RNSH DIVISION OF SURGERY & ANAESTHESIA
RESEARCH ACTIVITY REPORT 2021 - 2022
AUTHOR: RNSH SERT INSTITUTE
Acknowledgements: A special thanks to all surgeons across RNSH departments who generously provided information and feedback during the development of this document. Their willingness to share this information has contributed to the quality and richness of this publication. Further information: Surgical Education Research & Training Institute Royal North Shore Hospital St Leonards NSW 2065 Australia Wide distribution of this document is encouraged. This work is copyrighted. It may be reproduced in whole or in part for study or training purposes subject to the inclusion of an acknowledgement of the source. It may not be reproduced for commercial usage or sale. Reproduction for purposes other than those indicated above requires written permission from the Surgical Education Research & Training Institute.
Published September 2023
EXECUTIVE SUMMARY
This report provides a comprehensive overview of the research activity undertaken by clinicians in the Division of Surgery and Anaesthesia (DoSA) at Royal North Shore Hospital (RNSH) for 2021 to 2022. This is a follow-up from the inaugural research report published in 2020 which documented the research output of all surgical departments. Following consultation with the DoSA, we have expanded the coverage of the report to encompass the Anaesthesia Department (including Allergy Clinic and Acute Pain Management), Intensive Care Unit and the Trauma Service. At the centre of every clinician's work is a commitment to enhancing care in pursuit of optimal patient outcomes. Within the DoSA, research includes the exploration of novel medical and surgical methodologies and techniques, collaborative translational investigations, and the improvement of existing practices through rigorous data analysis and clinical audits. The approach used to produce this report involved a systematic search of peer-reviewed publications authored by RNSH clinicians followed by direct correspondence with the Heads of Departments and Academic Leads to ensure completeness. Each department was also asked to provide additional details regarding current research activities, including involvement with laboratory-based projects and or supervision of higher degree research. This report highlights the significant volume of research activity and peer-reviewed publications within the DoSA throughout 2021-2022. During this period, a total of 590 manuscripts were published, averaging 295 publications per year. Several departments have also demonstrated a strong focus on translational research, maintaining close affiliations with laboratories within the Kolling Building and external to RNSH, as well as collaborations with local and international universities. The Research Activity Report is a dynamic document and will be updated annually to reflect new research activity and publications.
I hope you enjoy this report and uncovering some of the remarkable research achievements undertaken at RNSH.
Professor Thomas Hugh Director, Surgical Education Research & Training Institute
CONTENTS
Anaesthesia
page 1
Acute Surgical Unit
page 4
Breast & Melanoma Surgery
page 5
Burns, Plastics & Reconstructive Surgery
page 8
Cardiothoracic Surgery
page 10
Colorectal Surgery
page 12
Endocrine Surgery
page 15
Hand & Peripheral Nerve Surgery
page 18
Intensive Care Unit
page 21
Neurosurgery
page 27
Neurointervention Unit
page 29
Ophthalmology
page 31
Orthopaedic Surgery
page 35
Otolaryngology Head & Neck Surgery
page 41
Trauma Service
page 44
Upper Gastrointestinal Surgery
page 47
Urological Surgery
page 53
Vascular Surgery
page 57
ANAESTHESIA (INCLUDES: ALLERGY CLINIC AND ACUTE PAIN MANAGEMENT) Head of Department: Ben Olesnicky and Jonothon Brock
DEPARTMENTAL RESEARCH RESOURCES
CLINICAL DATABASES TO SUPPORT OUTCOMES RESEARCH • Allergy/Australian and New Zealand Anaesthetic Allergy Group • Trauma • Perioperative Medicine • Perioperative Allergy Database
CURRENT NSLHD HUMAN RESEARCH ETHICS APPLICATION (HREA) APPROVALS • Validation of a scoring tool for suspected peri-operative immediate hypersensitivity reactions using case referrals to Royal North Shore peri-operative Allergy Clinic • Skin testing - in vitro testing and drug provocation testing for diagnosis and management of drug allergy LINKS TO TRANSLATIONAL RESEARCH PARTNERS OR UNIVERSITY DEPARTMENTS • Department of Immunology • Australian and New Zealand Anaesthetic Allergy Group (ANZAAG)
CURRENT RESEARCH ACTIVITY
Clinical Trials • Chewy - chewing gum versus ondansetron for post-operative nausea and vomiting in women and girls having laparoscopic or breast surgery • MASTERSTROKE - Management of Systolic blood pressure during Thrombectomy by Endovascular route for acute ischaemic STROKE • Investigation of massive transfusion practice and development of an experimental clinical decision support system • The feasibility of implementing a validated fatigue risk management system for Junior Medical Staff on nightshift • Long-term Outcomes of Lidocaine Infusions for PostOperative Pain (LOLIPOP) • Orthostatic hypotension in the post anaesthesia care unit as a predictor for delayed mobilisation post lower limb arthroplasty • Validation of a scoring tool for suspected peri-operative immediate hypersensitivity reactions using case referrals to Royal North Shore peri-operative Allergy Clinic • Perioperative analgesia for major abdominal surgery • Opioid neuraxial analgesia for major open abdominal surgery: a feasibility study using a combination of intrathecal and epidural morphine • Rib fracture intervention study
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Clinical Research • Perioperative anaphylaxis validation study • PICC line service utilisation database • Code crimson activation and outcomes study • Acute rib fracture management study • Linking data between perioperative drug allergy services in the ANZAAG network • Development of cost-efficient and effective intravenous drug challenge protocols in perioperative drug allergy • Drug test dose and desensitisation protocol development using a proportional delivery syringe driver system • Assessment of maximal non-irritant concentrations of cisatracurium in intradermal drug allergy testing • Evaluation of clinical scoring tools to assist diagnosis and triage in perioperative allergy • Penicillin allergy de-labelling in the pre-operative period • Linking tryptase levels to drug reaction severity
PUBLICATIONS
2022
