10. Test Methods • EIA Screening: (Enzyme Immunoassay)
8. Value Graph
Initial screening test using an antibodyantigen reaction to determine if a drug class is present in a sample. If a sample is negative for a drug class using EIA, then it is reported negative for that class and no further testing is conducted unless confirmation of negative is ordered. If it is positive, confirmation testing is performed by GC/MS or LC/MSMS. • GC/MS: GC/MS (Gas Chromatography with a Mass Spectrometry) This technique is used to separate drugs and metabolites (chromatography) and to uniquely identify them (mass spectrometry). This technique is considered the “gold standard” for detecting and quantifying drugs and their metabolites. • LC/MS/MS: LC/MS/MS Liquid Chromatography with Tandem Mass Spectrometry Technique used to separate drugs / metabolites while they are dissolved in a liquid. MS/MS, also called “tandem mass spectrometry” utilizes dual mass analyses of the drug / metabolite, which is more speci c than single MS. Drugs / Metabolites can be quantified at extremely low concentrations.
Graph of inconsistent result values for up to the last five reports.
9. Detailed Results • Test Name
Class & Specific Metabolites. • Test Result Positive or negative for class or metabolite. • Report Value Amount of drug or metabolite detected in ng/mL • Cut Off Level If 1 value appears, the number represents the confirmation level (LC/MS/MS or GC/MS) If 2 values appear, the 1st number represents the screen level (EIA), and the 2nd number represents the confirmation level (LC/MS/MS or GC/MS) or GC/MS). • Determination Will be reported as “Consistent” or “Inconsistent” with expected medication / drug list. • Note Notes that help further explain results will appear in this section of the report. If illicit drugs or prescribed medications are detected it will be noted here. This section will also provide an explanation of inconsistent results.
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11. Validity Testing • Speci c Gravity & Creatinine - A urine specimen is considered dilute when: speci c gravity falls between 1.0010 and 1.0030 and creatinine is less than 20 mg/d. This is a signal that the concentration of the urine is very weak. This can be caused by: Increased uid intake (intentional), or, presence of a serious disease state. Increased uid intake also reduces concentration of excreted material in urine. A decrease in the concentrated material may in uence the outcome of a drug test. Diuretics (such as Lasix) may also lower creatinine levels within six hours of ingestion.
Note: Not all reports contain all of these elements.
Note: Not all reports contain all of these elements.
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