatrics.
RESEARCH HIGHLIGHTS
Global health research Funded by the National Institutes of Health (NIH) The Alama Project: Autism Outcomes and Neurobehavior Markers in Young Children Born to Mothers with HIV in Kenya ■ Five-year project to examine autism diagnostic outcomes and eye-tracking markers in young children with and without HIV exposure while building capacity for neuro-health research in western Kenya. Funded by the Indiana Clinical and Translational Sciences Institute Child Neurodevelopment Beyond Borders ■ Project to build a collaborative U.S.-India partnership to deepen understanding of the knowledge, attitudes and practices regarding autism detection and diagnosis in individuals of Indian origin. Mental health research study funded by the NIH Riley Developmental Medicine is part of a large multisite research study focused on harnessing advances in machine learning and novel clinical measures to improve prediction, diagnosis and treatment of mental health conditions in children and teens. Developmental Medicine has a registry and database that support a robust research program focused on improving care and increasing understanding of the patients we care for at Riley Children’s.
Specialized programs
Advanced technologies Riley Children’s offers the
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Virtual Autism Assessments We provide two-hour virtual autism assessments—a research-based method of evaluating young children for autism from the comfort of their own homes.
Angela M. Tomlin, PhD, HSPP, and Stephan A. Viehweg, ACSW, LCSW, published the second edition of Tackling the Tough Stuff: A Home Visitor’s Guide to Supporting Families at Risk. The book provides guidance and resources to the home visiting workforce on relationship-based and reflective practice approaches when working with families with high risk. Leadership in training and education ■ IU School of Medicine Developmental-Behavioral Pediatrics Fellowship Program ■ Leadership Education in Neurodevelopmental Disabilities (LEND) ■ IU School of Medicine Neurodevelopmental Disabilities Residency Program latest genetic testing, including exome and genome sequencing. We have genetic counselors embedded within our division and collaborate with Riley Medical & Molecular Genetics .
■ Six physicians board certified in neurodevelopmental disabilities; one physician board certified in developmental-behavioral pediatrics ■ Home to the only psychologist in Indiana trained in the Early Start Denver Model behavioral therapy program for children with autism ■ Three psychologists certified in perinatal mental health; four psychologists trained in parent- child interaction therapy ■ Home to one of only eight neurodevelopmental disabilities residency training programs worldwide
Parent-Child Interaction Therapy (PCIT)
Our psychologists provide PCIT to empower parents through coaching as they interact with their children using PRIDE (Praise, Reflection, Imitation, Description and Enjoyment) skills.
CO-DIVISION CHIEF Celanie K. Christensen, MD, MS, FAAP Associate Professor of Clinical Pediatrics and Neurology, IU School of Medicine > Connect with Dr. Christensen on Doximity.
Complex Care Inpatient Service Multidisciplinary team
NOTABLE PUBLICATIONS
manages inpatient care for children with cerebral palsy, myelomeningocele, feeding problems, Down syndrome and other chronic conditions. Spina Bifida Program Our multidisciplinary program now offers care coordination services to help families navigate the complexities of the healthcare system and ensure patients are meeting their goals.
JAMA Network Open: May 2024 Eye-tracking biomarkers and autism diagnosis in primary care Autism: April 2025
Developmental Medicine Outpatient Visits: 2022 – 2024
Nominated for the 2024 Summary of Advances by the Interagency Autism Coordinating Committee
Accuracy of the screening tool for autism in toddlers and young children in the primary care setting
11,622
10,514
9,562
CO-DIVISION CHIEF Angela M. Tomlin, PhD, HSPP Professor of Clinical Pediatrics, IU School of Medicine > Connect with Dr. Tomlin on Doximity.
