RNSH Surgery & Anaesthesia Research Activity Report 21-22

CURRENT RESEARCH ACTIVITY

• Outcome of primary repair of obstetric sphincter rupture • Classification of intra-operative complications • Nanotechnology and improvement in diagnosis and management of CRC lymph node metastasis • Photodynamic therapy in combination with low dose radiotherapy as an alternative to chemoradiation in advanced and recurrent rectal cancer • Integrative molecular classification of colorectal polyps • Molecular signature of lymph node metastasis in early colorectal cancer • New classification of large bowel diverticulitis • Understanding the pathophysiology, diagnostics and management of lower GI bleeding • Assessing and improving emotional intelligence in surgeons and surgical trainees • Muscle map (convolutional neural network) of the pelvic floor • Obstetric anal sphincter injury • Novel therapies and investigations in anorectal disorders

PUBLICATIONS

2022

Sarofim et al. 2022 “A new hernia: Meckel's diverticulum within a parastomal hernia.” J Surg Case Rep 2022: rjac398 PMID:36324763 Surgical Staff: Shahrir Kabir Sang et al. 2022 “Lipid-polymer nanocarrier platform enables X-ray induced photodynamic therapy against human colorectal cancer cells.” Biomed Pharmacother 155: 113837 PMID:36271586 Surgical Staff: Alexander Engel Li et al. 2022 “Deep Sequencing of Early T Stage Colorectal Cancers Reveals Disruption of Homologous Recombination Repair in Microsatellite Stable Tumours with High Mutational Burdens.” Cancers (Basel) 14: 2933 PMID:35740599 Surgical Staff: Alexander Engel Steinberg et al. 2022 “Lynch syndrome testing of colorectal cancer patients in a high-income country with universal healthcare: a retrospective study of current practice and gaps in seven australian hospitals.” Hered Cancer Clin Pract 20: 18 PMID:35509103 Surgical Staff: Alexander Engel Gugusheff et al. 2022 “Population-level utilisation of neoadjuvant radiotherapy for the treatment of rectal cancer.” J Surg Oncol 126: 322-329 PMID:35362557 Surgical Staff: Alexander Engel Toh et al. 2022 “Attitudes towards Enhanced Recovery after Surgery (ERAS) interventions in colorectal surgery: nationwide survey of Australia and New Zealand colorectal surgeons.” Langenbecks Arch Surg 407: 1637-1646 PMID:35275247 Surgical Staff: Alexander Engel Trieu et al. 2022 “Flatus Incontinence and Fecal Incontinence: A Case-Control Study.” Diseases of the Colon & Rectum 66 : 591-597 Surgical Staff: Margaret Schnitzler Malhi et al. 2022 “Tagging psychopathy by being more analytical.” Bipolar Disorders 25: 162-163 Surgical Staff: Margaret Schnitzler Hoek et.al. 2022 “Laparoscopic peritoneal lavage versus sigmoidectomy for perforated diverticulitis with purulent peritonitis: three-year follow-up of the randomised LOLA trial.” Surgical Endoscopy 36: 7764-7774 Surgical Staff: Alexander Engel Gawria et al. 2022 “Classification of intraoperative adverse events in visceral surgery.” Surgery 171 :1570-1579 Surgical Staff: Alexander Engel Chan DL et al. 2022 “Computed tomography (CT)-defined sarcopenia and myosteatosis are prevalent in patients with neuroendocrine neoplasms (NENs) treated with peptide receptor radionuclide therapy (PRRT).” European Journal of Clinical Nutrition 76: 143-149 Surgical Staff: Alexander Engel

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