Magee et al. 2022 “A Digital Video and Text Messaging Intervention to Support People With Chronic Pain During Opioid Tapering: Content Development Using Co-design.” JMIR Form Res 6: e40507 PMID:36355415 Surgical Staff: Paul Glare Koneru et al. 2022 “Patient-controlled analgesia and oral mucositis pain in hematological malignancies.” J Opioid Manag 18: 309-316 PMID:36052929 Surgical Staff: Matthew Doane, Gavin Pattullo, Ross MacPherson Olesnicky et al. 2022 “Prevention of Postoperative Events following Reversal with Sugammadex or Neostigmine (the P-PERSoN Trial): Pilot Data Following Early Termination of a Prospective, Blinded, Randomised Trial.” Anesthesiol Res Pract 2022: 4659795 PMID:35844810 Surgical Staff: Ben Olesnicky, Matthew Doane Pirie et al. 2022 “Current approaches to acute postoperative pain management after major abdominal surgery: a narrative review and future directions.” Br J Anaesth 129: 378-393 PMID:35803751 Surgical Staff: Damien Finniss Hayashi et al. 2022 “A Systematic Review of the Variation in Pain Catastrophizing Scale Reference Scores Based on Language Version and Country in Patients with Chronic Primary (Non-specific) Pain.” Pain Ther 11: 753-769 PMID:35567720 Surgical Staff: Paul Wrigley Magee et al. 2022 “Evaluating acceptability and feasibility of a mobile health intervention to improve self-efficacy in prescription opioid tapering in patients with chronic pain: protocol for a pilot randomised, single-blind, controlled trial.” BMJ Open 12: e057174 PMID:35473742 Surgical Staff: Paul Glare Baldo et al. 2022 “Mechanisms of opioid-induced respiratory depression.” Arch Toxicol 96: 2247-2260 PMID:35471232 Surgical Staff: Michael Rose Tran et al. 2022 “An Exploratory EEG Analysis on the Effects of Virtual Reality in People with Neuropathic Pain Following Spinal Cord Injury.” Sensors (Basel) 22: 2629 PMID:35408245 Surgical Staff: Paul Wrigley Avery et al. 2022 “Efficacy of interventions to reduce long term opioid treatment for chronic non-cancer pain: systematic review and meta-analysis.” BMJ 377: e066375 PMID:35379650 Surgical Staff: Rebecca Martin, Paul Glare Glare et al. 2022 “Pharmacologic Management of Persistent Pain in Cancer Survivors.” Drugs 82: 275-291 PMID:35175587 Surgical Staff: Paul Glare Thind et al. 2022 “Whole genome analysis reveals the genomic complexity in metastatic cutaneous squamous cell carcinoma.” Front Oncol 12: 919118 PMID:35982973 Surgical Staff: Ajaypal Thind Pirie et al. 2022 “Analgesia for major laparoscopic abdominal surgery: a randomised feasibility trial using intrathecal morphine.” Anaesthesia 77: 428-437 PMID:35038165 Surgical Staff: Matthew Doane Olesnicky et al. 2022 “The use of sugammadex in critical events in anaesthesia: A retrospective review of the webAIRS database.” Anaesth Intensive Care 50: 220-226 PMID:35172631 Surgical Staff: Ben Olesnicky Collantes, et al. 2022 “Essential Notes in Pain Medicine.” Oxford University Press Print ISBN: 9780198799443 Surgical Staff: Enrique Collantes Celador Corcoran TB et al 2022 “Dexamethasone and Surgical-Site Infection” NEJM 384: 1731-1741 PMID:33951362 Surgical Staff: Ben Olesnicky
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Pattullo 2022 “Opioids in acute pain: Towards getting the right balance” Anaesthesia & Intensive Care 50: 68-80 PMID:35112598 Surgical Staff: Gavin Pattullo Pattullo 2022 “Clinical implications of opioid-induced ventilatory impairment” Anaesthesia & Intensive Care 50: 52-67 PMID:35189729 Surgical Staff: Gavin Pattullo
2021
Benness et al. 2021 “Selection of prize session abstracts presented at the 2021 Virtual Australian and New Zealand College of Anaesthetists Annual Scientific Meeting, April 27–May 4 2021, Melbourne, Australia” Anaesth Intensive Care : 1-16 PMID:34878927 Surgical Staff: Matthew Doane Dutta et al. 2021 “Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community.” ESC Heart Fail 8: 5392-5402 PMID:34657379 Surgical Staff: Andy Wang Eastwood et al. 2021 “Psychosocial stratification of antenatal indicators to guide population-based programs in perinatal depression.” BMC Pregnancy and Childbirth 21: 277 PMID:33823838 Surgical Staff: Andy Wang Evers et al. 2021 “What Should Clinicians Tell Patients about Placebo and Nocebo Effects? Practical Considerations Based on Expert Consensus.” Psychotherapy and Psychosomatics 90: 49-56 PMID:33075796 Surgical Staff: Damien Finniss Fernando et al. 2021 “Pharmacovigilance for chlorhexidine anaphylaxis: a preventable adverse reaction” Med J Aust 214: 162-163 PMID:33527357 Surgical Staff: Mark Capon, Sarah Green Prisim Trial Group 2021 “Postoperative continuous positive airway pressure to prevent pneumonia, re-intubation, and death after major abdominal surgery (PRISM): a multicentre, open-label, randomised, phase 3 trial” Lancet Respi Med 9: 1221- 1230 PMID:34153272 Surgical Staff: Katrina Pirie Menon et al. 2021 “Has the reporting of patient-important outcomes improved in surgical trials? A meta-epidemiological study.” ANZ J Surg 91: 2014-2020 PMID:33982387 Surgical Staff: Andy Wang Olesnicky et al. 2021 “A survey of current management of neuromuscular block and reversal in Australia and New Zealand” Anaesth Intensive Care 49: 309-315 PMID:34372679 Surgical Staff: Ben Olesnicky Qurashi et al. 2021 “Overnight or Short Stay Joint Replacements in the Public and Private settings: An Australian Experience.” Reconstructive Review : Surgical Staff: Bill Bestic Rogers et al. 2021 “Teaching medical students during clinical anaesthesia placements: Australian and New Zealand College of Anaesthetists, 2021.” Australiasian Anaesthesia : Surgical Staff: Ross MacPherson Schmid et al. 2021 “Two case studies of cardiac arrest occurring in medically fit patients undergoing radical hysterectomy for cervical cancer” Gynecol Oncol Rep 37: 100823 PMID:34377756 Surgical Staff: Leonie Watterson Van Zundert et al. 2021 “2021 Update on airway management from the Anaesthesia Continuing Education Airway Management Special Interest Group” Anaesthesia & Intensive Care 49: 257-267 PMID:34154374 Surgical Staff: Geraldine Khong, Adam Rehak
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ACUTE SURGICAL UNIT Head of Department: Rebecca Seton
DEPARTMENTAL RESEARCH RESOURCES
CLINICAL DATABASES TO SUPPORT OUTCOMES RESEARCH • Acute Surgical Unit Database • Acute Surgical Unit QoR 15 • Acute Surgical Unit Impact Cohort • Acute Surgical Unit Patient Management Work Instructions