Journal of Developmental and Behavioral Pediatrics: November-December 2024 Training and sustaining: Training and learning collaborative outcomes across a statewide network for early autism diagnosis
20 board certified physicians
See full team member list >
2022
2023
2024
Annual Report 2024 – 2025
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Diabetes and endocrinology specialists at Riley Children’s Health deliver expert care for infants, children and adolescents with diabetes and other endocrine disorders. Our board certified physicians have completed additional subspecialty training in pediatric endocrinology and pediatric diabetology. Ten certified diabetes and education specialists provide a wide range of resources and support to patients and their families. DIABETES & ENDOCRINOLOGY
RESEARCH HIGHLIGHTS
Professional organization affiliations VICE CHAIR Type 1 Diabetes TrialNet Linda A. DiMeglio, MD, MPH SECRETARY Pediatric Endocrine Society Erica A. Eugster, MD CHAIR, PEDIATRIC ENDOCRINOLOGY SUBBOARD American Board of Pediatrics John S. Fuqua, MD CHAIR, TYPE 2 DIABETES WORKING GROUP Type 1 Diabetes Exchange Quality Improvement Collaborative Tamara S. Hannon, MD CO-CHAIR BRAINY-T1D Consortium Linda A. DiMeglio, MD, MPH ASSOCIATE EDITOR Diabetes Care Emily K. Sims, MD
19 active research studies
■ Collaborating with the Herman B Wells Center for Pediatric Research , Riley Children’s is a research study site for novel
endocrine and diabetes therapies to address precocious puberty, Turner syndrome, Noonan syndrome, growth hormone deficiency and Type 2 diabetes. ■ Riley Children’s is one of 18 international centers participating in TrialNet , a major research network focused on Type 1 diabetes prevention and treatment. ■ Our investigators are also involved in studies of the microbiome in Type 1 diabetes, as well as research related to new technologies and therapeutics. We are engaged in clinical trials for therapies designed to modify the course of Type 1 diabetes: ■ TADPOL (Targeting Type 1 Diabetes via Polyamines) Phase II study evaluating the efficacy and safety of difluoromethylornithine ■ JAKPOT T1D NIH-funded Phase II trial evaluating janus kinase inhibitors abrocitinib and ritlecitinib
Premier programs
Novel procedures and advanced technologies
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Riley Children’s is a clinical trial site for therapies designed to modify the course of Type 1 diabetes. This includes a study examining the safety and efficacy of the breakthrough therapy teplizumab in children younger than 8 years old with early-stage disease. In 2023, a patient at Riley Children’s became the first child in Indiana to receive teplizumab .
■ One of the first pediatric programs in the Midwest (and first in Indiana) to administer teplizumab (the first FDA- approved preventive treatment for Type 1 diabetes) ■ Only comprehensive care center in the Midwest for congenital adrenal hyperplasia; one of eight Comprehensive Care Centers
■ Early-Stage Type 1 Diabetes Program ■ Endocrine Diseases Newborn Screening Program (statewide) ■ Youth Diabetes Prevention Program (for children at risk for diabetes) ■ Multidisciplinary programs – Differences of Sex Development Program – Gender Health Program – Late Endocrine Effects of Cancer Therapy Program – Metabolic Bone Disease Program – Muscular Dystrophy Program ■ Young Adult Diabetes Transition Program
of Excellence in the nation (designated by the CARES Foundation)
NOTABLE PUBLICATIONS
Training the next generation
Journal of Clinical Endocrinology and Metabolism: September 2024 Insulin dynamics and pathophysiology in youth-onset Type 2 diabetes Journal of Clinical Endocrinology and Metabolism: May 2025 Bone accrual trajectories in children and adolescents with perinatal HIV infection Communications Medicine (London): April 2024 Islet antibodies as precision diagnostic tools to characterize heterogeneity in Type 1 diabetes: A systematic review Lead author: Jamie L. Felton, MD Endocrinology and Metabolism Clinics of North America: June 2024 Presentation and care of children with peripheral precocious puberty OUR TEAM ALSO PUBLISHED IN NUMEROUS OTHER PUBLICATIONS, INCLUDING: 65 research publications in 2024
■ Linda A. DiMeglio, MD, MPH , is co-principal investigator of DiabDocs , a National Institutes of Health (NIH)-funded physician-scientist career development program. ■ Riley Children’s and IU School of Medicine have a leading pediatric endocrinology and diabetology fellowship . ■ Alexander R. Tuttle, MD , and Erika L. Zevin, MD , are co- leaders of the IU site for the Endocrine Society Medical Student Engagement Program. ■ IU School of Medicine leadership: Emily C. Walvoord, MD , serves as associate dean for student affairs and Zeina M. Nabhan, MD , is associate dean of graduate medical education.
■ Active in clinical and translational research studies for diabetes and endocrine disorders
BY THE NUMBERS
The diabetes program at Riley Children’s is accredited by the Association of Diabetes Care and Education Specialists.
Clinical locations 8
Patients seen annually Diabetes 1,600 Endocrine 8,230
DIVISION CHIEF Linda A. DiMeglio, MD, MPH Edwin Letzter Professor of Pediatrics, IU School of Medicine > Connect with Dr. DiMeglio on Doximity.
New clinical practice guideline Endocrinologists at Riley Children’s co-authored the Pediatric Endocrine Society Statement on Considerations for Use of Teplizumab in Clinical Practice , published in April 2024.
