RNSH Surgery & Anaesthesia Research Activity Report 21-22

LINKS TO TRANSLATIONAL RESEARCH PARTNERS OR UNIVERSITY DEPARTMENTS

• The George Institute for Global Health, UNSW Sydney • The Kirby Institute, UNSW Sydney • Australian and New Zealand Intensive Care Research Centre • National Health and Medical Research grant review panels • Brain and Mind Centre, University of Sydney • Department of Psychology, Macquarie University • Australian and New Zealand Centre for Outcome and Resource Evaluation • ANZICS CTG Intensive Care Research Coordinator Interest Group (IRCIG) • Asia Pacific Sepsis Alliance • Sepsis Australia • International Sepsis Forum • Australian College of Critical Care Nurses – NSW Committee and Research Advisory Panel • European Society of Intensive Care Medicine • Society of Critical Care Medicine • Stroke Foundation • Brain Injury Australia

CURRENT RESEARCH ACTIVITY

• REMAP CAP: Adaptive platform trial for community acquired pneumonia • ECMO CARD: Extra Corporeal Membrane Oxygenation for 2019 novel Coronavirus Acute Respiratory Disease • EXCEL: A collaborative bi-national registry on the treatment and outcomes of patients requiring ECMO in ICU • SAHaRA: Aneurysmal Subarachnoid Haemorrhage-Red Blood Cell Transfusion and Outcome • SPRINT-SARI: Short Period Incidence study of Severe Acute Respiratory Infection • TTM2 HEA: Targeted Hypothermia versus Targeted Normothermia after Out-of-hospital Cardiac Arrest - Health Economic Evaluation sub-study • Point Prevalence Program (PPP): PPP is a unique collaborative program of coordinated observational research across Australian and New Zealand adult and paediatric intensive care units • REVISE: The re-evaluating the inhibition of stress erosions trial • FluDReSS: Fludrocortisone Dose Response Relationships & Vascular Responsiveness in Septic Shock • ARISE Fluid: The Australasian Resuscitation in Sepsis Evaluation: Fluid or Vasopressors in Emergency Department • Sepsis in AKI: ARISE Fluid sub-study- Sepsis in Acute Kidney Injury • BONE ZONE: Bone Loss Prevention with Zoledronic Acid or Denosumab in Critically Ill Women • Immune CAP: Tissue Resident Memory Cells in Severe Community Acquired Pneumonia • NEURO K: Establishing a blood test for detecting the extent of neurological damage using brain derived cell free DNA • MEGA ROX: The Mega Randomised Registry Trial Comparing Conservative vs. Liberal Oxygenation Targets • EPO TRAUMA: A randomised, double-blind, placebo-controlled trial of erythropoietin alfa versus placebo in mechanically ventilated critically ill patients following traumatic injury • EVIDENCE: Efficacy and value in expedited out of hospital arrest care with end tidal CO2 (ETCO2) ECMO CPR (ECPR) • AMOSCI: Acute Management of Spinal Cord Injury • Sepsis ICD Coding Validation Study: Validation of ICD coding methods in estimating sepsis epidemiology • NOTACS: Effect of Nasal High-Flow Oxygen Therapy on Patient-Centred Outcomes in Patients at High Risk of Postoperative Pulmonary Complications After Cardiac Surgery: A Multicentre Randomised Controlled Trial • Wellbeing Survey: Wellness survey in critical care health worker • Experiences of significant others of ICU patients with severe burns

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