CURRENT NSLHD HUMAN RESEARCH ETHICS APPLICATION (HREA) APPROVALS • STE15169 – Evaluating the use of the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) - surgical risk calculator in predicting mortality in an Acute Surgical Unit and how it has assisted in the management of patients deemed to be at high risk of post-operative mortality • STE16869 – American College of Surgeons National Surgical Quality Improvement Program - comparison between NSQIP risk calculator and NSQIP adult with aim of determining accuracy of risk calculator in the Australian population in emergency surgery
CURRENT RESEARCH ACTIVITY
• Comparison between NSQIP risk calculator and NSQIP adult with aim of determining accuracy of risk calculator in the Australian population in emergency surgery • Adhesional SBO management • COVID-19 testing using antibody test kits • ASU anti-microbial stewardship
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BREAST AND MELANOMA SURGERY Head of Department: Katrina Moore
RESEARCH SUPERVISION (2021-2022)
Katrina Moore •
Senior Lecturer, University of Sydney
Education and Teaching Modules: • Supervisor, Medical Student Program – Oncology Block, University of Sydney • Supervisor, Accredited Registrar Training Program, University of Sydney
Samitri Sood •
Master of Surgery, University of Sydney
Education and Teaching Modules: • Teaching and Course Coordinator, Advanced Surgery of the Breast - Master of Surgery, University of Sydney
Andrew Spillane •
Master of Surgery, University of Sydney
Education and Teaching Modules: • Teaching and Head of Course, Advanced Surgery of the Breast - Master of Surgery, University of Sydney
DEPARTMENTAL RESEARCH RESOURCES
CLINICAL DATABASES TO SUPPORT OUTCOMES RESEARCH • Breast High Risk Database • Breast Total Practice Audit • BreastSurgANZ Quality Audit (BQA) • Melanoma Research Database (MRD) - Melanoma Institute Australia
CURRENT NSLHD HUMAN RESEARCH ETHICS APPLICATION (HREA) APPROVALS • EXPERT Study • WinPRO Study • iBREAST Study • QoLID Study • BRCAP Study LINKS TO TRANSLATIONAL RESEARCH PARTNERS OR UNIVERSITY DEPARTMENTS • Melanoma Institute Australia • University of Sydney – Discipline of Surgery • Kolling Research Institute
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CURRENT RESEARCH ACTIVITY
• Clinical and laboratory-based research in melanoma and breast cancer • Retrospective study on loco-regional recurrence and functional outcomes following axillary treatment in early node positive breast cancer • Outcomes of targeted axillary clearance in early node positive breast cancer following neoadjuvant chemotherapy • Breast screening in patients with neurofibromatosis • Staging investigations in high-risk patients and their subsequent follow-up • Development of a multidisciplinary and functional breast database for northern campus
PUBLICATIONS
2022
Dempsey et al. 2022 “Embedding electronic patient-reported outcome measures into routine care for patients with stage III MELanoma (ePROMs-MEL): protocol for a prospective, longitudinal, mixed-methods pilot study.” BMJ Open 12: e066852 PMID:36600423 Surgical Staff: Andrew Spillane Winder et al. 2022 “Radio-isotope occult lesion localization (ROLL) techniques to identify the clipped node for targeted axillary dissection (TAD) in breast cancer.” ANZ J Surg 92: 3017-3021 PMID:36262092 Surgical Staff: Andrew Spillane, Samriti Sood, Kylie Snook Smith et al. 2022 “Factors influencing acceptance, adoption and adherence to sentinel node biopsy recommendations in the Australian Melanoma Management Guidelines: a qualitative study using an implementation science framework.” Implement Sci Commun 3: 103 PMID:36183121 Surgical Staff: Andrew Spillane Simpson et al. 2022 “Diet-driven microbial ecology underpins associations between cancer immunotherapy outcomes and the gut microbiome.” Nat Med 28: 2344-2352 PMID:36138151 Surgical Staff: Andrew Spillane Newell et al. 2022 “Comparative Genomics Provides Etiologic and Biological Insight into Melanoma Subtypes.” Cancer Discov 12: 2856-2879 PMID:36098958 Surgical Staff: Andrew Spillane Conway et al. 2022 “Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites.” J Immunother Cancer 10: e004884 PMID:36096531 Surgical Staff: Andrew Spillane Seviiri et al. 2022 “Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting.” J Transl Med 20: 403 PMID:36064556 Surgical Staff: Andrew Spillane Lawless et al. 2022 “ASO Visual Abstract: Clinicopathological Characteristics Predicting Further Recurrence and Survival Following Resection of In-transit Melanoma Metastases.” Ann Surg Oncol 29: 7031-7032 PMID:35994160 Surgical Staff: Andrew Spillane Ofri et al. 2022 “Synchronous Operable Pancreatic and Breast Cancer Without Genetic Mutation: A Literature Review and Discussion.” Front Surg 9: 858349 PMID:35813042 Surgical Staff: Samriti Sood, Jaswinder Samra, Anubhav Mittal Lawless et al. 2022 “Clinicopathological Characteristics Predicting Further Recurrence and Survival Following Resection of In-Transit Melanoma Metastases.” Ann Surg Oncol 29: 7019-7028 PMID:35771368 Surgical Staff: Andrew Spillane Reijers et al. 2022 “Personalized response-directed surgery and adjuvant therapy after neoadjuvant ipilimumab and nivolumab in high-risk stage III melanoma: the PRADO trial.” Nat Med 28: 1178-1188 PMID:35661157 Surgical Staff: Andrew Spillane van Akkooi et al. 2022 “Correction to: Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC).” Ann Surg Oncol 29: 5241-5242 PMID:35426590 Surgical Staff: Andrew Spillane Metz et al. 2022 “Breast Radiotherapy after Oncoplastic Surgery-A Multidisciplinary Approach.” Cancers (Basel) 14: 1685 PMID:35406457 Surgical Staff: Kylie Snook, Samriti Sood, Andrew Spillane El Sharouni et al. 2022 “Time interval between diagnostic excision-biopsy of a primary melanoma and sentinel node biopsy: effects on the sentinel node positivity rate and survival outcomes.” Eur J Cancer 167: 123-132 PMID:35256245 Surgical Staff: Andrew Spillane El Sharouni et al. 2022 “Effect of the time interval between melanoma diagnosis and sentinel node biopsy on the size of metastatic tumour deposits in node-positive patients.” Eur J Cancer 167: 133-141 PMID:35216870 Surgical Staff: Andrew Spillane
