Riley Children's Health Annual Report – October 2025

CRITICAL CARE MEDICINE The 37-bed PICU at Riley Children’s Health provides skilled care to critically ill infants, children and adolescents. According to the Children’s Hospital Association, the PICU located at Riley Hospital for Children in downtown Indianapolis is one of the highest acuity centers in the United States. With all pediatric medical and surgical subspecialties represented, the PICU delivers a collaborative model for the care of a large volume of high-acuity diseases and injuries.

RESEARCH HIGHLIGHTS

NOTABLE PUBLICATIONS

■ 17 clinical trials and observational studies underway in critical care at Riley Children’s, including 11 funded by the National Institutes of Health, one funded by the U.S. Department of Defense and one funded by the Centers for Disease Control and Prevention Active in national and international studies focused on: ■ Hemodynamics changes in patients with severe malaria (Uganda) ■ Use of bubble CPAP in a pediatric teaching hospital (Liberia) ■ Biomarkers for respiratory failure in hematopoietic transplant patients ■ Use of respiratory support practices in PICUs across the U.S. (study conducted through the PICU Data Collaborative)

Nature: August 2024 Molecular mimicry in multisystem inflammatory syndrome in children Nature Medicine: July 2024 Pathobiological signatures of dysbiotic lung injury in pediatric patients undergoing stem cell transplantation Lancet (London, England): October 2024 RSV vaccine effectiveness against RSV-associated hospitalisations and emergency department encounters among adults aged 60 years and older in the USA Chest: November 2024 Framework for research gaps in pediatric ventilator liberation

Specialized programs Procedural Sedation Team ■ Facilitated 1,697 procedural sedations in 2024 ■ Only program in Indiana to offer nitrous oxide for moderate procedural sedation (112 completed in 2024) Advanced technologies ■ Etiometry ■ High-frequency oscillatory ventilation ■ Inhaled nitric oxide ■ Kinetic therapy rotational bed ■ Continuous renal replacement therapy (CRRT) ■ Aquapheresis

Committed to quality and safety

TOP DISTINCTIONS

■ Platinum Level ECMO Center of Excellence designated by the Extracorporeal Life Support Organization ■ Serves the critical care needs of Indiana’s largest pediatric trauma program

■ Reduced hospital-acquired harm The Riley PICU has significantly reduced the number of central line infections, pressure injuries and catheter-associated urinary tract infections. In 2024, our central line infection rate was 1.24 per 1,000 line days—lower than the national benchmark of 1.52. ■ CRRT support 60 patients were supported with CRRT in 2024. Additionally, the Riley PICU provided postoperative care for 20 children undergoing solid organ transplants. ■ Improved communication Nursing-integrated rounds and a standardized approach to communicating with families are being used to improve team collaboration and family experience during critical illness.

80 research publications in 2024

Professional organization affiliations CO-CHAIR, INTERNATIONAL COMMITTEE Pediatric Cardiac Intensive Society Adnan Bhutta, MD, FAAP, FCCM

■ The state’s only pediatric hospital with a dedicated burn ICU

MEMBER, AMERICAN HEART ASSOCIATION YOUNG HEARTS PEDIATRIC AND CONGENITAL CRITICAL CARE CARDIOLOGY COMMITTEE Council on Lifelong Congenital Heart Disease and Heart Health in the Young Adnan Bhutta, MD, FAAP, FCCM CHAIR, SPECIAL INTEREST GROUP ON GUIDELINES Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Samer M. Abu-Sultaneh, MD, FAAP, FCCM MEMBER, PREVENT SUBGROUP PALISI Samer M. Abu-Sultaneh, MD, FAAP, FCCM CHAIR, SCIENTIFIC OVERSIGHT COMMITTEE Extracorporeal Life Support Organization Matthew L. Friedman, MD CHAIR, HEMATOPOIETIC CELL TRANSPLANT, CANCER AND IMMUNOTHERAPY SUBGROUP PALISI Courtney M. Rowan, MD, MS MEMBER, SCIENTIFIC STEERING COMMITTEE PALISI Courtney M. Rowan, MD, MS CORE MEMBER PODIUM-Onc Initiative Courtney M. Rowan, MD, MS

OUR TEAM ALSO PUBLISHED IN: The Lancet Global Health The Journal of Pediatrics

■ Center of Excellence in Pediatric Sedation; designated by the Society for Pediatric Sedation ■ Serves as the medical control for the state’s largest pediatric critical care transport team

■ Indiana’s only pediatric critical care fellowship

3,168

2,872

2,752

DIVISION CHIEF Adnan Bhutta, MD, FAAP, FCCM Professor of Pediatrics, IU School of Medicine > Connect with Dr. Bhutta on Doximity.

2,425

Average daily census of 34.3

PICU Annual Admissions: 2021 – 2024

30 board certified physicians

See full team member list >

2021

2022

2023

2024

Annual Report 2024 – 2025

877.247.1177 IU Health 24/7 Transfer Center

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