RNSH Surgery & Anaesthesia Research Activity Report 21-22

• IMPART–TRIAL: Clinical trial testing the Prevena surgical incision management system in renal transplant patients o Multicentre RCT involving Health Partners RPA and Westmead Hospitals o RNSH is the lead site and in-charge of the project • Comparison trials of two vascular closure devices - FemoSealTM vs StarCloseTM • Mortality study of Paclitaxel use at North Shore Hospital Campus • Study of multiple renal artery use in transplant patients • Study of duplex ultrasound in the treatment of renal transplant patients • Analysis of infra-inguinal directional atherectomy o Multi-year study assessing the HawkOne DA system in infra-inguinal occlusive disease • RANGER paclitaxel coated balloon for treatment of infra-popliteal arterial steno-occlusive disease • Endovascular Balloon Occlusion of the Aorta (EBOA) in Code Crimson Trauma • Pilot Study: The Evaluation of Endoleak after EVAR using Subtraction CT Iodine Mapping • The LIFE-BTK Randomized Controlled Trial (A pre-market evaluation of the ESPRIT BTK Everolimus Eluting Bioresorbable Scaffold System for treatment of narrowed infrapopliteal lesions in patients with arterial narrowing in infrapopliteal lesions causing Critical Limb Ischemia • o Use of HawkOne DA in common femoral artery occlusive disease o Safety and efficacy of directional atherectomy in In-Stent Restenosis Bright BIOTRONIK: First-in-Human assessment of the Safety and Clinical Performance of Sirolimus Derivative-Coated Balloon in the Treatment of Subjects with de Novo Lesions in the Superficial Femoral and Proximal Popliteal Artery • First in Man study: A Prospective, Multi-Centre, Single-Arm, Feasibility Study to Assess the Safety and Performance With the SUNDANCETM Drug Coated Balloon for the Treatment of De Novo or Restenotic Lesions in Infra-Popliteal Arteries. “SWING Study” • ALUCENT: Feasibility Study of the Restoration System (VRS) for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery (SFA) and/or Proximal Popliteal Artery (PPA) COLLABORATIVE WORKWITH CARDIOLOGY RESEARCH GROUP • Dr Paul Bonnitcha: Assessment of Carotid Atherosclerotic plaques with FMISO-PET Scans (CatPET study) • Dr Gemma Figtree: STimulating Adrenergic Receptors to improve clinical outcomes in patients with Peripheral Arterial Disease STAR-PAD trial • Dr Gemma Figtree: BioHEART: Cardiology Biobanking for Biomarker Discovery NEONATAL ICU • Neonatal ICU (Eveline Staub): Renal development in premature neonates (Vascular Ultrasound) ICU • Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis RHEUMATOLOGY • Dr R Laurent: review and refinement of clinical algorithm for diagnosis of giant cell arteritis using ultrasound RENAL • Factors associated with functional arteriovenous fistula at hemodialysis start and arteriovenous fistula non-use in a single-center cohort

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