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Reijers et al. 2022 “Representativeness of the Index Lymph Node for Total Nodal Basin in Pathologic Response Assessment After Neoadjuvant Checkpoint Inhibitor Therapy in Patients With Stage III Melanoma.” JAMA Surg 157: 335-342 PMID:35138335 Surgical Staff: Andrew Spillane van Akkooi et al. 2022 “Neoadjuvant Systemic Therapy (NAST) in Patients with Melanoma: Surgical Considerations by the International Neoadjuvant Melanoma Consortium (INMC).” Ann Surg Oncol 29: 3694-3708 PMID:35089452 Surgical Staff: Andrew Spillane Newell et al. 2022 “Multiomic profiling of checkpoint inhibitor-treated melanoma: Identifying predictors of response and resistance, and markers of biological discordance.” Cancer Cell 40: 88-102.e7 PMID:34951955 Surgical Staff: Andrew Spillane Scolyer et al. 2022 “BRAF mutation testing for patients diagnosed with stage III or stage IV melanoma: practical guidance for the Australian setting.” Pathology 54: 6-19 PMID:34937664 Surgical Staff: Andrew Spillane Liyanage et al. 2022 “Multi-Trait Genetic Analysis Identifies Autoimmune Loci Associated with Cutaneous Melanoma.” J Invest Dermatol 142: 1607-1616 PMID:34813871 Surgical Staff: Andrew Spillane Dempsey et al. 2022 “The role of breast reconstruction choice on body image patient-reported outcomes at four years post-mastectomy for breast cancer: A longitudinal prospective cohort study.” Psychooncology 31: 54-61 PMID:34498358 Surgical Staff: Kylie Snook, Andrew Spillane Crook et al. 2022 “The psychological impact and experience of breast cancer screening in young women with an increased risk of breast cancer due to neurofibromatosis type 1.” Fam Cancer 21: 241-253 PMID:33963463 Surgical Staff: Katrina Moore
2021
Downs et al. 2021 “A survey of surgical management of the sentinel node positive melanoma patient in the post-MSLT2 era.” J Surg Oncol 124: 1544-1550 PMID:34406652 Surgical Staff: Andrew Spillane Aivazian et al. 2021 “Correction to: Histological regression in melanoma: impact on sentinel lymph node status and survival.” Mod Pathol 34: 2091 PMID:34349230 Surgical Staff: Andrew Spillane Li et al. 2021 “Survival Outcomes of Salvage Metastasectomy After Failure of Modern-Era Systemic Therapy for Melanoma.” Ann Surg Oncol 28: 6109-6123 PMID:34347220 Surgical Staff: Andrew Spillane Aivazian et al. 2021 “Histological regression in melanoma: impact on sentinel lymph node status and survival.” Mod Pathol 34: 1999-2008 PMID:34247192 Surgical Staff: Andrew Spillane Ch'ng et al. 2021 “Re-defining the role of surgery in the management of patients with oligometastatic stage IV melanoma in the era of effective systemic therapies.” Eur J Cancer 153: 8-15 PMID:34126335 Surgical Staff: Andrew Spillane Rawson et al. 2021 “Pathological response and tumour bed histopathological features correlate with survival following neoadjuvant immunotherapy in stage III melanoma.” Ann Oncol 32: 766-777 PMID:33744385 Surgical Staff: Andrew Spillane Thompson et al. 2021 “Treatment of in-transit melanoma metastases using intralesional PV-10.” Melanoma Res 31: 232-241 PMID:33741814 Surgical Staff: Andrew Spillane Menzies et al. 2021 “Pathological response and survival with neoadjuvant therapy in melanoma: a pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC).” Nat Med 27: 301-309 PMID:33558722 Surgical Staff: Andrew Spillane Rozeman et al. 2021 “Survival and biomarker analyses from the OpACIN-neo and OpACIN neoadjuvant immunotherapy trials in stage III melanoma.” Nat Med 27: 256-263 PMID:33558721 Surgical Staff: Andrew Spillane Abd El-Aziz et al. 2021 “Role of ABCB1 in mediating chemoresistance of triple-negative breast cancers.” Biosci Rep 41: 2 PMID:33543229 Surgical Staff: Andrew Spillane Maw et al. 2021 “Case Report of 18F-FDG PET/CT Features of Polyacrylamide Hydrogel Mammoplasty.” Clin Nucl Med 46: e206-e207 PMID:33208622 Surgical Staff: Samriti Sood
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BURNS, PLASTICS & RECONSTRUCTIVE SURGERY Head of Department: Rowan Gillies
RESEARCH SUPERVISION (2021-2022)
Varun Harish • Supervisor, MD Program, University of Sydney • Supervisor, Master of Surgery, University of Sydney • Supervisor, MD Applied Research Project, University of Notre Dame
DEPARTMENTAL RESEARCH RESOURCES
CLINICAL DATABASES TO SUPPORT OUTCOMES RESEARCH • State-wide Burn Injury Service (SBIS) Registry • Burns Registry Australia & New Zealand (BRANZ) • Plastic Surgery Department REDCap Database
CURRENT NSLHD HUMAN RESEARCH ETHICS APPLICATION (HREA) APPROVALS • Skin neoplasia – clinical and pathologic aspects in diagnosis and management of skin tumours in the Australian population • Hypothermia in burn injuries • The effect of indocyanine green video angiography on short-term and long-term clinical outcomes in burn injuries: a randomised controlled trial
CURRENT RESEARCH ACTIVITY
• Pleomorphic dermal sarcoma: the effect of surgical and histological margins on clinical outcomes • Histological margin clearance in cutaneous squamous cell carcinoma • Cost-benefit analysis of Novosorb BTM in burn injuries • The impact of core body temperature on clinical outcomes in severe burn injuries • Treatment of atypical lipomatous tumours: a systematic review
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PUBLICATIONS
2022
Soliman et al. 2022 “Laparoscopic-assisted deep inferior epigastric artery perforator (DIEP) flap in breast reconstruction.” ANZ J Surg 92: 2365-2367 PMID:35075753 Surgical Staff: Bishoy Soliman, Varun Harish Jung et al. 2022 “Management strategies for perioperative anaemia in the severely burn-injured Jehovah’s Witness patients who decline a blood transfusion.” Burns: Journal of the International Society for Burn Injuries 49 :716-729 PMID: 35941026 Surgical Staff: Varun Harish, Rowan Gillies Haines et al. 2022 “The burn injury transfer feedback form: A 16-year Australian statewide review of burn inter-hospital transfer.” Burns: Journal of the International Society for Burn Injuries 49 : 961-972 PMID: 35728985 Surgical Staff: Bishoy Soliman, Shane O’Neill, Jeon Cha, John Vandervord, Varun Harish Wright et al. 2022 “Suprafascial first dorsal metatarsal artery perforator propeller flap” Australasian Journal of Plastic Surgery 5 : 74-76 Surgical Staff: Varun Harish
2021
Haines et al. 2021 “Treating the burnt auricle using Biobrane.” ANZ J Surg 91: 453-454 PMID:33740300 Surgical Staff: Jeon Cha Cubitt et al. 2021 “Mandibular distraction osteogenesis for Pierre Robin sequence: The Sydney experience.” J Plast Reconstr Aesthet Surg 74: 890-930 PMID:33162386 Surgical Staff: Robert Gates Aggarwala et al. 2021 “Treatment of Partial Thickness Burns: A Prospective, Randomized Controlled Trial Comparing Four Routinely Used Burns Dressings in an Ambulatory Care Setting.” J Burn Care Res 42: 934-943 PMID:32930784 Surgical Staff: Varun Harish
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CARDIOTHORACIC SURGERY Head of Department: Michael Harden
