Riley Children's Health Annual Report – October 2025

Professional organization affiliations

PULMONOLOGY & SLEEP MEDICINE

RESEARCH HIGHLIGHTS

RANKED 9 TH IN THE NATION

Pulmonologists at Riley Children’s hold leadership positions in the following organizations: ■ International Council for Respiratory Care ■ American Thoracic Society Clinical Practice Guidelines Committee ■ American Thoracic Society Section of Genetics and Genomics Executive Committee ■ Cystic Fibrosis Foundation Clinical Research Committee ■ American Board of Pediatrics Credentialing Committee

■ Clinical trial to evaluate pharmacokinetics and safety of slow release dehydroepiandrosterone (Phase IIa) – Funded by the National Institutes of Health (NIH) ■ Obesity and childhood asthma: The role of adipose tissue – Funded by the NIH ■ Streamline treatment of pulmonary exacerbation in pediatrics (STOP PEDS RCT) ■ Personalized sup-tRNA approach for premature termination codon mutations in cystic fibrosis

Pulmonology and sleep medicine specialists at Riley Children’s Health provide advanced, child-focused and family-centered clinical care to children with respiratory and sleep disorders. Our

team serves as a specialized medical home that works together with hospital and community-based providers to treat children with chronic respiratory illnesses. Riley Pulmonology & Sleep Medicine provides services in seven locations across Indiana.

Premier programs

TOP DISTINCTIONS

Cystic Fibrosis Program With theratyping, Riley

Bronchopulmonary Dysplasia (BPD) Program A founding member of the BPD Collaborative, Riley Children’s delivers integrated inpatient/ outpatient BPD care to optimize transition to home and long- term outcomes with significant reduction in tracheostomies and post-NICU complications. > Learn more. Pulmonary Hypertension Program Fully integrated partnership between Riley pulmonology and cardiology provides expert, coordinated care for children with pulmonary hypertension as a primary diagnosis or resulting from another medical condition. Novel therapies and procedures Primary ciliary dyskinesia ■ High-speed video microscopy (HSVM) ■ Mucociliary clearance analysis (MCC) ■ Immunofluorescence microscopy (IFM) Cystic fibrosis ■ Nasal epithelial cell theratyping ■ Testing for response to CFTR modulators

■ One of the largest cystic fibrosis (CF) programs in the nation; one of the few pediatric centers in the U.S. that offers theratyping; only Indiana program accredited by the Cystic Fibrosis Foundation

NOTABLE PUBLICATIONS

Children’s helps patients gain access to highly effective CF transmembrane conductance regulator (CFTR) modulators. > Learn more. Our nationally recognized program also offers Trikafta® to mothers pregnant with a child with CF and a CF transition program for pediatric patients progressing to adult care. High-Risk Asthma Program Riley Children’s is a founding member of the Severe Pediatric Asthma Consortium. We are one of just three programs in the nation with a dedicated high-risk asthma psychologist. Nation’s longest- running severe asthma program Combining sleep medicine and psychology, the Hypersomnia Program, launched in 2023, treats patients with excessive daytime sleepiness and central hypersomnia.

JAMA Pediatrics: July 2024 Spirometry interpretation after implementation of race-neutral reference equations in children; Lead author: Erick Forno, MD, MPH JAMA Network Open: December 2024 Asthma among children with primary ciliary dyskinesia Senior author: Benjamin M. Gaston, MD Pediatric Pulmonology: January 2024 Assessment and management of anxiety and depression in a pediatric high-risk asthma clinic Annals of the American Thoracic Society: February 2025 Summary for clinicians: Clinical practice guideline for the detection of bronchiolitis obliterans syndrome after pediatric hematopoietic stem cell transplant; Lead author: Pi Chun Cheng, MD American Journal of Physiology-Lung Cellular and Molecular Physiology: April 2024 Antigen stasis and airway nitrosative stress in human primary ciliary dyskinesia; Lead author: Benjamin M. Gaston, MD Journal of Cystic Fibrosis: March 2024 Nasal airway inflammatory responses and pathogen detection in infants with cystic fibrosis; Senior author: Don B. Sanders, MD

■ Only facility in Indiana with pediatric sleep psychologists (Riley Children’s has four)

■ One of nine pediatric centers in the nation to be accredited as a Pulmonary Hypertension Center of Comprehensive Care

Asthma Readmission and Length of Stay (LOS): 2022 – 2024

30-day readmission rate

0.8% 2022

0.9% 2023

2.7% 2024

DIVISION CHIEF James F. Chmiel, MD, MPH, ATSF Professor of Pediatrics, IU School of Medicine > Connect with Dr. Chmiel on Doximity.

Median LOS

Program accreditations ■ Cystic Fibrosis Foundation

114 research publications in 2024

2 2022

1.5 2023

1.3 2024 LOS is 18% shorter than national average

■ American Academy of Sleep Medicine ■ Primary Ciliary Dyskinesia Foundation ■ Therapeutics Development Network ■ Pulmonary Hypertension Association

24 board certified physicians

See full team member list >

Annual Report 2024 – 2025

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