Riley Children's Health Annual Report – October 2025

The maternal fetal medicine (MFM) specialists at Riley Children’s Health offer comprehensive high-risk pregnancy consultation for women with medical and obstetrical issues, including preexisting diabetes, chronic high blood pressure, preeclampsia, preterm labor and other complex medical conditions that affect pregnancy. MATERNAL FETAL MEDICINE

RESEARCH HIGHLIGHTS

Leading-edge diagnosis and treatment

Intensive glycemic targets in overweight and obese women with gestational diabetes mellitus: A multicenter randomized trial (iGDM trial) – National Institutes of Health-funded study evaluating the impact of standard versus intensive glucose targets in overweight/obese women with GDM at four clinical sites in the U.S. Gastroschisis Outcomes of Delivery (GOOD) study – Multicenter randomized clinical trial evaluating timing of delivery in pregnancies complicated by gastroschisis SERENE study -- Clinical trial designed to assess the safety and effectiveness of the KOKO device in treating primary abnormal postpartum uterine bleeding or hemorrhage Pregnancy data repository to assess management of Type 1 diabetes with diabetes technology (PRAM-T1D) -- Project to evaluate perinatal outcomes among individuals with Type 1 diabetes, accounting for the diabetes technology used for glucose management

■ Fetal surgery program, including laser treatment for twin-to-twin transfusion syndrome, insertion of bladder and chest shunts, therapy for amniotic band syndrome and myelomeningocele repair using mini- laparotomy/percutaneous fetoscopic approach ■ Transcervical and transabdominal cerclage for women with history of preterm birth ■ Percutaneous umbilical cord blood sampling and intrauterine transfusion for pregnancies impacted by anemia ■ Comprehensive care for women with cervical and cesarean scar ectopic pregnancies, including fertility- preserving options, if desired ■ Collaboration with gyn-oncology physicians to safely deliver women with placenta accreta spectrum

TOP DISTINCTIONS

Specialized programs

Fetal Center ■ Multidisciplinary counseling for

■ Largest group of MFM specialists in Indiana

pregnancies complicated by fetal health concerns diagnosed prior to delivery Diabetes in Pregnancy Program ■ Comprehensive care for women with diabetes, including management with

■ Partner in the Fetal Center at Riley Children’s Health , which supports management of high- risk or complex fetal conditions ■ One of the few health systems in the Midwest to offer laser treatment for twin-to-twin transfusion syndrome ■ Maternal Recovery Program provides opioid replacement therapy, counseling and group prenatal care ■ Education and training of four fellows through an ACGME- accredited maternal fetal medicine fellowship In 2025 Riley MFM specialists collaborated with pediatric neurosurgeons to perform Indiana’s first successful fetal repair of myelomeningocele. The team used a leading-edge, mini-laparotomy/percutaneous fetoscopic approach to complete the repair. > Learn more. The maternal fetal medicine ultrasound program at Riley Children’s is accredited by the Association for Medical Ultrasound .

continuous glucose monitoring and insulin pumps, and an on-site diabetes educator Maternal Cardiac Care Program ■ Collaboration with cardiologists to provide on-site care throughout pregnancy for maternal patients with cardiac disease Maternal Recovery Program ■ Social work, mental healthcare, counseling, opiate replacement therapy and continuity of care in the first year postpartum Renal Disease in Pregnancy Program ■ Collaboration with nephrologists to deliver specialized care for women with renal disease complicating pregnancy

NOTABLE PUBLICATIONS

American Journal of Obstetrics and Gynecology: October 2024 Intravenous immunoglobulin for the treatment of severe maternal alloimmunization: Individual patient data meta-analysis; Lead author: Hiba J. Mustafa, MD Diabetes Research and Clinical Practice: October 2024 Metabolic factors and perinatal outcomes among pregnant individuals with mild glucose intolerance; Lead author: Christina M. Scifres, MD American Journal of Obstetrics and Gynecology MFM: January 2024 Diagnostic performance of 32 vs 36 weeks ultrasound in predicting late-onset fetal growth restriction and small-for-

Maternal Fetal Medicine Volume: 2022 – 2024

New patient appointments 4,294

4,652

5,098

2022

2023

2024

All provider appointments 11,463

11,870

12,908

2022

2023

2024

DIVISION CHIEF Christina M. Scifres, MD Professor of Obstetrics and Gynecology, IU School of Medicine > Connect with Dr. Scifres on Doximity.

gestational-age neonates: A systematic review and meta-analysis; Lead author: Hiba J. Mustafa, MD Diabetes Care: August 2024 Continuous glucose monitoring in pregnancy: New insights into gestational diabetes with more to learn; Lead author: Christina M. Scifres, MD

Ultrasounds

9,603

10,049

10,664

2022

2023

2024

34 research publications in 2024

Genetic counseling encounters 1,674

15 board certified physicians

See full team member list >

1,654

1,594

2022

2023

2024

Annual Report 2024 – 2025

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