DEPARTMENTAL RESEARCH RESOURCES
CLINICAL DATABASES TO SUPPORT OUTCOMES RESEARCH • Australian & New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) National Database • RNSH Cardiovascular Surgery Database • Implantable Cardiac Device Database CURRENT NSLHD HUMAN RESEARCH ETHICS APPLICATION (HREA) APPROVALS • A randomised control trial of axillary artery cannulation versus standard aortic cannulation for aortic valve replacement • 2019/ETH12555: A study of flow dynamics in Coronary Artery Bypass Grafts developing a model to predict the flow based on which conduit, coronary distribution, and graft configuration
CURRENT RESEARCH ACTIVITY
• Enhanced Recovery After Surgery (ERAS) protocol - collaborative project to optimise perioperative care of cardiac surgical patients • AI tool development for predicting cardiothoracic ward patients that are likely to deteriorate (with Sydney Adventist Hospital) • Development of a RNSH implantable cardiac device database to record all cases performed • Long term follow up (10-15 years) of off-pump arterial grafts and projects related to assessing and improving off-pump surgery • Bio-printing of human cardiac patches to improve heart regeneration • Evaluating use of aortic cannulation in valve replacement • Investigating axillary inflow cerebral injury in patients undergoing aortic valve replacement • Vascular leak associated micro-RNA in cardiovascular surgery • Determining trans-catheter aortic valve implantation outcomes in low-risk patients
PUBLICATIONS
Manuel et al. 2022 “LIMA to LAD grafting returns patient survival to age-matched population: 20-year outcomes of MIDCAB surgery.” Interact Cardiovasc Thorac Surg 35: 4 PMID:36130278 Surgical Staff: Levi Bassin Khuong et al. 2022 “Paraprotein associated heparin resistance during cardiopulmonary bypass.” Perfusion 38 :1319-1321 PMID:35700111 Surgical Staff: Levi Bassin Porwal et al. 2022 “Atypical Presentation of Acute Mitral Regurgitation Secondary to Papillary Muscle Rupture.” Cureus 14: e24744 PMID:35676997 Surgical Staff: Manu Mathur Caterson et al. 2022 “Post-operative outcomes of inflammatory thoracic aortitis: a study of 41 patients from a cohort of 1119 surgical cases.” Clin Rheumatol 41: 1219-1226 PMID:34731347 Surgical Staff: David Marshman 2022
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2021
Gunawan et al. 2021 “In patients with lung cancer is combined endobronchial ultrasound and endoscopic ultrasound superior to conventional mediastinoscopy in staging the mediastinum?” Ann Med Surg (Lond) 71: 102953 PMID:34712479 Surgical Staff: Levi Bassin Bell et al. 2021 “A Trend-Based Early Warning Score Can Be Implemented in a Hospital Electronic Medical Record to Effectively Predict Inpatient Deterioration.” Crit Care Med 49: e961-e967 PMID:33935165 Surgical Staff: Levi Bassin Allahwala et al. 2021 “Both surgical and percutaneous revascularization improve prognosis in patients with a coronary chronic total occlusion (CTO) irrespective of collateral robustness.” Heart Vessels 36: 1653-1660 PMID:33914092 Surgical Staff: Levi Bassin Cullen et al. 2021 “Post-Dissection Single-Stage Arch and Descending Aorta Replacement via Clamshell Incision.” Heart Lung Circ 30: e68-e71 PMID:33589400 Surgical Staff: Manu Mathur Chen et al. 2021 “Salvage thoracotomy for atraumatic tension haemothorax in a patient with neurofibromatosis type 1: an Australian experience.” ANZ J Surg 91: E419-E420 PMID:33236494 Surgical Staff: Levi Bassin Manuel et al. 2021 “Robotic approach to the porcelain aorta: staged transcatheter aortic valve replacement and robotically assisted coronary artery bypass.” ANZ J Surg 91: E128-E129 PMID:33107164 Surgical Staff: Levi Bassin
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COLORECTAL SURGERY Head of Department: Alexander Engel
RESEARCH SUPERVISION (2021-2022)
Alexander Engel •
3 PhD Students 2 Master Students
• •
4 MD Research Students
Margaret Schnitzler • 3 PhD Students
Education and Teaching Modules: • Co-Director of MD Education Specialty of Surgery
DEPARTMENTAL RESEARCH RESOURCES
CLINICAL DATABASES TO SUPPORT OUTCOMES RESEARCH • RNSH Colorectal Audit • Bi-National Colorectal Cancer Audit (BCCA) • Colorectal Cancer Surgical Pathology Database • IMAP Colorectal Polyp Study • Diverticulitis Recurrence • Diverticulosis/-itis CT Diagnosed • PR Bleeding
CURRENT NSLHD HUMAN RESEARCH ETHICS APPLICATION (HREA) APPROVALS • ETH08162 - Analysis of patients presenting with haematochezia/PR bleeding at a single centre • ETH01264 - CT and clinical correlation of diverticulitis severity • ETH00301 - IMAP Study - Integrative Molecular Analysis of Polyps • HREC/17/RPAH/542 - Hide and Seek: MDT advice and subsequent genetic counselling for suspected Lynch syndrome LINKS TO TRANSLATIONAL RESEARCH PARTNERS OR UNIVERSITY DEPARTMENTS • University of Sydney Nano Institute • University of Sydney Charles Perkins Centre • University of NSW Nano Photonics Institute
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CURRENT RESEARCH ACTIVITY
• Outcome of primary repair of obstetric sphincter rupture • Classification of intra-operative complications • Nanotechnology and improvement in diagnosis and management of CRC lymph node metastasis • Photodynamic therapy in combination with low dose radiotherapy as an alternative to chemoradiation in advanced and recurrent rectal cancer • Integrative molecular classification of colorectal polyps • Molecular signature of lymph node metastasis in early colorectal cancer • New classification of large bowel diverticulitis • Understanding the pathophysiology, diagnostics and management of lower GI bleeding • Assessing and improving emotional intelligence in surgeons and surgical trainees • Muscle map (convolutional neural network) of the pelvic floor • Obstetric anal sphincter injury • Novel therapies and investigations in anorectal disorders
PUBLICATIONS
2022
