Advancing Equine Health Through Genetic and Environmental Research
By: Elaine Norton & Mindy Burnett
primary research project involves investigating the GxE interactions contributing to EMS using a multi-omics approach—incorporating genetics, transcriptomics, metabolomics, and epigenetics. This comprehensive method will provide new insights into the environmental triggers that interact with genetic factors to manifest EMS clinical symptoms. Dr. Norton highlights the broader implications of this research. “EMS in horses is remarkably similar to metabolic syndrome in humans, which is a risk factor for diseases such as heart disease and type 2 diabetes,” she explains. Metabolic syndrome affects one in three adults in the US, and while genetics play a role, the complexity of environmental factors can obscure clear treatment pathways. Because horses serve as naturally occurring models for metabolic diseases, studying EMS could help overcome challenges encountered in human research and could have significant implications for improving human health. Exploring Maternal EMS and Its Impact on Foal Health In collaboration with Dr. Jane Manfredi at Michigan State University and funded by the Grayson Jockey Club, Dr. Norton is also investigating the effects of maternal EMS on foal health. With an increasing number of
Dr. Elaine Norton, an assistant professor at the University of Arizona College of Veterinary Medicine, has made it her mission to bridge the gap between human and animal welfare by studying complex genetic traits in horses. Her work on equine metabolic syndrome (EMS) aims to transform the equine industry and contribute valuable insights into human health. Equine metabolic syndrome is a significant health issue due to its role in causing laminitis, a painful hoof condition leading to costly medical treatments and, often, euthanasia. This syndrome affects a significant portion of high-risk horse populations. Yet, disease management regimens remain highly focused on generalized diet and exercise protocols that may fail to address the individual needs of affected animals. “The lack of understanding of the complex relationship between genetics and environmental factors is a barrier to effective treatment,” says Dr. Norton. Her research strives to uncover the gene-environment interactions (GxE) that influence EMS, offering the potential for more personalized management plans that could improve treatment outcomes and prevent laminitis. Unveiling Gene-Environment Interactions in Equine Metabolic Syndrome Funded by the USDA-NIFA, Dr. Norton’s
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