Years of cumulative experience
Teaching and Learning in Medicine Diabetes Obesity and Metabolism
Physicians 296 Advanced practice providers
17 board certified physicians
See full team member list >
173
Annual Report 2024 – 2025
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Pediatric and interventional radiologists at Riley Children’s Health specialize in the diagnosis of medical conditions in infants, children and adolescents. Our fellowship-trained radiologists use advanced radiologic technologies tailored to the needs of children. DIAGNOSTIC RADIOLOGY
RESEARCH HIGHLIGHT
NOTABLE PUBLICATIONS
Riley Diagnostic Radiology is conducting grant-funded research performing and analyzing postmortem CT scans in cases of suspected child abuse. The research aims to provide new insights in the study of child abuse imaging.
Pediatric Radiology: September 2024 Prenatal hydrocolpos: Imaging findings and differential diagnosis Emergency Radiology: February 2025 Comparison of clinical and abdominal CT imaging findings in children evaluated for abusive and Single-center study conducted at Riley Children’s
■ 3 Tesla (T) and 1.5T magnetic resonance imaging (MRI) scanners offering both advanced imaging sequences and fast-imaging techniques that reduce the need for sedation in young children ■ Siemens SOMATOM Force computed tomography (CT) scanner delivering exceptionally fast temporal resolution for imaging complex congenital heart disease in very small patients ■ CT scanners that allow organs to be viewed in different planes or as three-dimensional images
■ Fluoroscopy rooms that use advanced low-dose fluoroscopy equipment and can reduce X-ray dosage by as much as 70% ■ Digital radiology units that produce high-quality images quickly and shorten exam times ■ Ultrasound units specifically designed for pediatric imaging ■ On-site interventional radiology suite
Professional organization affiliations VICE CHIEF OF RADIOLOGY American Academy of Pediatrics Brandon P. Brown, MD, MA, FAAP CHAIR, CHILD ABUSE IMAGING COMMITTEE Society for Pediatric Radiology Megan B. Marine, MD INDIANA STATE COUNCILOR American College of Radiology Matthew R. Wanner, MD, FACR, FAAP BOARD OF DIRECTORS Society for Pediatric Radiology Brandon P. Brown, MD, MA, FAAP BOARD OF DIRECTORS Association of Academic Radiologists Brandon P. Brown, MD, MA, FAAP CHAIR, FACULTY DEVELOPMENT PROGRAM
Single-center study conducted at Riley Children’s
accidental abdominal trauma
Advanced technologies EOS X-ray technology
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33 research publications in 2024
■ One of the nation’s top centers for research and expertise in child abuse imaging ■ 3T fetal MRI program provides advanced imaging for diagnosis and treatment of congenital brain and body anomalies ■ Only facility in Indiana with attending pediatric radiologists on site 24/7/365
The American College of Radiology has accredited Riley Children’s in: ■ CT ■ MRI ■ Nuclear medicine ■ Ultrasound
Provides the highest quality images with the lowest possible dose of radiation. SPECT/CT Allows a cross-sectional rendering of nuclear medicine images. The CT image is fused to the nuclear medicine image for precise localization of areas on the SPECT image, allowing for a more accurate diagnosis. MRI
Association of University Radiologists Richard B. Gunderman, MD, PhD, FACR PEDIATRIC EDUCATION COMMITTEE American College of Radiology Megan B. Marine, MD DRUGS AND CONTRAST MEDIA COMMITTEE; CO-CHAIR, CONTRAST MEDIA IN CHILDREN SUBCOMMITTEE American College of Radiology Monica Forbes-Amrhein, MD, PhD, FAAP
Perfusion MRI allows for brain tumor pathology and outcome prediction, and functional MRI maps brain structure and function for safer surgery.
Diagnostic Radiology Exam Volume: 2023 – 2024
2023
2024
10,844
12,145
CT
7,354
7,411
Fluoroscopy
Riley Children’s offers fellowships in pediatric radiology and pediatric neuroradiology .
DIRECTOR Matthew R. Wanner, MD, FACR, FAAP Associate Professor of Clinical Radiology and Imaging Sciences, IU School of Medicine > Connect with Dr. Wanner on Doximity.
10,804
11,609
MRI
896
861
Nuclear medicine
76,279
86,392
Radiographs
15 board certified physicians
See full team member list >
18,222
19,672
Ultrasound
124,399 138,090
TOTAL EXAMS
Annual Report 2024 – 2025
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