Sarofim et al. 2022 “A new hernia: Meckel's diverticulum within a parastomal hernia.” J Surg Case Rep 2022: rjac398 PMID:36324763 Surgical Staff: Shahrir Kabir Sang et al. 2022 “Lipid-polymer nanocarrier platform enables X-ray induced photodynamic therapy against human colorectal cancer cells.” Biomed Pharmacother 155: 113837 PMID:36271586 Surgical Staff: Alexander Engel Li et al. 2022 “Deep Sequencing of Early T Stage Colorectal Cancers Reveals Disruption of Homologous Recombination Repair in Microsatellite Stable Tumours with High Mutational Burdens.” Cancers (Basel) 14: 2933 PMID:35740599 Surgical Staff: Alexander Engel Steinberg et al. 2022 “Lynch syndrome testing of colorectal cancer patients in a high-income country with universal healthcare: a retrospective study of current practice and gaps in seven australian hospitals.” Hered Cancer Clin Pract 20: 18 PMID:35509103 Surgical Staff: Alexander Engel Gugusheff et al. 2022 “Population-level utilisation of neoadjuvant radiotherapy for the treatment of rectal cancer.” J Surg Oncol 126: 322-329 PMID:35362557 Surgical Staff: Alexander Engel Toh et al. 2022 “Attitudes towards Enhanced Recovery after Surgery (ERAS) interventions in colorectal surgery: nationwide survey of Australia and New Zealand colorectal surgeons.” Langenbecks Arch Surg 407: 1637-1646 PMID:35275247 Surgical Staff: Alexander Engel Trieu et al. 2022 “Flatus Incontinence and Fecal Incontinence: A Case-Control Study.” Diseases of the Colon & Rectum 66 : 591-597 Surgical Staff: Margaret Schnitzler Malhi et al. 2022 “Tagging psychopathy by being more analytical.” Bipolar Disorders 25: 162-163 Surgical Staff: Margaret Schnitzler Hoek et.al. 2022 “Laparoscopic peritoneal lavage versus sigmoidectomy for perforated diverticulitis with purulent peritonitis: three-year follow-up of the randomised LOLA trial.” Surgical Endoscopy 36: 7764-7774 Surgical Staff: Alexander Engel Gawria et al. 2022 “Classification of intraoperative adverse events in visceral surgery.” Surgery 171 :1570-1579 Surgical Staff: Alexander Engel Chan DL et al. 2022 “Computed tomography (CT)-defined sarcopenia and myosteatosis are prevalent in patients with neuroendocrine neoplasms (NENs) treated with peptide receptor radionuclide therapy (PRRT).” European Journal of Clinical Nutrition 76: 143-149 Surgical Staff: Alexander Engel
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2021
Lyu et al. 2021 “Highly specific detection of KRAS single nucleotide polymorphism by asymmetric PCR/SERS assay.” Analyst 146: 5714-5721 PMID:34515700 Surgical Staff: Alexander Engel Tse et al. 2021 “Genomic, Microbial and Immunological Microenvironment of Colorectal Polyps.” Cancers (Basel) 13: 3382 PMID:34298598 Surgical Staff: Alexander Engel Sang et al. 2021 “Liposome technologies towards colorectal cancer therapeutics.” Acta Biomater 127: 24-40 PMID:33812076 Surgical Staff: Alexander Engel Chan et al. 2021 “Correction: Serum bicarbonate is a marker of peri-operative mortality but is not associated with long term survival in colorectal cancer.” PLoS One 15 (8) PMID: 34351923 Surgical Staff: Alexander Engel Toh et al. 2021 “Bowel Preparation and Oral Antibiotic Agents for Selective Decontamination in Colorectal Surgery: Current Practice, Perspectives, and Trends in Australia and New Zealand, 2019-2020.” Surg Infect (Larchmt) 22: 836-844 PMID:33761307 Surgical Staff: Alexander Engel Steffen et al. 2021 “Molecular Features of Lymph Node Metastasis in T1/2 Colorectal Cancer from Formalin-Fixed Paraffin-Embedded Archival Specimens.” J Proteome Res 20: 1304-1312 PMID:33427478 Surgical Staff: Alexander Engel
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ENDOCRINE Head of Department: Stanley Sidhu
RESEARCH SUPERVISION (2021-2022)
Anthony Glover • University of Sydney Supervision of Higher degree research course completed • Master of Surgery Program Lead • 4 MD Students • 1 MPH Student • 1 BA Student Stanley Sidhu • 2 MD Students • 3 PhD Students Mark Sywak • 2 Master of Surgery Students • 1 MD Student
DEPARTMENTAL RESEARCH RESOURCES
CLINICAL DATABASES TO SUPPORT OUTCOMES RESEARCH • Adrenal Surgery Database • Thyroid/Parathyroid Surgery Database • Thyroid Cancer • Follow up Database • Australian and New Zealand Thyroid Cancer Registry (ANZTCR) LINKS TO TRANSLATIONAL RESEARCH PARTNERS OR UNIVERSITY DEPARTMENTS
Garvan Institute (Genomics) Kolling Institute Cancer Genetics Sydney University Discipline of Surgery
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• School of Biomedical Engineering, University of Technology • EnGeneIC Pty Ltd
CURRENT RESEARCH ACTIVITY
• Targeted nanoparticle therapy in medullary thyroid cancer and poorly differentiated thyroid cancer • Noncoding RNAs as diagnostic and therapeutic targets in adrenocortical cancer and neuroendocrine cancers • A novel covid vaccine for healthy volunteers and immunocompromised cancer patients – a comparative trial • Measurable outcomes in endocrine surgery to enhance global care • Garvan and University of Sydney Endocrine Cancer Program (ECP) – integrating endocrine patient care with genomic analysis
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• Comparisons of endocrine tumour recurrence • Studies of the influences of the long non-coding RNAs and micro-RNAs in cancer and cancer therapies • Study of thyroid cancer patients with distant metastasis (cohort study) • Alternative splicing and RBM10 mutations in advanced thyroid cancer (cohort study) • Prospective study of radio-frequency ablation for the management of benign thyroid nodular disease • Targeted neoadjuvant therapy for locally advanced thyroid cancer • Prospective study of nerve integrity monitoring in conventional thyroidectomy
PUBLICATIONS
2022
Lawless et al. 2022 “Refractory Riedel's thyroiditis managed with low dose radiotherapy.” Rep Pract Oncol Radiother 27: 591-592 PMID:36186699 Surgical Staff: Alex Papachristos, Stanley Sidhu Perrier et al. 2022 “Surgical Aspects of Primary Hyperparathyroidism.” J Bone Miner Res 37: 2373-2390 PMID:36054175 Surgical Staff: Mark Sywak Chui et al. 2022 “Unexpected deaths after endocrine surgery: learning from rare events using a national audit of surgical mortality.” Br J Surg 109: 1164-1171 PMID:35927948 Surgical Staff: Alex Papachristos, Stanley Sidhu, Mark Sywak, Anthony Glover Papachristos et al. 2022 “Outcomes of Papillary Thyroid Microcarcinoma Presenting with Palpable Lateral Lymphadenopathy.” Thyroid 32: 1086-1093 PMID:35703333 Surgical Staff: Alex Papachristos, Mark Sywak, Stanley Sidhu, Anthony Glover Papachristos et al. 2022 “Thyroidectomy in Australia 2022: lessons from 21,000 consecutive cases.” ANZ J Surg 92: 1626-1630 PMID:35689169 Surgical Staff: Alex Papachristos, Anthony Glover, Mark Sywak, Stanley Sidhu Wijewardene et al. 2022 “A Retrospective Cohort Study with Validation of Predictors of Differentiated Thyroid Cancer Outcomes.” Thyroid 32: 1201-1210 PMID:35620896 Surgical Staff: Anthony Glover, Mark Sywak, Stanley Sidhu Thwin et al. 2022 “Applying the 'three buckets' theory of situational awareness to surgical training: an updated framework.” ANZ J Surg 92: 1498-1501 PMID:35488464 Surgical Staff: Anthony Glover Wei et al. 2022 “Factors That Inform Individual Decision Making Between Active Surveillance, Hemithyroidectomy and Total Thyroidectomy for Low-Risk Thyroid Cancer: A Scoping Review.” Thyroid 32: 807-818 PMID:35438545 Surgical Staff: Anthony Glover Jonker et al. 2022 “Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection.” Eur J Nucl Med Mol Imaging 49: 3557-3570 PMID:35389070 Surgical Staff: Mark Sywak Leong et al. 2022 “ The prognostic Impact of Extent of Vascular Invasion in Follicular Thyroid Carcinoma.” World J Surg doi: 10.1007/s00268-022-06696-6 Surgical Staff: Anthony Glover, Mark Sywak, Stan Sidhu Papachristos et al. 2022 “ASO Author Reflections: Medullary Thyroid Cancer-Establishing Treatment Paradigms in a Rapidly Evolving Therapeutic Landscape.” Ann Surg Oncol 29: 72-73 PMID:34739638 Surgical Staff: Alex Papachristos, Anthony Glover, Stanley Sidhu Xu et al. 2022 “International Medullary Thyroid Carcinoma Grading System: A Validated Grading System for Medullary Thyroid Carcinoma.” J Clin Oncol 40: 96-104 PMID:34731032 Surgical Staff: Anthony Glover, Alex Papachristos Vikneson et al. 2022 “Tumour volume is a predictor of lymphovascular invasion in differentiated small thyroid cancer.” Endocr Oncol 2: 42-49 PMID: 37435463 Surgical Staff: Alex Papachristos, Mark Sywak , Anthony Glover, Ahmad Aniss Kesby et al. 2022 “Outcomes of Advanced Medullary Thyroid Carcinoma in the Era of Targeted Therapy.” Ann Surg Oncol 29: 64-71 PMID:34716515 Surgical Staff: Alex Papachristos, Mark Sywak, Stanley Sidhu, Anthony Glover Sidhu et al. 2022 “Long-Term Cure of Primary Hyperparathyroidism After Scan-Directed Parathyroidectomy: Outcomes from a UK Endocrine Surgery Unit.” World J Surg 46: 2195-2196 PMID:35672587 Surgical Staff: Stanley Sidhu Wang et al. 2022 “Genotype–Phenotype Correlations and Clinical Outcomes in 155 Cases of Pheochromocytoma and Paraganglioma.” World Journal of Surgery 1-9 Surgical Staff: Alex Papachristos, Anthony Glover, Mark Sywak, Stan Sidhu, Ahmad Aniss
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Vikneson et al. 2022 “Tumour volume is a predictor of lymphovascular invasion in small, differentiated thyroid microcarcinoma.” Endocrine Oncology 1(aop) Surgical Staff: Alex Papachristos, Anthony Glover, Mark Sywak, Ahmad Aniss
2021
Wijewardene et al. 2021 “Change in Practice of Radioactive Iodine Administration in Differentiated Thyroid Cancer: A Single-Centre Experience.” Eur Thyroid J 10: 408-415 PMID:34540711 Surgical Staff: Anthony Glover, Mark Sywak, Stanley Sidhu Parkin et al. 2021 “What is the Accuracy of the ACS-NSQIP Surgical Risk Calculator in Emergency Abdominal Surgery? A Meta-Analysis.” J Surg Res 268: 300-307 PMID:34392184 Surgical Staff: Anthony Glover Nickel et al. 2021 “Thyroid cancer clinicians' views and experiences of delayed treatment during the COVID-19 pandemic: An international cross-sectional survey.” ANZ J Surg 91: 2562-2564 PMID:34350698 Surgical Staff: Anthony Glover Jonker et al. 2021 “Correction to: Multimodality Treatment Improves Locoregional Control, Progression-Free and Overall Survival in Patients with Anaplastic Thyroid Cancer: A Retrospective Cohort Study Comparing Oncological Outcomes and Morbidity between Multimodality Treatme” Ann Surg Oncol 28: 891 PMID:34279756 Surgical Staff: Anthony Glover, Stanley Sidhu, Mark Sywak Tao et al. 2021 “BRAF V600E Status Sharply Differentiates Lymph Node Metastasis-associated Mortality Risk in Papillary Thyroid Cancer.” J Clin Endocrinol Metab 106: 3228-3238 PMID:34273152 Surgical Staff: Mark Sywak Di Marco et al. 2021 “Focused parathyroidectomy without intraoperative parathyroid hormone measurement in primary hyperparathyroidism: Still a valid approach?” Surgery 170: 1383-1388 PMID:34144815 Surgical Staff: Anthony Glover, Alex Papachristos, Mark Sywak, Stanley Sidhu Jonker et al. 2021 “ASO Author Reflections: Multimodality Treatment in Anaplastic Thyroid Cancer: Improving Survival Outcomes and Balancing Treatment Related Complications.” Ann Surg Oncol 28: 7531-7532 PMID:34131820 Surgical Staff: Mark Sywak Jonker et al. 2021 “Multimodality Treatment Improves Locoregional Control, Progression-Free and Overall Survival in Patients with Anaplastic Thyroid Cancer: A Retrospective Cohort Study Comparing Oncological Outcomes and Morbidity between Multimodality Treatment and Limited” Ann Surg Oncol 28: 7520-7530 PMID:34032961 Surgical Staff: Anthony Glover, Stanley Sidhu, Mark Sywak Ndegwa et al. 2021 “Intraoperative ultrasound facilitates localization in a morbidly obese patient undergoing posterior retroperitoneoscopic adrenalectomy.” ANZ J Surg 91: 2215-2217 PMID:33788348 Surgical Staff: Mark Sywak Joseph et al. 2021 “An unusual case of a penetrating neck injury (PNI) illustrating the use of a "no zone" approach for the management of this injury and a review of the literature.” Trauma Case Rep 32: 100402 PMID:33644288 Surgical Staff: Anthony Glover, Walid Mohabbat Jaffar et al. 2021 “Predicting distant metastatic disease in differentiated thyroid cancer: a matched case-control study.” ANZ J Surg 91: 716-723 PMID:33590959 Surgical Staff: Anthony Glover, Stanley Sidhu, Mark Sywak Papachristos et al. 2021 “Correction to: Bi-national Review of Phaeochromocytoma Care: Is ICU Admission Always Necessary?” World J Surg 45: 1252-1253 PMID:33523254 Surgical Staff: Alex Papachristos, Stanley Sidhu, Mark Sywak Papachristos et al. 2021 “Pros and cons of hemi-thyroidectomy for low-risk differentiated thyroid cancer.” ANZ J Surg 91: 1704-1710 PMID:33438352 Surgical Staff: Alex Papachristos, Anthony Glover, Mark Sywak, Stanley Sidhu Papachristos et al. 2021 “Bi-national Review of Phaeochromocytoma Care: Is ICU Admission Always Necessary?” World J Surg 45: 790-796 PMID:33219416 Surgical Staff: Alex Papachristos, Stanley Sidhu, Mark Sywak Nickel et al. 2021 “Delays to Low-risk Thyroid Cancer Treatment During COVID-19-Refocusing From What Has Been Lost to What May Be Learned and Gained.” JAMA Otolaryngol Head Neck Surg 147: 5-6 PMID:33119084 Surgical Staff: Anthony Glover van der Plas et al. 2021 “Parathyroidectomy for patients with secondary hyperparathyroidism in a changing landscape for the management of end-stage renal disease.” Surgery 169: 275-281 PMID:33059930 Surgical Staff: Stanley Sidhu, Mark Sywak Nylén et al. 2021 “Prophylactic central lymph node dissection informs the decision of radioactive iodine ablation in papillary thyroid cancer.” Am J Surg 221: 886-892 PMID:32878695 Surgical Staff: Mark Sywak, Anthony Glover, Stanley Sidhu Papachristos et al. 2021 “Thyroidectomy technique: Defusing the recurrent laryngeal nerve - The superior approach.” Am J Surg 222: 712-714 PMID:33775410 Surgical Staff: Stanley Sidhu, Alex Papachristos
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HAND AND PERIPHERAL NERVE SURGERY Head of Department: Richard Lawson
RESEARCH SUPERVISION (2021-2022)
Richard Lawson Education and Teaching Modules: • Hand Trauma Module: Essentials In Clinical Trauma Care Brahman Sivakumar • 4 MD Students Projects include retrospective cohort study comparing metacarpal and phalangeal intramedullary screw fixation; arthroscopic carpal fusion targeted muscle reinnervation David Stewart • Co-Supervisor, Master of Surgery Student – volar plate repair in open dislocation
DEPARTMENTAL RESEARCH RESOURCES
CLINICAL DATABASES TO SUPPORT OUTCOMES RESEARCH • Hand and Peripheral Nerve Surgery Database • Tetraplegia Database
CURRENT NSLHD HUMAN RESEARCH ETHICS APPLICATION (HREA) APPROVALS • Ultrasound to Predict Tendinopathy from Distal Radius Volar Locking Plates: A Pilot Study
LINKS TO TRANSLATIONAL RESEARCH PARTNERS OR UNIVERSITY DEPARTMENTS
Macquarie University
•
CURRENT RESEARCH ACTIVITY
• Systematic reviews and meta-analyses on distal interphalangeal joint arthroplasty; early vs. late replantation; rib grafts vs proximal scaphoid • Registry analysis – trends in outcomes in wrist arthroplasty in Australia • Arthroscopic bone graft for scaphoid • Arthroscopic lunate excision for Kienböck’s disease • Outcomes of plate removal – patient satisfaction • Review of Scheker distal radial ulnar joint arthroplasties • K wire treatment of mallet injuries • Radial collateral ligament injuries of thumb metacarpophalangeal joint • Flexor tendon adhesions to phalangeal fractures • Intra-medullary screw damage to phalangeal head cartilage – assessment of defect size
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PUBLICATIONS
2022
Sivakumar et al. 2022 “The Utility of the Interosseous Arterial System for Microvascular Interposition Grafting.” J Hand Surg Asian Pac Vol 27: 1067-1070 PMID:36606357 Surgical Staff: Brahman Sivakumar, Richard Lawson Tiedgen et al. 2022 “The Volar Midline Longitudinal Groove of the Middle Phalanx: An Anatomic Study and Clinical Implications.” J Hand Surg Am PMID:36372597 Surgical Staff: Richard Lawson, Brahman Sivakumar Castillo et al. 2022 “The Efficacy of Antegrade Homodigital Neurovascular Island Flaps in Distal Fingertip Reconstruction: A Systematic Literature Review.” Hand (N Y) 15589447221127332 PMID:36278422 Surgical Staff: Richard Lawson, Brahman Sivakumar Ho et al. 2022 “An unusual growth in the nail matrix: A case of superficial acral fibromyxoma.” Skin Health Dis 2: e121 PMID:36092267 Surgical Staff: David Stewart Bhardwaj et al. 2022 “Anatomic Variations of the Musculocutaneous Nerve and Clinical Implications for Restoration of Elbow Flexion.” J Hand Surg Am 47: 970-978 PMID:36064510 Surgical Staff: Brahman Sivakumar Tolerton et al. 2022 “Recurrent Trigger Finger Caused by Herniation of Flexor Digitorum Profundus through the Chiasma - A Case Report.” J Hand Surg Asian Pac Vol 27: 732-735 PMID:35965358 Surgical Staff: Brahman Sivakumar, Richard Lawson Thatcher et al. 2022 “Simultaneous Reconstruction of the Distal Radioulnar Joint Ligaments and Interosseous Membrane Combined with Ulna Shortening Osteotomy for Chronic Essex-Lopresti Injury.” J Hand Surg Asian Pac Vol 27: 574-579 PMID:35808872 Surgical Staff: Brahman Sivakumar Sivakumar et al. 2022 “Temporal trends in the management of metacarpal and phalangeal fractures in the 21st century: an analysis of Australian population-based data.” ANZ J Surg 92: 2655-2660 PMID:35785509 Surgical Staff: Brahman Sivakumar, Michael Symes, Richard Lawson Multani et al. 2022 “The One-Bone Forearm: A Review.” Hand (N Y) 15589447221084010 PMID:35321571 Surgical Staff: Richard Lawson, Brahman Sivakumar Koong et al. 2022 “Open versus Single- or Dual-Portal Endoscopic Carpal Tunnel Release: A Meta-Analysis of Randomized Controlled Trials.” Hand (N Y) 15589447221075665 PMID:35179060 Surgical Staff: Richard Lawson, Brahman Sivakumar Shihab et al. 2022 “Outcomes of Arthroscopic-Assisted Distal Radius Fracture Volar Plating: A Meta-Analysis.” J Hand Surg Am 47: 330-340.e1 PMID:35168831 Surgical Staff: Brahman Sivakumar Zhou et al. 2022 “Free Medial Femoral Condyle Flap for Reconstruction of Scaphoid Nonunion: A Systematic Review.” J Reconstr Microsurg 38: 593-603 PMID:34905783 Surgical Staff: David Stewart, Richard Lawson, Brahman Sivakumar Zhou et al. 2022 “Toe-to-Finger Vascularized Joint Transfers for Proximal Interphalangeal Joint Reconstruction: A Systematic Review.” Hand (N Y) 17: 1031-1038 PMID:33511878 Surgical Staff: Richard Lawson, Brahman Sivakumar Sivakumar et al. 2022 “Intramedullary Compression Screw Fixation of Proximal Phalangeal Fractures: A Systematic Literature Review.” Hand (N Y) 17: 595-601 PMID:32988227 Surgical Staff: Brahman Sivakumar, James Ledgard, Richard Lawson Sivakumar et al. 2022 “Sagittal Band Injuries: A Review and Modification of the Classification System.” J Hand Surg Am 47: 69-77 PMID:34756751 Surgical Staff: Brahman Sivakumar, Mark Hile, Richard Lawson Ziaziaris et al. 2022 “The Anatomy of Nerve Transfers Used in Tetraplegic Hand Reconstruction.” J Hand Surg Am 47: 1121.e1-1121.e6 PMID:34702629 Surgical Staff: James Ledgard Sivakumar et al. 2022 “Biomechanical Analysis of Abductor Pollicis Longus Lasso Suspensionplasty for Trapeziectomy.” J Hand Surg Am 47: 581.e1-581.e9 PMID:34330561 Surgical Staff: Brahman Sivakumar, Richard Lawson Rothe et al. 2022 “Metal-on-metal disease in high-motion wrist arthroplasty.” Hand (NY) 17: NP11 – NP16 Surgical staff: Brahman Sivakumar Probert et al. 2022 “The impact of COVID-19 on spinal cord injuries and trauma at a tertiary referral centre in Sydney.” J Spine Surg 8: 418-425. Surgical staff : Brahman Sivakumar , Michael Symes (orthopaedics), Randolph Gray (orthopaedics) Xu et al. 2022 “ Basic statistics for surgeons.” J Hand Surg Asian Pac 27: 421-429 Surgical staff: Brahman Sivakumar Youlden et al. 2022 “Things are not always what they seem. A case of gastric adenocarcinoma to the toe.” ANZ J Surg 91: 267 – 269 Surgical staff: Brahman Sivakumar, Michael Symes (orthopaedics) Graham DJ et al. 2022 . Triangular vascularized free fibular flap for massive carpal reconstruction. J Hand Surg Am 47 : 196.e1 – 196.e6 Surgical staff: Brahman Sivakumar
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